signal recognition particle 54kDa

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Synonym

signal recognition particle 54kDa, Signal recognition particle 54 kDa protein, signal recognition particle 54kD, SRP54

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:113.80 cerebellum:63 brain stem:- corpus callosum/glia:175 pineal gland:- peripheral nerve:- spine:336.90 retina:- eye:94 artery/aorta:179.90 vein:- lymphnode:80.90 peripheral blood:200.40 spleen:75.60 thymus:90.20 bone marrow:78.70 adipose:80.70 bone:281.50 skin:105.60
GeneChip cerebrum:6.39 cerebellum:6.51 brain stem:6.56 corpus callosum/glia:6.90 pineal gland:- peripheral nerve:6.68 spine:6.68 retina:- eye:- artery/aorta:6.60 vein:6.37 lymphnode:7.06 peripheral blood:- spleen:6.79 thymus:7.43 bone marrow:6.91 adipose:6.59 bone:- skin:6.59
CAGE cerebrum:3.85 cerebellum:- brain stem:4.12 corpus callosum/glia:3.98 pineal gland:4.24 peripheral nerve:- spine:3.97 retina:- eye:- artery/aorta:3.92 vein:3.58 lymphnode:4.00 peripheral blood:- spleen:3.95 thymus:4.11 bone marrow:- adipose:3.76 bone:- skin:-
RNA-seq cerebrum:1.79 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0.43 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:1.59 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:127.60 placenta:105.60 prostate:123.90 ovary:- testis:168.70 heart:166 muscle:40.20 esophagus:342.80 stomach:106.20 intestine:388.80 colon:42.40     liver/hepato:63.30        lung:141.70    bladder:879.30 kidney:187.10 pituitary:116 thyroid/parathyroid:- adrenal gland:50.80 pancreas:115.60 breast:297.40 salivary:-
GeneChip uterus:7.14 placenta:7.20 prostate:7.57 ovary:6.97 testis:7.58 heart:6.46 muscle:6.91 esophagus:6.91 stomach:6.87 intestine:6.98 colon:5.83 liver/hepato:7.22 lung:7 bladder:- kidney:6.36 pituitary:7.31 thyroid/parathyroid:6.93 adrenal gland:6.59 pancreas:7.30 breast:6.84 salivary:7.90
CAGE uterus:4.00 placenta:4.02 prostate:3.71 ovary:3.87 testis:4.23 heart:3.67 muscle:3.73 esophagus:3.81 stomach:- intestine:3.98 colon:3.46     liver/hepato:4.83    lung:3.84 bladder:4.00 kidney:4.30 pituitary:4.62 thyroid/parathyroid:3.85 adrenal gland:- pancreas:4.49 breast:3.67 salivary:4.79
RNA-seq uterus:- placenta:- prostate:0.00 ovary:0.91 testis:0.00 heart:0.00 muscle:0.70 esophagus:- stomach:- intestine:- colon:1.71     liver/hepato:1.34        lung:0.62    bladder:- kidney:1.25 pituitary:- thyroid/parathyroid:0.00 adrenal gland:0.98 pancreas:- breast:0.00 salivary:-

Gene Information

IDs

Refseq ID NM_001146282
Gene ID 6729
Unigene ID Hs.167535
Probe set ID 203605_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000100883
GTEx ID ENSG00000100883

Orthologous Gene

Mouse[9]  NM_011899, NM_001100110, NM_001100109
Rat[1]  NM_053871, NM_001100110, NM_001100109

Chromosomal Region

14q13.2  [35,451,163  -  35,498,773]

Gene Family (Interpro ID)

IPR003593  ATPase, AAA+ type, core
IPR000897  Signal recognition particle, SRP54 subunit, GTPase

Link to Pubmed  (Pubmed ID)

8247130
8622769
8722571
9016569
9511762
9512475
10497032
10618370
11680843
12244299
12477932
14729963
15489334
16344560
17558393
18029348
18089836
20379614
20516149
21139048
21890473
21906983
22174317
22505724
22939629
23000965
23221635
23667531
24250222
24778252
24816145

Gene Ontology  (GO ID)

Biological Process

GO:0044267  cellular protein metabolic process
GO:0010467  gene expression
GO:0006184  GTP catabolic process
GO:0045047  protein targeting to ER
GO:0042493  response to drug
GO:0006614  SRP-dependent cotranslational protein targeting to membrane
GO:0006617  SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition
GO:0006616  SRP-dependent cotranslational protein targeting to membrane, translocation
GO:0006412  translation

Cellular Component

GO:0005737  cytoplasm
GO:0005829  cytosol
GO:0016607  nuclear speck
GO:0005730  nucleolus
GO:0005634  nucleus
GO:0005786  signal recognition particle, endoplasmic reticulum targeting

Molecular Function

GO:0008312  7S RNA binding
GO:0008144  drug binding
GO:0030942  endoplasmic reticulum signal peptide binding
GO:0019003  GDP binding
GO:0005525  GTP binding
GO:0003924  GTPase activity
GO:0043021  ribonucleoprotein binding