T-box 5

 jump to detail

Synonym

T-box protein 5, TBX5, T-box transcription factor TBX5, T-box 5, HOS

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:1.20 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:9.60
GeneChip cerebrum:5.41 cerebellum:5.50 brain stem:5.55 corpus callosum/glia:5.23 pineal gland:- peripheral nerve:5.11 spine:5.26 retina:- eye:- artery/aorta:5.32 vein:5.48 lymphnode:5.34 peripheral blood:- spleen:5.01 thymus:5.24 bone marrow:5.32 adipose:5.38 bone:- skin:5.33
CAGE cerebrum:0.14 cerebellum:- brain stem:0.19 corpus callosum/glia:0.24 pineal gland:0 peripheral nerve:- spine:0.22 retina:- eye:- artery/aorta:0.34 vein:0.79 lymphnode:0.46 peripheral blood:- spleen:0 thymus:0 bone marrow:- adipose:1.12 bone:- skin:-
RNA-seq cerebrum:0.00 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0.71 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.11 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:105.60 prostate:11.30 ovary:- testis:- heart:76.60 muscle:- esophagus:- stomach:21.20 intestine:- colon:-     liver/hepato:-        lung:58.70    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip uterus:5.05 placenta:4.98 prostate:5.05 ovary:5.11 testis:5.19 heart:6.13 muscle:5.65 esophagus:5.14 stomach:5.13 intestine:5.17 colon:5.47 liver/hepato:5.26 lung:5.23 bladder:- kidney:5.36 pituitary:5.16 thyroid/parathyroid:5.01 adrenal gland:5.23 pancreas:5.74 breast:5.10 salivary:5.40
CAGE uterus:0.24 placenta:2.58 prostate:1.95 ovary:0 testis:0 heart:3.13 muscle:0 esophagus:1.98 stomach:- intestine:0 colon:0     liver/hepato:0    lung:2.88 bladder:2.02 kidney:0 pituitary:0 thyroid/parathyroid:0.32 adrenal gland:- pancreas:0 breast:1.53 salivary:0
RNA-seq uterus:- placenta:- prostate:2.09 ovary:0.00 testis:0.05 heart:3.00 muscle:0.00 esophagus:- stomach:- intestine:- colon:0.00     liver/hepato:0        lung:2.53    bladder:- kidney:0 pituitary:- thyroid/parathyroid:0.02 adrenal gland:0 pancreas:- breast:1.18 salivary:-

Gene Information

IDs

Refseq ID NM_181486
Gene ID 6910
Unigene ID Hs.381715
Probe set ID 211886_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000089225
GTEx ID ENSG00000089225

Orthologous Gene

Mouse[2]  NM_011537
Rat[1]  NM_001009964

Chromosomal Region

12q24.21  [114,791,736  -  114,846,247]

Gene Family (Interpro ID)

IPR001699  Transcription factor, T-box

Link to Pubmed  (Pubmed ID)

8054982
8988164
8988165
10077612
10199965
10842287
10974675
11161571
11183182
11431700
11748310
12237100
12477932
12499378
12668595
12818525
12845333
12858531
14519429
15087119
15138308
15221798
15489334
15591049
15653675
16183809
16332960
16344560
16917909
17273972
17534187
17584735
18378906
18451335
18701034
18726671
18828908
19187613
19336370
19430479
19586889
19648116
19913121
20062060
20062063
20301290
20379614
20414254
20450920
20519243
20628086
20677014
20802524
20975709
21045733
21076409
21752519
21909110
22011241
22192413
22333898
22414880
22532574
22543974
22589738
22837378
22901678
23139255
23245941
23251661
23535732
23717681

Gene Ontology  (GO ID)

Biological Process

GO:0030262  apoptotic nuclear changes
GO:0003283  atrial septum development
GO:0003181  atrioventricular valve morphogenesis
GO:0003166  bundle of His development
GO:0003218  cardiac left ventricle formation
GO:0055007  cardiac muscle cell differentiation
GO:0060980  cell migration involved in coronary vasculogenesis
GO:0007267  cell-cell signaling
GO:0035115  embryonic forelimb morphogenesis
GO:0030326  embryonic limb morphogenesis
GO:0003197  endocardial cushion development
GO:0035136  forelimb morphogenesis
GO:0010467  gene expression
GO:0007507  heart development
GO:0030324  lung development
GO:0002009  morphogenesis of an epithelium
GO:0060044  negative regulation of cardiac muscle cell proliferation
GO:0030336  negative regulation of cell migration
GO:0008285  negative regulation of cell proliferation
GO:0010719  negative regulation of epithelial to mesenchymal transition
GO:0007389  pattern specification process
GO:0060039  pericardium development
GO:0060045  positive regulation of cardiac muscle cell proliferation
GO:0051891  positive regulation of cardioblast differentiation
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0006367  transcription initiation from RNA polymerase II promoter
GO:0003229  ventricular cardiac muscle tissue development
GO:0003281  ventricular septum development

Cellular Component

GO:0005737  cytoplasm
GO:0005654  nucleoplasm
GO:0005634  nucleus
GO:0005667  transcription factor complex

Molecular Function

GO:0003677  DNA binding
GO:0005515  protein binding
GO:0043565  sequence-specific DNA binding
GO:0003700  transcription factor activity
GO:0008134  transcription factor binding