serine/threonine kinase 11

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Synonym

NY-REN-19 antigen, Serine/threonine-protein kinase LKB1, Serine/threonine-protein kinase 11, LKB1, STK11, serine/threonine kinase 11, PJS

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:21.30 cerebellum:25.20 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:30.70 spine:- retina:- eye:82.30 artery/aorta:- vein:66.60 lymphnode:60.70 peripheral blood:72.90 spleen:75.60 thymus:25.80 bone marrow:39.40 adipose:- bone:12.80 skin:28.80
GeneChip cerebrum:6.93 cerebellum:7.26 brain stem:6.71 corpus callosum/glia:6.90 pineal gland:- peripheral nerve:6.86 spine:6.98 retina:- eye:- artery/aorta:7.11 vein:7.13 lymphnode:7.21 peripheral blood:- spleen:7.24 thymus:6.93 bone marrow:8.16 adipose:7.11 bone:- skin:6.85
CAGE cerebrum:2.33 cerebellum:- brain stem:2.17 corpus callosum/glia:2.19 pineal gland:1.86 peripheral nerve:- spine:1.91 retina:- eye:- artery/aorta:2.58 vein:2.35 lymphnode:2.31 peripheral blood:- spleen:2.57 thymus:2.30 bone marrow:- adipose:2.63 bone:- skin:-
RNA-seq cerebrum:2.54 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:3.60 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:3.75 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:45.60 placenta:3.60 prostate:202.80 ovary:- testis:90.90 heart:- muscle:- esophagus:- stomach:106.20 intestine:- colon:42.40     liver/hepato:-        lung:34.20    bladder:- kidney:145.60 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:151.10 breast:37.20 salivary:-
GeneChip uterus:6.68 placenta:6.84 prostate:6.68 ovary:6.83 testis:8.17 heart:6.99 muscle:7.08 esophagus:7.22 stomach:7.07 intestine:7.14 colon:7.26 liver/hepato:7.14 lung:6.92 bladder:- kidney:7.17 pituitary:7.14 thyroid/parathyroid:7.26 adrenal gland:7.42 pancreas:7.04 breast:6.94 salivary:7.12
CAGE uterus:2.35 placenta:2.42 prostate:2.58 ovary:2.43 testis:3.92 heart:2.30 muscle:2.60 esophagus:2.72 stomach:- intestine:2.81 colon:2.88     liver/hepato:2.90    lung:2.41 bladder:2.47 kidney:2.30 pituitary:2.09 thyroid/parathyroid:2.45 adrenal gland:- pancreas:2.54 breast:2.83 salivary:2.39
RNA-seq uterus:- placenta:- prostate:3.53 ovary:3.50 testis:4.78 heart:3.07 muscle:4.87 esophagus:- stomach:- intestine:- colon:3.22     liver/hepato:2.54        lung:3.43    bladder:- kidney:3.00 pituitary:- thyroid/parathyroid:3.55 adrenal gland:3.30 pancreas:- breast:3.50 salivary:-

IDs

Refseq ID NM_000455
Gene ID 6794
Unigene ID Hs.515005
Probe set ID 41657_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000118046
GTEx ID ENSG00000118046

Orthologous Gene

Mouse[1]  NM_011492
Rat[1]  NM_001108069

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed  (Pubmed ID)

8889548
8988175
9425897
9428765
9537235
9760200
9837816
10208439
10362809
10408777
10508479
10642499
10642527
11297520
11430832
11445556
11668633
11733352
11741830
11853558
12097271
12218179
12234250
12477932
12489981
12533684
12552571
12595760
12753905
12805220
12847291
12879020
12912948
14511394
14511408
14517247
14517248
14668798
14676191
14702039
14976552
14985505
15077168
15121768
15183188
15188174
15231735
15287029
15292028
15331174
15485651
15489334
15561763
15607222
15608654
15617552
15731909
15733851
15774015
15800014
15987703
16054041
16169070
16287113
16311241
16396636
16407220
16407837
16540748
16580634
16582077
16648371
16822578
16882735
16912160
16927138
16953221
17010524
17026623
17098823
17108107
17114342
17212587
17216128
17234589
17244606
17319781
17344591
17384680
17573348
17575127
17599048
17637250
17641416
17676035
17711506
17766436
17884763
17921699
17928927
17950019
18000088
18029348
18199157
18245474
18256292
18303014
18311138
18321849
18403917
18483235
18495044
18594528
18600394
18676680
18681789
18687677
18794113
18854309
18854318
19029933
19056867
19068194
19145097
19165201
19170196
19177591
19204826
19229701
19250387
19287990
19340305
19351817
19369417
19386264
19407487
19414597
19463221
19507030
19513107
19520843
19584313
19615099
19615732
19622832
19625176
19692168
19724060
19727776
19892943
19908348
20010869
20018878
20020146
20057966
20082862
20193846
20207041
20227367
20301443
20354225
20357370
20368287
20368693
20400510
20418665
20423848
20424326
20428811
20435009
20452353
20489196
20497868
20559149
20562859
20623358
20668229
20682687
20686846
20722467
20818976
20864035
20881644
20939895
20956321
20974850
21048031
21102257
21118512
21150337
21191146
21191700
21192934
21241696
21396365
21450399
21532627
21572398
21706049
21816872
21832049
21860411
21876548
21994947
22005930
22118009
22168747
22226967
22265968
22270359
22384927
22412893
22457270
22460425
22487816
22543132
22575644
22635025
22775437
22814264
22848740
22928647
22939624
22942091
22983157
22986809
22988252
23027127
23044421
23074285
23086944
23207623
23322200
23367447
23393134
23399955
23415580
23430953
23451056
23526220
23572524
23584481
23592276
23612973
23637231
23645358
23648482
23664447
23679304
23706335
23788249
23810581
23861764
23878245
23892522
24022664
24037887
24074562
24086281
24154639
24170201
24285539
24324551
24362629
24550282

Gene Ontology  (GO ID)

Biological Process

GO:0043276  anoikis
GO:0006914  autophagy
GO:0007409  axonogenesis
GO:0007050  cell cycle arrest
GO:0006112  energy reserve metabolic process
GO:0030010  establishment of cell polarity
GO:0042593  glucose homeostasis
GO:0051645  Golgi localization
GO:0008286  insulin receptor signaling pathway
GO:0030308  negative regulation of cell growth
GO:0008285  negative regulation of cell proliferation
GO:0060770  negative regulation of epithelial cell proliferation involved in prostate gland development
GO:0050772  positive regulation of axonogenesis
GO:0045722  positive regulation of gluconeogenesis
GO:0045860  positive regulation of protein kinase activity
GO:0030511  positive regulation of transforming growth factor beta receptor signaling pathway
GO:0046777  protein amino acid autophosphorylation
GO:0006468  protein amino acid phosphorylation
GO:0051291  protein heterooligomerization
GO:0001558  regulation of cell growth
GO:0042304  regulation of fatty acid biosynthetic process
GO:0051896  regulation of protein kinase B signaling cascade
GO:0030111  regulation of Wnt receptor signaling pathway
GO:0006974  response to DNA damage stimulus
GO:0033762  response to glucagon stimulus
GO:0010212  response to ionizing radiation
GO:0033993  response to lipid
GO:0007286  spermatid development
GO:0001894  tissue homeostasis
GO:0001944  vasculature development
GO:0060070  Wnt receptor signaling pathway through beta-catenin

Cellular Component

GO:0005737  cytoplasm
GO:0005829  cytosol
GO:0016020  membrane
GO:0005739  mitochondrion
GO:0005634  nucleus
GO:0043234  protein complex

Molecular Function

GO:0005524  ATP binding
GO:0042802  identical protein binding
GO:0030275  LRR domain binding
GO:0000287  magnesium ion binding
GO:0002039  p53 binding
GO:0005515  protein binding
GO:0032403  protein complex binding
GO:0030295  protein kinase activator activity
GO:0004674  protein serine/threonine kinase activity