zinc finger E-box binding homeobox 1

Synonym

Zfhx1a, NIL-2A, NIL-2-A, ZEB1, ZFHEP, AREB6, ZEB, MGC133261, Negative regulator of IL2, Zfhep, TCF8, ZFHX1A, BZP, Transcription factor 8, NIL-2-A zinc finger protein

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:79.40

cerebellum:12.60

brain stem:-

corpus callosum/glia:58.30

pineal gland:-

peripheral nerve:30.70

spine:112.30

retina:474.60

eye:47

artery/aorta:269.80

vein:133.30

lymphnode:70.80

peripheral blood:109.30

spleen:-

thymus:154.60

bone marrow:59

adipose:80.70

bone:51.20

skin:38.40

GeneChip

cerebrum:7.39

cerebellum:6.59

brain stem:7.65

corpus callosum/glia:7.32

pineal gland:-

peripheral nerve:8.02

spine:7.89

retina:-

eye:-

artery/aorta:8.67

vein:8.05

lymphnode:6.64

peripheral blood:-

spleen:6.31

thymus:8.15

bone marrow:5.34

adipose:7.74

bone:-

skin:6.65

CAGE

cerebrum:3.51

cerebellum:-

brain stem:3.53

corpus callosum/glia:3.25

pineal gland:4.08

peripheral nerve:-

spine:4.30

retina:-

eye:-

artery/aorta:3.88

vein:3.78

lymphnode:2.82

peripheral blood:-

spleen:3.19

thymus:4.15

bone marrow:-

adipose:4.13

bone:-

skin:-

RNA-seq

cerebrum:0.77

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:0.19

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:0.39

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:164

placenta:58.30

prostate:22.50

ovary:74.50

testis:73.50

heart:102.20

muscle:80.40

esophagus:-

stomach:85

intestine:64.80

colon:-

liver/hepato:137.20

lung:78.20

bladder:-

kidney:83.20

pituitary:116

thyroid/parathyroid:-

adrenal gland:-

pancreas:17.80

breast:18.60

salivary:-

GeneChip

uterus:8.80

placenta:6.39

prostate:7.56

ovary:7.14

testis:5.90

heart:8.20

muscle:8.16

esophagus:6.31

stomach:7.43

intestine:7.24

colon:6.78

liver/hepato:5.79

lung:7.18

bladder:-

kidney:5.42

pituitary:6.71

thyroid/parathyroid:6.76

adrenal gland:6.85

pancreas:4.87

breast:7.13

salivary:5.03

CAGE

uterus:4.43

placenta:2.93

prostate:4.26

ovary:3.66

testis:3.05

heart:4.01

muscle:4.62

esophagus:4.06

stomach:-

intestine:3.09

colon:3.16

liver/hepato:2.42

lung:3.52

bladder:5.16

kidney:2.95

pituitary:3.59

thyroid/parathyroid:3.04

adrenal gland:-

pancreas:0.58

breast:3.43

salivary:1.75

RNA-seq

uterus:-

placenta:-

prostate:0.15

ovary:0.00

testis:0.59

heart:0.07

muscle:0

esophagus:-

stomach:-

intestine:-

colon:0.79

liver/hepato:0.01

lung:0.06

bladder:-

kidney:0

pituitary:-

thyroid/parathyroid:0.36

adrenal gland:0.29

pancreas:-

breast:0.45

salivary:-

IDs

Refseq ID	NM_001128128
Gene ID	6935
Unigene ID	Hs.124503
Probe set ID	212764_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000148516
GTEx ID	ENSG00000148516

Orthologous Gene

Mouse[1]	NM_011546
Rat[2]	NM_013164

Chromosomal Region

10p11.22 [31,607,747 - 31,821,599]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

IPR001356	Homeobox
IPR009057	Homeodomain-like
IPR012287	Homeodomain-related
IPR015880	Zinc finger, C2H2-like
IPR007087	Zinc finger, C2H2-type

Gene Ontology (GO ID)

Biological Process

GO:0051216	cartilage development
GO:0008283	cell proliferation
GO:0071230	cellular response to amino acid stimulus
GO:0090103	cochlea morphogenesis
GO:0048596	embryonic camera-type eye morphogenesis
GO:0048704	embryonic skeletal system morphogenesis
GO:0030900	forebrain development
GO:0006955	immune response
GO:0008285	negative regulation of cell proliferation
GO:0030857	negative regulation of epithelial cell differentiation
GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0045892	negative regulation of transcription, DNA-dependent
GO:0007389	pattern specification process
GO:0045666	positive regulation of neuron differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0010464	regulation of mesenchymal cell proliferation
GO:0051150	regulation of smooth muscle cell differentiation
GO:0033081	regulation of T cell differentiation in the thymus
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0017015	regulation of transforming growth factor beta receptor signaling pathway
GO:0014823	response to activity
GO:0031667	response to nutrient levels
GO:0048752	semicircular canal morphogenesis
GO:0006351	transcription, DNA-dependent

Cellular Component

GO:0005737	cytoplasm
GO:0005730	nucleolus
GO:0005634	nucleus
GO:0005667	transcription factor complex

Molecular Function

GO:0003682	chromatin binding
GO:0003690	double-stranded DNA binding
GO:0070888	E-box binding
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding
GO:0003713	transcription coactivator activity
GO:0003714	transcription corepressor activity
GO:0003700	transcription factor activity
GO:0008134	transcription factor binding
GO:0008270	zinc ion binding

zinc finger E-box binding homeobox 1

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function