transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)

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Synonym

Y1, Peptide transporter TAP2, ATP-binding cassette sub-family B member 3, Peptide transporter PSF2, TAP2, RING11, Peptide supply factor 2, PSF-2, Antigen peptide transporter 2, ABC18, APT2, PSF2, ABCB3, D6S217E

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:15.40 cerebellum:- brain stem:- corpus callosum/glia:29.20 pineal gland:- peripheral nerve:30.70 spine:112.30 retina:- eye:5.90 artery/aorta:119.90 vein:- lymphnode:151.70 peripheral blood:- spleen:- thymus:- bone marrow:19.70 adipose:- bone:12.80 skin:38.40
GeneChip cerebrum:3.68 cerebellum:3.57 brain stem:3.76 corpus callosum/glia:3.63 pineal gland:- peripheral nerve:3.49 spine:3.60 retina:- eye:- artery/aorta:3.69 vein:3.79 lymphnode:3.56 peripheral blood:- spleen:3.54 thymus:3.38 bone marrow:3.83 adipose:3.62 bone:- skin:3.75
CAGE cerebrum:2.60 cerebellum:- brain stem:2.79 corpus callosum/glia:2.84 pineal gland:2.72 peripheral nerve:- spine:2.71 retina:- eye:- artery/aorta:2.85 vein:3.63 lymphnode:3.65 peripheral blood:- spleen:3.91 thymus:3.80 bone marrow:- adipose:3.37 bone:- skin:-
RNA-seq cerebrum:0 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:54.70 placenta:120.20 prostate:45.10 ovary:111.80 testis:30.30 heart:25.50 muscle:20.10 esophagus:- stomach:21.20 intestine:- colon:25.40     liver/hepato:-        lung:34.20    bladder:- kidney:114.40 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:65.10 salivary:-
GeneChip uterus:3.52 placenta:3.61 prostate:3.38 ovary:3.49 testis:3.38 heart:3.63 muscle:3.77 esophagus:3.60 stomach:3.65 intestine:3.72 colon:3.93 liver/hepato:3.79 lung:3.68 bladder:- kidney:3.68 pituitary:3.58 thyroid/parathyroid:3.58 adrenal gland:3.59 pancreas:3.64 breast:3.54 salivary:4.17
CAGE uterus:3.16 placenta:2.69 prostate:2.98 ovary:3.14 testis:2.30 heart:3.01 muscle:2.45 esophagus:3.56 stomach:- intestine:4.01 colon:3.20     liver/hepato:3.49    lung:3.75 bladder:2.68 kidney:3.11 pituitary:2.57 thyroid/parathyroid:3.38 adrenal gland:- pancreas:2.18 breast:2.59 salivary:2.66
RNA-seq uterus:- placenta:- prostate:0 ovary:0 testis:0 heart:0 muscle:0 esophagus:- stomach:- intestine:- colon:0     liver/hepato:0        lung:0    bladder:- kidney:0 pituitary:- thyroid/parathyroid:0 adrenal gland:0 pancreas:- breast:0 salivary:-

Gene Information

IDs

Refseq ID NM_018833
Gene ID 6891
Unigene ID Hs.502004
Probe set ID 208428_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000204267
GTEx ID ENSG00000204267

Orthologous Gene

Mouse[1]  NM_011530
Rat [0]  

Chromosomal Region

HSCHR6_MHC_APD  [32,765,310  -  32,790,204]
6p21.32  [32,781,544  -  32,806,599]
HSCHR6_MHC_COX  [32,703,870  -  32,728,923]
HSCHR6_MHC_QBL  [32,718,320  -  32,735,268]
HSCHR6_MHC_MCF  [32,815,048  -  32,840,077]
HSCHR6_MHC_DBB  [32,759,673  -  32,784,578]
HSCHR6_MHC_MANN  [32,943,409  -  32,960,357]
HSCHR6_MHC_SSTO  [32,871,619  -  32,896,512]

Gene Family (Interpro ID)

IPR017940  ABC transporter integral membrane type 1
IPR013305  ABC transporter, ABCB2
IPR013306  ABC transporter, B3
IPR011527  ABC transporter, transmembrane domain, type 1
IPR003439  ABC transporter-like
IPR005293  Antigen peptide transporter 2
IPR003593  ATPase, AAA+ type, core
IPR014745  MHC class II, alpha/beta chain, N-terminal
IPR000353  MHC class II, beta chain, N-terminal
IPR011162  MHC classes I/II-like antigen recognition protein

Link to Pubmed  (Pubmed ID)

1453454
1529427
1538751
1570316
1741401
1946428
2259383
7517574
7538543
7673167
7792761
7835969
8125298
8162639
8428770
8453065
8458375
8496691
8568858
8670825
8773329
8805302
8955196
9002450
9103419
9175839
9324024
9427624
9551969
9672156
9916708
10227971
10508608
10560675
10605026
10835348
11096258
11133832
11157746
11229461
11294565
11381133
11494532
11532960
11737038
11774612
11775239
11916171
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12018331
12026214
12047361
12047747
12202157
12213826
12225333
12234057
12477932
12485523
12505156
12507827
12594855
12634240
12645939
12648225
12648282
12682044
12687213
12717621
12729048
12777379
12777979
12786997
12786999
12826376
12911283
12963978
14558951
14679198
14749980
15318034
15336779
15343265
15385740
15488952
15489334
15518576
15548263
15887980
16061226
16112028
16174096
16191421
16210614
16215317
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16356928
16395595
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16634865
16690408
16721835
16828748
16886895
16923719
17055437
17068338
17192492
17245734
17491658
17525827
17581627
17703412
17947644
17982230
18029348
18071882
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18309376
18385764
18433405
18650831
18694960
18764808
18976687
19116923
19148137
19188174
19202550
19217216
19258923
19263211
19297616
19343046
19387463
19404951
19480848
19549407
19609238
19851445
19913121
19946888
20083708
20193774
20204276
20439763
20453000
20470844
20503287
20525414
20587610
20628086
21139048
21399633
21440064
21796142
21832049
21843574
21890473
21906983
21963094
21987572
21988832
22065046
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22638925
22911334
22989262
23000965
23028341
23182705
23189151
23302073
23349640
23449627
24196954
24288424
24501197
24816145

Gene Ontology  (GO ID)

Biological Process

GO:0019885  antigen processing and presentation of endogenous peptide antigen via MHC class I
GO:0002485  antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent
GO:0002489  antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent
GO:0042590  antigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0002479  antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0002481  antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
GO:0002474  antigen processing and presentation of peptide antigen via MHC class I
GO:0046967  cytosol to ER transport
GO:0019060  intracellular transport of viral proteins in host cell
GO:0046968  peptide antigen transport
GO:0015833  peptide transport
GO:0002591  positive regulation of antigen processing and presentation of peptide antigen via MHC class I
GO:0001916  positive regulation of T cell mediated cytotoxicity
GO:0055085  transmembrane transport

Cellular Component

GO:0005783  endoplasmic reticulum
GO:0005789  endoplasmic reticulum membrane
GO:0030176  integral to endoplasmic reticulum membrane
GO:0016021  integral to membrane
GO:0005743  mitochondrial inner membrane
GO:0005634  nucleus
GO:0005886  plasma membrane
GO:0042825  TAP complex

Molecular Function

GO:0005524  ATP binding
GO:0042288  MHC class I protein binding
GO:0015421  oligopeptide-transporting ATPase activity
GO:0042605  peptide antigen binding
GO:0015433  peptide antigen-transporting ATPase activity
GO:0015197  peptide transporter activity
GO:0005515  protein binding
GO:0046978  TAP1 binding
GO:0046979  TAP2 binding
GO:0046980  tapasin binding
GO:0005215  transporter activity