sterol regulatory element binding transcription factor 1

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Synonym

Sterol regulatory element-binding protein 1, SREBF1, SREBP1, SREBP-1

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:328.30 cerebellum:692.70 brain stem:- corpus callosum/glia:29.20 pineal gland:- peripheral nerve:122.70 spine:112.30 retina:- eye:229.20 artery/aorta:- vein:66.60 lymphnode:10.10 peripheral blood:72.90 spleen:18.90 thymus:657.10 bone marrow:39.40 adipose:- bone:25.60 skin:81.60
GeneChip cerebrum:7.05 cerebellum:6.35 brain stem:7.03 corpus callosum/glia:7.86 pineal gland:- peripheral nerve:7.12 spine:7.20 retina:- eye:- artery/aorta:6.70 vein:6.76 lymphnode:7.09 peripheral blood:- spleen:6.21 thymus:6.82 bone marrow:6.40 adipose:7.37 bone:- skin:7.19
CAGE cerebrum:3.95 cerebellum:- brain stem:4.10 corpus callosum/glia:4.87 pineal gland:3.05 peripheral nerve:- spine:4.06 retina:- eye:- artery/aorta:3.40 vein:3.86 lymphnode:4.04 peripheral blood:- spleen:3.48 thymus:3.97 bone marrow:- adipose:3.71 bone:- skin:-
RNA-seq cerebrum:2.03 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:2.61 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:1.73 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:54.70 placenta:69.20 prostate:157.70 ovary:- testis:354.80 heart:38.30 muscle:- esophagus:- stomach:- intestine:- colon:118.70     liver/hepato:42.20        lung:151.50    bladder:125.60 kidney:52 pituitary:- thyroid/parathyroid:- adrenal gland:152.40 pancreas:142.30 breast:37.20 salivary:-
GeneChip uterus:6.71 placenta:7.07 prostate:7.20 ovary:6.49 testis:7.68 heart:6.05 muscle:6.41 esophagus:7.58 stomach:6.72 intestine:6.55 colon:6.88 liver/hepato:8.52 lung:6.61 bladder:- kidney:6.82 pituitary:7.32 thyroid/parathyroid:6.70 adrenal gland:8.84 pancreas:6.12 breast:7.97 salivary:7.67
CAGE uterus:3.61 placenta:4.10 prostate:3.68 ovary:4.42 testis:4.42 heart:3.40 muscle:3.66 esophagus:4.41 stomach:- intestine:4.68 colon:3.97     liver/hepato:5.13    lung:3.98 bladder:3.83 kidney:3.64 pituitary:3.17 thyroid/parathyroid:2.80 adrenal gland:- pancreas:2.81 breast:3.92 salivary:4.34
RNA-seq uterus:- placenta:- prostate:2.74 ovary:3.08 testis:2.35 heart:0.88 muscle:2.13 esophagus:- stomach:- intestine:- colon:1.47     liver/hepato:3.37        lung:2.50    bladder:- kidney:2.35 pituitary:- thyroid/parathyroid:3.45 adrenal gland:3.41 pancreas:- breast:2.22 salivary:-

IDs

Refseq ID NM_004176
Gene ID 6720
Unigene ID Hs.592123
Probe set ID 202308_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000072310
GTEx ID ENSG00000072310

Orthologous Gene

Mouse[1]  NM_011480
Rat[1]  NM_011480

Chromosomal Region

Gene Family (Interpro ID)

-

Link to Pubmed  (Pubmed ID)

7759101
7903453
8006035
8156598
8314806
8402897
8626610
8918891
9062340
9070916
9242699
9634703
9651391
9765204
10224053
10235267
10585876
10619424
10627507
10915800
10949029
11257259
11334418
11485982
11713202
11834832
11916923
11929849
11997338
12021179
12145339
12177166
12202038
12213084
12242332
12436350
12477932
12531699
12615929
12640139
12657626
12730330
12752570
14615581
14633850
14654692
14701856
14702039
14722127
14742839
14744869
14747281
14748724
14988272
15026365
15085196
15102555
15123650
15161980
15277400
15286454
15317819
15340088
15358760
15388640
15550381
15677507
15769984
15794649
15798184
15809359
15833942
16005884
16007182
16054087
16055439
16141315
16153721
16158080
16162944
16198472
16249184
16303770
16306078
16387548
16407292
16429400
16480961
16713569
16799563
16804073
16806233
16817902
16825193
16880739
16885156
17019602
17081983
17141191
17160088
17198935
17296605
17331464
17344645
17452746
17636037
17655842
17681345
17989724
18065496
18068676
18072016
18192539
18195716
18245227
18267114
18272927
18281474
18304434
18334917
18360697
18385733
18403372
18420801
18435918
18559965
18635549
18654640
18660489
18682402
18692268
18727921
18752865
18774944
18835813
18854425
18936756
18996102
19008011
19032865
19040658
19048273
19056350
19056482
19062325
19126544
19242521
19252981
19292868
19303849
19323650
19336475
19360318
19470430
19533843
19578796
19621387
19720801
19727213
19727227
19733654
19811452
19876004
19878569
19913121
19913854
19948975
19966780
20005944
20026048
20028734
20031551
20067991
20071336
20130133
20145241
20167577
20171215
20173757
20235787
20376806
20466882
20513236
20534441
20554776
20595232
20615871
20628086
20648548
20655124
20817729
20863500
20868688
20965718
20971080
20980003
21093473
21139048
21145868
21146170
21310851
21325464
21540177
21609284
21619898
21645898
21652712
21664250
21693764
21738487
21757781
21775116
21826653
21836065
21871872
21906983
21963094
21987572
21993218
22035958
22059152
22064655
22152380
22153697
22258239
22311022
22331133
22363740
22384276
22425645
22429355
22474125
22505724
22672904
22678801
22690709
22786746
22939624
22966071
22969152
22984430
23000965
23106379
23147115
23184344
23208501
23226416
23422505
23465592
23515281
23610160
23680128
23703028
23818099
23825667
23913732
23985808
24105476
24152445
24298052
24484994
24704425
24868893

Gene Ontology  (GO ID)

Biological Process

GO:0007568  aging
GO:0044255  cellular lipid metabolic process
GO:0009267  cellular response to starvation
GO:0008203  cholesterol metabolic process
GO:0008286  insulin receptor signaling pathway
GO:0008610  lipid biosynthetic process
GO:0006629  lipid metabolic process
GO:0030324  lung development
GO:0046676  negative regulation of insulin secretion
GO:0000122  negative regulation of transcription from RNA polymerase II promoter
GO:0045542  positive regulation of cholesterol biosynthetic process
GO:0031065  positive regulation of histone deacetylation
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0010867  positive regulation of triglyceride biosynthetic process
GO:0019217  regulation of fatty acid metabolic process
GO:0003062  regulation of heart rate by chemical signal
GO:0006357  regulation of transcription from RNA polymerase II promoter
GO:0051591  response to cAMP
GO:0042493  response to drug
GO:0070542  response to fatty acid
GO:0032094  response to food
GO:0033762  response to glucagon stimulus
GO:0009749  response to glucose stimulus
GO:0032570  response to progesterone stimulus
GO:0032526  response to retinoic acid
GO:0006351  transcription, DNA-dependent

Cellular Component

GO:0044444  cytoplasmic part
GO:0005829  cytosol
GO:0005783  endoplasmic reticulum
GO:0005789  endoplasmic reticulum membrane
GO:0012507  ER to Golgi transport vesicle membrane
GO:0000139  Golgi membrane
GO:0016021  integral to membrane
GO:0005635  nuclear envelope
GO:0005654  nucleoplasm
GO:0005634  nucleus
GO:0043234  protein complex

Molecular Function

GO:0003682  chromatin binding
GO:0003677  DNA binding
GO:0005515  protein binding
GO:0032403  protein complex binding
GO:0046983  protein dimerization activity
GO:0019901  protein kinase binding
GO:0043565  sequence-specific DNA binding
GO:0032810  sterol response element binding
GO:0003700  transcription factor activity