ADAM metallopeptidase domain 17

Synonym

MGC71942, TNF-alpha convertase, CD156b, TACE, cSVP, ADAM17, A disintegrin and metalloproteinase domain 17, CD156B, alpha, ADAM 17 precursor, CSVP, TNF-alpha-converting enzyme, Snake venom-like protease, CD156b antigen

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:14.20

cerebellum:-

brain stem:-

corpus callosum/glia:29.20

pineal gland:-

peripheral nerve:-

spine:-

retina:118.60

eye:35.30

artery/aorta:-

vein:-

lymphnode:30.30

peripheral blood:-

spleen:56.70

thymus:38.70

bone marrow:39.40

adipose:40.30

bone:12.80

skin:33.60

GeneChip

cerebrum:6

cerebellum:6.58

brain stem:5.64

corpus callosum/glia:6.47

pineal gland:-

peripheral nerve:6.57

spine:6.46

retina:-

eye:-

artery/aorta:6.06

vein:6.17

lymphnode:6.53

peripheral blood:-

spleen:6.66

thymus:6.77

bone marrow:5.95

adipose:6.07

bone:-

skin:6.62

CAGE

cerebrum:2.84

cerebellum:-

brain stem:3.01

corpus callosum/glia:3.19

pineal gland:3.19

peripheral nerve:-

spine:3.04

retina:-

eye:-

artery/aorta:3.25

vein:3.02

lymphnode:3.31

peripheral blood:-

spleen:3.56

thymus:3.08

bone marrow:-

adipose:3.45

bone:-

skin:-

RNA-seq

cerebrum:2.78

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:3.22

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:4.02

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:63.80

placenta:14.60

prostate:22.50

ovary:37.30

testis:34.60

heart:-

muscle:-

esophagus:-

stomach:127.50

intestine:-

colon:25.40

liver/hepato:31.70

lung:34.20

bladder:-

kidney:20.80

pituitary:-

thyroid/parathyroid:-

adrenal gland:-

pancreas:-

breast:65.10

salivary:-

GeneChip

uterus:6.18

placenta:6.78

prostate:5.88

ovary:6.64

testis:6.60

heart:6.10

muscle:5.66

esophagus:6.33

stomach:5.85

intestine:5.79

colon:5.70

liver/hepato:5.59

lung:7.41

bladder:-

kidney:5.89

pituitary:5.87

thyroid/parathyroid:6.45

adrenal gland:6

pancreas:4.69

breast:6.91

salivary:5.25

CAGE

uterus:3.21

placenta:3.83

prostate:2.75

ovary:3.43

testis:3.40

heart:3.16

muscle:2.44

esophagus:3.24

stomach:-

intestine:2.91

colon:2.93

liver/hepato:2.55

lung:3.69

bladder:3.06

kidney:3.05

pituitary:2.85

thyroid/parathyroid:3.00

adrenal gland:-

pancreas:2.76

breast:3.33

salivary:2.97

RNA-seq

uterus:-

placenta:-

prostate:2.69

ovary:3.54

testis:3.53

heart:2.39

muscle:2.62

esophagus:-

stomach:-

intestine:-

colon:2.84

liver/hepato:1.61

lung:3.61

bladder:-

kidney:2.67

pituitary:-

thyroid/parathyroid:3.48

adrenal gland:2.97

pancreas:-

breast:3.00

salivary:-

IDs

Refseq ID	NM_003183
Gene ID	6868
Unigene ID	Hs.404914
Probe set ID	205745_x_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000151694
GTEx ID	ENSG00000151694

Orthologous Gene

Mouse[3]	NM_009615
Rat [0]

Chromosomal Region

2p25.1 [9,628,615 - 9,695,921]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

Gene Ontology (GO ID)

Biological Process

GO:0006915	apoptosis
GO:0030183	B cell differentiation
GO:0007155	cell adhesion
GO:0033627	cell adhesion mediated by integrin
GO:0048870	cell motility
GO:0030574	collagen catabolic process
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0022617	extracellular matrix disassembly
GO:0030198	extracellular matrix organization
GO:0002467	germinal center formation
GO:0060397	JAK-STAT cascade involved in growth hormone signaling pathway
GO:0006509	membrane protein ectodomain proteolysis
GO:0031293	membrane protein intracellular domain proteolysis
GO:0032717	negative regulation of interleukin-8 production
GO:0048011	nerve growth factor receptor signaling pathway
GO:0002446	neutrophil mediated immunity
GO:0007219	Notch signaling pathway
GO:0051088	PMA-inducible membrane protein ectodomain proteolysis
GO:0030307	positive regulation of cell growth
GO:0030335	positive regulation of cell migration
GO:0008284	positive regulation of cell proliferation
GO:0051272	positive regulation of cellular component movement
GO:0032722	positive regulation of chemokine production
GO:0031659	positive regulation of cyclin-dependent protein kinase activity during G1/S
GO:0045741	positive regulation of epidermal growth factor receptor activity
GO:0002690	positive regulation of leukocyte chemotaxis
GO:0001934	positive regulation of protein amino acid phosphorylation
GO:0010820	positive regulation of T cell chemotaxis
GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway
GO:0033025	regulation of mast cell apoptosis
GO:0042493	response to drug
GO:0055099	response to high density lipoprotein stimulus
GO:0001666	response to hypoxia
GO:0032496	response to lipopolysaccharide
GO:0048536	spleen development
GO:0033077	T cell differentiation in the thymus
GO:0035313	wound healing, spreading of epidermal cells

Cellular Component

GO:0015629	actin cytoskeleton
GO:0016324	apical plasma membrane
GO:0009986	cell surface
GO:0005911	cell-cell junction
GO:0005737	cytoplasm
GO:0005925	focal adhesion
GO:0005887	integral to plasma membrane
GO:0045121	membrane raft
GO:0005886	plasma membrane
GO:0032587	ruffle membrane

Molecular Function

GO:0005178	integrin binding
GO:0005138	interleukin-6 receptor binding
GO:0004222	metalloendopeptidase activity
GO:0008237	metallopeptidase activity
GO:0030165	PDZ domain binding
GO:0005515	protein binding
GO:0017124	SH3 domain binding
GO:0008270	zinc ion binding

ADAM metallopeptidase domain 17

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function