serum response factor (c-fos serum response element-binding transcription factor)

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Synonym

SRF, Serum response factor

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:21.30 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:224.60 retina:- eye:88.20 artery/aorta:- vein:- lymphnode:60.70 peripheral blood:54.70 spleen:37.80 thymus:38.70 bone marrow:39.40 adipose:80.70 bone:89.60 skin:43.20
GeneChip cerebrum:4.75 cerebellum:4.70 brain stem:4.68 corpus callosum/glia:4.75 pineal gland:- peripheral nerve:4.77 spine:4.63 retina:- eye:- artery/aorta:5.22 vein:5.32 lymphnode:5.08 peripheral blood:- spleen:4.85 thymus:4.70 bone marrow:5 adipose:4.94 bone:- skin:4.90
CAGE cerebrum:2.72 cerebellum:- brain stem:2.50 corpus callosum/glia:2.90 pineal gland:2.34 peripheral nerve:- spine:2.39 retina:- eye:- artery/aorta:4.07 vein:3.22 lymphnode:2.96 peripheral blood:- spleen:3.42 thymus:3.12 bone marrow:- adipose:2.88 bone:- skin:-
RNA-seq cerebrum:2.55 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:3.55 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:3.63 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:72.90 placenta:58.30 prostate:33.80 ovary:37.30 testis:8.70 heart:25.50 muscle:20.10 esophagus:- stomach:- intestine:- colon:25.40     liver/hepato:-        lung:73.30    bladder:- kidney:52 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:88.90 breast:92.90 salivary:-
GeneChip uterus:5.03 placenta:4.77 prostate:4.82 ovary:4.95 testis:4.96 heart:5.49 muscle:5.74 esophagus:5.10 stomach:5.01 intestine:5.20 colon:5.04 liver/hepato:4.86 lung:4.97 bladder:- kidney:4.80 pituitary:4.89 thyroid/parathyroid:4.82 adrenal gland:5.05 pancreas:5.03 breast:4.89 salivary:4.97
CAGE uterus:3.78 placenta:3.05 prostate:3.84 ovary:3.80 testis:2.95 heart:3.57 muscle:3.63 esophagus:3.84 stomach:- intestine:3.30 colon:3.71     liver/hepato:2.83    lung:3.00 bladder:4.10 kidney:2.80 pituitary:2.44 thyroid/parathyroid:2.89 adrenal gland:- pancreas:2.81 breast:2.34 salivary:2.85
RNA-seq uterus:- placenta:- prostate:4.63 ovary:4.61 testis:3.64 heart:3.76 muscle:3.76 esophagus:- stomach:- intestine:- colon:4.54     liver/hepato:2.21        lung:4.08    bladder:- kidney:3.23 pituitary:- thyroid/parathyroid:3.82 adrenal gland:4.17 pancreas:- breast:3.47 salivary:-

Gene Information

IDs

Refseq ID NM_003131
Gene ID 6722
Unigene ID Hs.520140
Probe set ID 202400_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000112658
GTEx ID ENSG00000112658

Orthologous Gene

Mouse[2]  NM_020493
Rat [0]  

Chromosomal Region

6p21.1  [43,139,037  -  43,149,243]

Gene Family (Interpro ID)

-

Link to Pubmed  (Pubmed ID)

1512232
1547771
1740119
2046671
2108863
3203386
7540136
7551568
7624133
7637780
7796532
7854423
8024585
8083237
8106390
8375385
8407951
8413226
8604338
8617811
8670842
8887666
9010223
9032301
9271374
9334314
9388250
9545312
9584171
9786846
10082523
10318842
10318869
10336466
10556093
10571058
10606656
10753652
10777532
10847592
10993896
11003651
11104785
11136726
11158291
11181183
11278942
11359793
11387340
11406578
11439182
11457859
11500490
11641790
11846562
11859076
11893590
12061776
12077347
12082086
12171911
12200418
12242287
12270917
12297045
12397177
12477932
12530967
12622724
12654640
12660819
12663674
12788062
12788374
12853125
12874181
14565952
15014501
15180964
15207639
15282327
15326221
15456770
15489334
15492011
15542842
15576363
15591049
15610731
15802564
15806162
15857835
15862967
16054032
16151017
16690609
17081983
17122890
17158926
17200232
17215356
17360478
17376895
17576768
17599918
17629633
17975004
18029348
18078809
18296735
18497331
18501668
18694962
18780286
19079548
19098903
19151320
19151755
19198601
19329434
19342595
19350017
19359245
19513551
19609363
19687146
19724058
19783823
19801679
19913121
19953255
20096952
20144681
20147408
20379614
20628086
20685657
20724380
20808827
20811705
21131446
21393865
21410985
21479245
21777672
21842128
21893058
21965288
21988832
21998125
22049076
22157009
22192413
22356487
22537405
23134219
23152437
23382706
23382855
23454662
23469924
23576568
24088304
24249383

Gene Ontology  (GO ID)

Biological Process

GO:0060055  angiogenesis involved in wound healing
GO:0008306  associative learning
GO:0055003  cardiac myofibril assembly
GO:0060947  cardiac vascular smooth muscle cell differentiation
GO:0002042  cell migration involved in sprouting angiogenesis
GO:0007160  cell-matrix adhesion
GO:0030038  contractile actin filament bundle formation
GO:0048589  developmental growth
GO:0090136  epithelial cell adhesion
GO:0010669  epithelial structure maintenance
GO:0048821  erythrocyte development
GO:0007507  heart development
GO:0001947  heart looping
GO:0060347  heart trabecula formation
GO:0060218  hemopoietic stem cell differentiation
GO:0021766  hippocampus development
GO:0060292  long term synaptic depression
GO:0001707  mesoderm formation
GO:0002011  morphogenesis of an epithelial sheet
GO:0042789  mRNA transcription from RNA polymerase II promoter
GO:0046716  muscle homeostasis
GO:0048666  neuron development
GO:0001764  neuron migration
GO:0031175  neuron projection development
GO:0001569  patterning of blood vessels
GO:0030168  platelet activation
GO:0030220  platelet formation
GO:0045597  positive regulation of cell differentiation
GO:0051491  positive regulation of filopodium assembly
GO:0045987  positive regulation of smooth muscle contraction
GO:0051091  positive regulation of transcription factor activity
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0003257  positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation
GO:0060261  positive regulation of transcription initiation from RNA polymerase II promoter
GO:0010735  positive regulation of transcription via serum response element binding
GO:0045059  positive thymic T cell selection
GO:0090009  primitive streak formation
GO:0030155  regulation of cell adhesion
GO:0051150  regulation of smooth muscle cell differentiation
GO:0033561  regulation of water loss via skin
GO:0034097  response to cytokine stimulus
GO:0009725  response to hormone stimulus
GO:0001666  response to hypoxia
GO:0009636  response to toxin
GO:0045214  sarcomere organization
GO:0043589  skin morphogenesis
GO:0043149  stress fiber formation
GO:0022028  tangential migration from the subventricular zone to the olfactory bulb
GO:0070830  tight junction assembly
GO:0006366  transcription from RNA polymerase II promoter
GO:0001829  trophectodermal cell differentiation

Cellular Component

GO:0005737  cytoplasm
GO:0000790  nuclear chromatin
GO:0005634  nucleus

Molecular Function

GO:0031490  chromatin DNA binding
GO:0005515  protein binding
GO:0042803  protein homodimerization activity
GO:0003705  RNA polymerase II transcription factor activity, enhancer binding
GO:0010736  serum response element binding
GO:0003700  transcription factor activity
GO:0008134  transcription factor binding