T-cell acute lymphocytic leukemia 1

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Synonym

TCL5, T-cell acute lymphocytic leukemia-1 protein, Stem cell protein, TAL1, T-cell leukemia/lymphoma-5 protein, T-cell acute lymphocytic leukemia 1, tal-1, TAL-1 protein

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST nodata
GeneChip cerebrum:4.78 cerebellum:4.43 brain stem:5.08 corpus callosum/glia:5.12 pineal gland:- peripheral nerve:4.45 spine:4.98 retina:- eye:- artery/aorta:4.88 vein:4.54 lymphnode:4.67 peripheral blood:- spleen:5.31 thymus:4.44 bone marrow:8.44 adipose:4.87 bone:- skin:5.07
CAGE cerebrum:1.56 cerebellum:- brain stem:2.29 corpus callosum/glia:2.73 pineal gland:1.32 peripheral nerve:- spine:2.24 retina:- eye:- artery/aorta:1.03 vein:1.98 lymphnode:0.86 peripheral blood:- spleen:1.71 thymus:0.28 bone marrow:- adipose:2.34 bone:- skin:-
RNA-seq cerebrum:0.57 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:1.96 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:1.70 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST nodata
GeneChip uterus:4.65 placenta:4.78 prostate:4.44 ovary:4.64 testis:4.25 heart:4.68 muscle:4.63 esophagus:4.47 stomach:4.56 intestine:4.49 colon:4.83 liver/hepato:4.41 lung:6.50 bladder:- kidney:4.62 pituitary:4.33 thyroid/parathyroid:5.03 adrenal gland:4.85 pancreas:4.30 breast:4.80 salivary:4.31
CAGE uterus:1.63 placenta:1.69 prostate:1.36 ovary:1.25 testis:1.08 heart:1.91 muscle:1.23 esophagus:1.20 stomach:- intestine:1.15 colon:0.69     liver/hepato:0.71    lung:2.65 bladder:1.21 kidney:0.98 pituitary:0.43 thyroid/parathyroid:1.34 adrenal gland:- pancreas:0.94 breast:2.27 salivary:0.83
RNA-seq uterus:- placenta:- prostate:0.75 ovary:0.77 testis:0.99 heart:1.13 muscle:0.13 esophagus:- stomach:- intestine:- colon:1.01     liver/hepato:0.57        lung:2.44    bladder:- kidney:1.02 pituitary:- thyroid/parathyroid:1.00 adrenal gland:2.00 pancreas:- breast:1.52 salivary:-

Gene Information

IDs

Refseq ID NM_003189
Gene ID 6886
Unigene ID -
Probe set ID 206283_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000162367
GTEx ID ENSG00000162367

Orthologous Gene

Mouse[1]  NM_011527
Rat[1]  NM_001107958

Chromosomal Region

1p33  [47,681,963  -  47,697,892]

Gene Family (Interpro ID)

-

Link to Pubmed  (Pubmed ID)

1311214
1396592
1450410
1453013
1886719
1964581
2230650
2247063
2303035
2602361
2740341
7568177
7678994
7833471
7957052
8078932
8084606
8159721
8414504
8423803
8437851
8576241
8889548
9111058
9171354
9209374
9242638
9507011
9819382
9824680
10383400
10490830
10688671
10866689
11118214
11904294
12010791
12091340
12239153
12477932
12704079
12867998
14651981
14715640
14729962
14970264
15086455
15383276
15677454
15920471
15923636
15961517
16007160
16298389
16407974
16621969
16710414
16763211
16778171
16849639
17460775
17474147
17503961
17507663
17878155
17910069
17962192
18187418
18436863
18439091
18495761
18550854
19406989
19497860
19527627
19587703
19785037
19865112
19913121
20028976
20140202
20603019
20628086
20855495
21179004
21407147
21474105
21571218
21647153
21937587
21988832
22310283
22773876
22897851
22982397
23327922
23448994
23698277
23857984
24040098
24200685
24249258
24395799
24470145

Gene Ontology  (GO ID)

Biological Process

GO:0001525  angiogenesis
GO:0060018  astrocyte fate commitment
GO:0030221  basophil differentiation
GO:0045165  cell fate commitment
GO:0060216  definitive hemopoiesis
GO:0035162  embryonic hemopoiesis
GO:0030218  erythrocyte differentiation
GO:0043249  erythrocyte maturation
GO:0060217  hemangioblast cell differentiation
GO:0030097  hemopoiesis
GO:0060218  hemopoietic stem cell differentiation
GO:0007626  locomotory behavior
GO:0030219  megakaryocyte differentiation
GO:0000122  negative regulation of transcription from RNA polymerase II promoter
GO:0030220  platelet formation
GO:0051781  positive regulation of cell division
GO:0045799  positive regulation of chromatin assembly or disassembly
GO:0045648  positive regulation of erythrocyte differentiation
GO:0045931  positive regulation of mitotic cell cycle
GO:0031334  positive regulation of protein complex assembly
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0042127  regulation of cell proliferation
GO:0060375  regulation of mast cell differentiation
GO:0006357  regulation of transcription from RNA polymerase II promoter
GO:0021527  spinal cord association neuron differentiation

Cellular Component

GO:0000118  histone deacetylase complex
GO:0033193  Lsd1/2 complex
GO:0000790  nuclear chromatin
GO:0005634  nucleus
GO:0005667  transcription factor complex

Molecular Function

GO:0003682  chromatin binding
GO:0044212  DNA regulatory region binding
GO:0070888  E-box binding
GO:0019899  enzyme binding
GO:0042826  histone deacetylase binding
GO:0005515  protein binding
GO:0046982  protein heterodimerization activity
GO:0003700  transcription factor activity