serine/threonine kinase 11

Synonym

NY-REN-19 antigen, Serine/threonine-protein kinase LKB1, Serine/threonine-protein kinase 11, LKB1, STK11, serine/threonine kinase 11, PJS

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:21.30

cerebellum:25.20

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:30.70

spine:-

retina:-

eye:82.30

artery/aorta:-

vein:66.60

lymphnode:60.70

peripheral blood:72.90

spleen:75.60

thymus:25.80

bone marrow:39.40

adipose:-

bone:12.80

skin:28.80

GeneChip

cerebrum:6.93

cerebellum:7.26

brain stem:6.71

corpus callosum/glia:6.90

pineal gland:-

peripheral nerve:6.86

spine:6.98

retina:-

eye:-

artery/aorta:7.11

vein:7.13

lymphnode:7.21

peripheral blood:-

spleen:7.24

thymus:6.93

bone marrow:8.16

adipose:7.11

bone:-

skin:6.85

CAGE

cerebrum:2.33

cerebellum:-

brain stem:2.17

corpus callosum/glia:2.19

pineal gland:1.86

peripheral nerve:-

spine:1.91

retina:-

eye:-

artery/aorta:2.58

vein:2.35

lymphnode:2.31

peripheral blood:-

spleen:2.57

thymus:2.30

bone marrow:-

adipose:2.63

bone:-

skin:-

RNA-seq

cerebrum:2.54

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:3.60

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:3.75

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:45.60

placenta:3.60

prostate:202.80

ovary:-

testis:90.90

heart:-

muscle:-

esophagus:-

stomach:106.20

intestine:-

colon:42.40

liver/hepato:-

lung:34.20

bladder:-

kidney:145.60

pituitary:-

thyroid/parathyroid:-

adrenal gland:-

pancreas:151.10

breast:37.20

salivary:-

GeneChip

uterus:6.68

placenta:6.84

prostate:6.68

ovary:6.83

testis:8.17

heart:6.99

muscle:7.08

esophagus:7.22

stomach:7.07

intestine:7.14

colon:7.26

liver/hepato:7.14

lung:6.92

bladder:-

kidney:7.17

pituitary:7.14

thyroid/parathyroid:7.26

adrenal gland:7.42

pancreas:7.04

breast:6.94

salivary:7.12

CAGE

uterus:2.35

placenta:2.42

prostate:2.58

ovary:2.43

testis:3.92

heart:2.30

muscle:2.60

esophagus:2.72

stomach:-

intestine:2.81

colon:2.88

liver/hepato:2.90

lung:2.41

bladder:2.47

kidney:2.30

pituitary:2.09

thyroid/parathyroid:2.45

adrenal gland:-

pancreas:2.54

breast:2.83

salivary:2.39

RNA-seq

uterus:-

placenta:-

prostate:3.53

ovary:3.50

testis:4.78

heart:3.07

muscle:4.87

esophagus:-

stomach:-

intestine:-

colon:3.22

liver/hepato:2.54

lung:3.43

bladder:-

kidney:3.00

pituitary:-

thyroid/parathyroid:3.55

adrenal gland:3.30

pancreas:-

breast:3.50

salivary:-

IDs

Refseq ID	NM_000455
Gene ID	6794
Unigene ID	Hs.515005
Probe set ID	41657_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000118046
GTEx ID	ENSG00000118046

Orthologous Gene

Mouse[1]	NM_011492
Rat[1]	NM_001108069

Chromosomal Region

19p13.3 [1,205,798 - 1,228,434]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

IPR000719	Protein kinase, catalytic domain
IPR011009	Protein kinase-like domain
IPR002290	Serine/threonine-protein kinase domain
IPR017442	Serine/threonine-protein kinase-like domain
IPR001245	Tyrosine-protein kinase, catalytic domain
IPR020635	Tyrosine-protein kinase, subgroup, catalytic domain

Gene Ontology (GO ID)

Biological Process

GO:0043276	anoikis
GO:0006914	autophagy
GO:0007409	axonogenesis
GO:0007050	cell cycle arrest
GO:0006112	energy reserve metabolic process
GO:0030010	establishment of cell polarity
GO:0042593	glucose homeostasis
GO:0051645	Golgi localization
GO:0008286	insulin receptor signaling pathway
GO:0030308	negative regulation of cell growth
GO:0008285	negative regulation of cell proliferation
GO:0060770	negative regulation of epithelial cell proliferation involved in prostate gland development
GO:0050772	positive regulation of axonogenesis
GO:0045722	positive regulation of gluconeogenesis
GO:0045860	positive regulation of protein kinase activity
GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway
GO:0046777	protein amino acid autophosphorylation
GO:0006468	protein amino acid phosphorylation
GO:0051291	protein heterooligomerization
GO:0001558	regulation of cell growth
GO:0042304	regulation of fatty acid biosynthetic process
GO:0051896	regulation of protein kinase B signaling cascade
GO:0030111	regulation of Wnt receptor signaling pathway
GO:0006974	response to DNA damage stimulus
GO:0033762	response to glucagon stimulus
GO:0010212	response to ionizing radiation
GO:0033993	response to lipid
GO:0007286	spermatid development
GO:0001894	tissue homeostasis
GO:0001944	vasculature development
GO:0060070	Wnt receptor signaling pathway through beta-catenin

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0016020	membrane
GO:0005739	mitochondrion
GO:0005634	nucleus
GO:0043234	protein complex

Molecular Function

GO:0005524	ATP binding
GO:0042802	identical protein binding
GO:0030275	LRR domain binding
GO:0000287	magnesium ion binding
GO:0002039	p53 binding
GO:0005515	protein binding
GO:0032403	protein complex binding
GO:0030295	protein kinase activator activity
GO:0004674	protein serine/threonine kinase activity

serine/threonine kinase 11

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function