synaptotagmin I

 jump to detail

Synonym

synaptotagmin I, DKFZp781D2042, SytI, SVP65, p65, SYT, Synaptotagmin-1, Synaptotagmin I, SYT1

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:418.40 cerebellum:428.20 brain stem:- corpus callosum/glia:58.30 pineal gland:593.40 peripheral nerve:122.70 spine:1010.70 retina:237.30 eye:176.30 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:19.70 adipose:- bone:12.80 skin:48
GeneChip cerebrum:9.92 cerebellum:10.29 brain stem:10.26 corpus callosum/glia:6.20 pineal gland:- peripheral nerve:7.44 spine:6.73 retina:- eye:- artery/aorta:4.48 vein:4.05 lymphnode:4.14 peripheral blood:- spleen:4.57 thymus:3.86 bone marrow:4.02 adipose:4.02 bone:- skin:3.96
CAGE cerebrum:5.04 cerebellum:- brain stem:3.39 corpus callosum/glia:3.01 pineal gland:5.03 peripheral nerve:- spine:2.62 retina:- eye:- artery/aorta:0.87 vein:1.03 lymphnode:0.23 peripheral blood:- spleen:1.15 thymus:0.28 bone marrow:- adipose:0.26 bone:- skin:-
RNA-seq cerebrum:0.22 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0.00 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.00 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:18.20 placenta:7.30 prostate:22.50 ovary:37.30 testis:8.70 heart:- muscle:- esophagus:- stomach:42.50 intestine:32.40 colon:67.80     liver/hepato:21.10        lung:19.60    bladder:- kidney:20.80 pituitary:347.90 thyroid/parathyroid:- adrenal gland:50.80 pancreas:- breast:158 salivary:-
GeneChip uterus:5.72 placenta:4.32 prostate:5.97 ovary:4.27 testis:3.95 heart:3.66 muscle:3.75 esophagus:4.34 stomach:4.36 intestine:4.78 colon:4.52 liver/hepato:3.89 lung:3.71 bladder:- kidney:4.13 pituitary:6.40 thyroid/parathyroid:3.84 adrenal gland:4.66 pancreas:4.25 breast:4.19 salivary:3.83
CAGE uterus:2.40 placenta:0.54 prostate:1.48 ovary:1.31 testis:0.67 heart:0.54 muscle:0.17 esophagus:0.97 stomach:- intestine:0.90 colon:1.07     liver/hepato:0.55    lung:0.05 bladder:1.32 kidney:0.62 pituitary:2.46 thyroid/parathyroid:0 adrenal gland:- pancreas:0 breast:0 salivary:0
RNA-seq uterus:- placenta:- prostate:0.00 ovary:0.00 testis:0.00 heart:0.00 muscle:0.00 esophagus:- stomach:- intestine:- colon:0.00     liver/hepato:0.00        lung:0.00    bladder:- kidney:0.00 pituitary:- thyroid/parathyroid:0.00 adrenal gland:0.00 pancreas:- breast:0.00 salivary:-

Gene Information

IDs

Refseq ID NM_001135805
Gene ID 6857
Unigene ID Hs.310545
Probe set ID 203999_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000067715
GTEx ID ENSG00000067715

Orthologous Gene

Mouse[2]  NM_009306
Rat [0]  

Chromosomal Region

12q21.2  [79,257,773  -  79,845,788]

Gene Family (Interpro ID)

IPR000008  C2 calcium-dependent membrane targeting
IPR008973  C2 calcium/lipid-binding domain, CaLB
IPR018029  C2 membrane targeting protein

Link to Pubmed  (Pubmed ID)

1326322
1840599
2446925
7553862
7624059
7798952
8071310
8087843
8769138
8889548
8901523
8999968
9010211
9303303
9712836
10397765
10692432
10734137
11181737
11242035
11243866
11381094
11432880
11438518
11438520
11438523
11454741
12062043
12089155
12135982
12477932
12750892
14702039
14709554
15082773
15466855
15467731
15489334
15603740
15919756
16143103
16169070
16344560
16525042
17307723
17956130
18779938
18937294
19186144
19234085
19234194
19284995
19523119
19557857
19835837
19926819
19953087
20098747
20195357
20222955
20379614
21139048
21906983
22360420
22475172
22705946
22853901
22890573
22966849
23071627
23251661
23341457
23607712
23932591
24302762

Gene Ontology  (GO ID)

Biological Process

GO:0005513  detection of calcium ion
GO:0014047  glutamate secretion
GO:0007269  neurotransmitter secretion
GO:0051260  protein homooligomerization
GO:0017158  regulation of calcium ion-dependent exocytosis
GO:0017157  regulation of exocytosis
GO:0007268  synaptic transmission
GO:0016079  synaptic vesicle exocytosis

Cellular Component

GO:0030054  cell junction
GO:0042584  chromaffin granule membrane
GO:0060201  clathrin sculpted acetylcholine transport vesicle membrane
GO:0060203  clathrin sculpted glutamate transport vesicle membrane
GO:0070083  clathrin sculpted monoamine transport vesicle membrane
GO:0031045  dense core granule
GO:0030666  endocytic vesicle membrane
GO:0060076  excitatory synapse
GO:0016021  integral to membrane
GO:0043005  neuron projection
GO:0005886  plasma membrane
GO:0042734  presynaptic membrane
GO:0008021  synaptic vesicle
GO:0030672  synaptic vesicle membrane

Molecular Function

GO:0005509  calcium ion binding
GO:0005544  calcium-dependent phospholipid binding
GO:0048306  calcium-dependent protein binding
GO:0005516  calmodulin binding
GO:0030276  clathrin binding
GO:0042802  identical protein binding
GO:0050750  low-density lipoprotein receptor binding
GO:0005545  phosphatidylinositol binding
GO:0005543  phospholipid binding
GO:0005515  protein binding
GO:0017075  syntaxin-1 binding
GO:0005215  transporter activity