TEK tyrosine kinase, endothelial

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Synonym

CD202B, TIE2, VMCM1, CD202b antigen, Angiopoietin-1 receptor precursor, VMCM, TEK, p140 TEK, hTIE2, CD202b, Tunica interna endothelial cell kinase, TIE-2, Tyrosine-protein kinase receptor TIE-2, Tyrosine-protein kinase receptor TEK

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:23.70 cerebellum:50.40 brain stem:- corpus callosum/glia:29.20 pineal gland:- peripheral nerve:61.30 spine:- retina:- eye:11.80 artery/aorta:149.90 vein:66.60 lymphnode:- peripheral blood:- spleen:37.80 thymus:25.80 bone marrow:- adipose:- bone:38.40 skin:4.80
GeneChip cerebrum:5.37 cerebellum:4.90 brain stem:5.28 corpus callosum/glia:5.31 pineal gland:- peripheral nerve:5.25 spine:5.14 retina:- eye:- artery/aorta:6.75 vein:6.22 lymphnode:5.70 peripheral blood:- spleen:8.06 thymus:4.74 bone marrow:5.06 adipose:6.74 bone:- skin:5.84
CAGE cerebrum:2.28 cerebellum:- brain stem:2.36 corpus callosum/glia:2.41 pineal gland:2.51 peripheral nerve:- spine:2.36 retina:- eye:- artery/aorta:2.94 vein:2.99 lymphnode:1.95 peripheral blood:- spleen:3.88 thymus:0.91 bone marrow:- adipose:4.10 bone:- skin:-
RNA-seq cerebrum:1.93 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:3.31 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:3.83 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:118.50 placenta:61.90 prostate:- ovary:- testis:17.30 heart:- muscle:- esophagus:- stomach:- intestine:32.40 colon:-     liver/hepato:10.60        lung:39.10    bladder:125.60 kidney:52 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:27.90 salivary:-
GeneChip uterus:6.25 placenta:7.18 prostate:5.56 ovary:5.43 testis:4.66 heart:6.86 muscle:5.99 esophagus:5.13 stomach:5.93 intestine:5.97 colon:5.59 liver/hepato:5.85 lung:8.99 bladder:- kidney:7.27 pituitary:5.01 thyroid/parathyroid:5.92 adrenal gland:7.22 pancreas:4.85 breast:5.71 salivary:4.73
CAGE uterus:3.37 placenta:3.85 prostate:2.60 ovary:2.69 testis:1.84 heart:3.68 muscle:2.60 esophagus:2.74 stomach:- intestine:2.17 colon:2.07     liver/hepato:2.83    lung:4.22 bladder:2.43 kidney:3.90 pituitary:2.51 thyroid/parathyroid:2.62 adrenal gland:- pancreas:2.34 breast:3.64 salivary:1.58
RNA-seq uterus:- placenta:- prostate:2.44 ovary:2.38 testis:2.21 heart:2.81 muscle:1.53 esophagus:- stomach:- intestine:- colon:3.07     liver/hepato:2.22        lung:5.31    bladder:- kidney:3.95 pituitary:- thyroid/parathyroid:2.94 adrenal gland:3.37 pancreas:- breast:3.29 salivary:-

Gene Information

IDs

Refseq ID NM_000459
Gene ID 7010
Unigene ID Hs.89640
Probe set ID 206702_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000120156
GTEx ID ENSG00000120156

Orthologous Gene

Mouse[1]  NM_013690
Rat[1]  NM_001105737

Chromosomal Region

9p21.2  [27,109,139  -  27,230,173]

Gene Family (Interpro ID)

IPR000742  EGF-like, type 3
IPR003961  Fibronectin, type III
IPR008957  Fibronectin, type III-like fold
IPR000719  Protein kinase, catalytic domain
IPR011009  Protein kinase-like domain
IPR002290  Serine/threonine-protein kinase domain
IPR017442  Serine/threonine-protein kinase-like domain
IPR001245  Tyrosine-protein kinase, catalytic domain
IPR020635  Tyrosine-protein kinase, subgroup, catalytic domain

Link to Pubmed  (Pubmed ID)

1312667
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Gene Ontology  (GO ID)

Biological Process

GO:0001525  angiogenesis
GO:0007596  blood coagulation
GO:0016337  cell-cell adhesion
GO:0007267  cell-cell signaling
GO:0007160  cell-matrix adhesion
GO:0060216  definitive hemopoiesis
GO:0001935  endothelial cell proliferation
GO:0007507  heart development
GO:0060347  heart trabecula formation
GO:0050900  leukocyte migration
GO:0016525  negative regulation of angiogenesis
GO:0043066  negative regulation of apoptosis
GO:0050728  negative regulation of inflammatory response
GO:0018108  peptidyl-tyrosine phosphorylation
GO:0045766  positive regulation of angiogenesis
GO:0010595  positive regulation of endothelial cell migration
GO:0001938  positive regulation of endothelial cell proliferation
GO:0070374  positive regulation of ERK1 and ERK2 cascade
GO:0051894  positive regulation of focal adhesion formation
GO:0033138  positive regulation of peptidyl-serine phosphorylation
GO:0043552  positive regulation of phosphoinositide 3-kinase activity
GO:0014068  positive regulation of phosphoinositide 3-kinase cascade
GO:0001934  positive regulation of protein amino acid phosphorylation
GO:0051897  positive regulation of protein kinase B signaling cascade
GO:0010740  positive regulation of protein kinase cascade
GO:0046777  protein amino acid autophosphorylation
GO:0051259  protein oligomerization
GO:0032878  regulation of establishment or maintenance of cell polarity
GO:0043114  regulation of vascular permeability
GO:0007165  signal transduction
GO:0002040  sprouting angiogenesis
GO:0034446  substrate adhesion-dependent cell spreading
GO:0048014  Tie receptor signaling pathway
GO:0007169  transmembrane receptor protein tyrosine kinase signaling pathway

Cellular Component

GO:0005884  actin filament
GO:0016324  apical plasma membrane
GO:0009925  basal plasma membrane
GO:0016323  basolateral plasma membrane
GO:0009986  cell surface
GO:0005911  cell-cell junction
GO:0005737  cytoplasm
GO:0005576  extracellular region
GO:0005925  focal adhesion
GO:0005887  integral to plasma membrane
GO:0045121  membrane raft
GO:0005902  microvillus
GO:0005886  plasma membrane
GO:0001725  stress fiber

Molecular Function

GO:0005524  ATP binding
GO:0005515  protein binding
GO:0004672  protein kinase activity
GO:0004713  protein tyrosine kinase activity
GO:0004872  receptor activity
GO:0004714  transmembrane receptor protein tyrosine kinase activity