TEK tyrosine kinase, endothelial

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Synonym

CD202B, TIE2, VMCM1, CD202b antigen, Angiopoietin-1 receptor precursor, VMCM, TEK, p140 TEK, hTIE2, CD202b, Tunica interna endothelial cell kinase, TIE-2, Tyrosine-protein kinase receptor TIE-2, Tyrosine-protein kinase receptor TEK

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:23.70 cerebellum:50.40 brain stem:- corpus callosum/glia:29.20 pineal gland:- peripheral nerve:61.30 spine:- retina:- eye:11.80 artery/aorta:149.90 vein:66.60 lymphnode:- peripheral blood:- spleen:37.80 thymus:25.80 bone marrow:- adipose:- bone:38.40 skin:4.80
GeneChip cerebrum:5.37 cerebellum:4.90 brain stem:5.28 corpus callosum/glia:5.31 pineal gland:- peripheral nerve:5.25 spine:5.14 retina:- eye:- artery/aorta:6.75 vein:6.22 lymphnode:5.70 peripheral blood:- spleen:8.06 thymus:4.74 bone marrow:5.06 adipose:6.74 bone:- skin:5.84
CAGE cerebrum:2.28 cerebellum:- brain stem:2.36 corpus callosum/glia:2.41 pineal gland:2.51 peripheral nerve:- spine:2.36 retina:- eye:- artery/aorta:2.94 vein:2.99 lymphnode:1.95 peripheral blood:- spleen:3.88 thymus:0.91 bone marrow:- adipose:4.10 bone:- skin:-
RNA-seq cerebrum:1.93 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:3.31 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:3.83 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:118.50 placenta:61.90 prostate:- ovary:- testis:17.30 heart:- muscle:- esophagus:- stomach:- intestine:32.40 colon:-     liver/hepato:10.60        lung:39.10    bladder:125.60 kidney:52 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:27.90 salivary:-
GeneChip uterus:6.25 placenta:7.18 prostate:5.56 ovary:5.43 testis:4.66 heart:6.86 muscle:5.99 esophagus:5.13 stomach:5.93 intestine:5.97 colon:5.59 liver/hepato:5.85 lung:8.99 bladder:- kidney:7.27 pituitary:5.01 thyroid/parathyroid:5.92 adrenal gland:7.22 pancreas:4.85 breast:5.71 salivary:4.73
CAGE uterus:3.37 placenta:3.85 prostate:2.60 ovary:2.69 testis:1.84 heart:3.68 muscle:2.60 esophagus:2.74 stomach:- intestine:2.17 colon:2.07     liver/hepato:2.83    lung:4.22 bladder:2.43 kidney:3.90 pituitary:2.51 thyroid/parathyroid:2.62 adrenal gland:- pancreas:2.34 breast:3.64 salivary:1.58
RNA-seq uterus:- placenta:- prostate:2.44 ovary:2.38 testis:2.21 heart:2.81 muscle:1.53 esophagus:- stomach:- intestine:- colon:3.07     liver/hepato:2.22        lung:5.31    bladder:- kidney:3.95 pituitary:- thyroid/parathyroid:2.94 adrenal gland:3.37 pancreas:- breast:3.29 salivary:-

IDs

Refseq ID NM_000459
Gene ID 7010
Unigene ID Hs.89640
Probe set ID 206702_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000120156
GTEx ID ENSG00000120156

Orthologous Gene

Mouse[1]  NM_013690
Rat[1]  NM_001105737

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed  (Pubmed ID)

1312667
7478529
7545683
7783168
7829101
7833915
7835909
8382358
8980223
8980224
8980225
9204896
9632797
9660821
9710115
9723709
9764820
10022833
10051567
10369874
10521483
10557082
10766762
10995770
11080633
11397875
11470823
11513602
11689432
11733376
11824375
11866538
11967990
12107410
12138242
12419314
12427764
12477932
12609966
12665569
12711329
12731667
12816861
12878859
12887596
13130465
14665640
14726409
14749497
14991531
14991534
15210451
15242771
15284220
15297853
15340161
15370298
15377998
15536413
15542434
15746084
15769741
15781448
15802272
15817662
15893672
15893943
15985432
16020388
16037627
16049136
16157706
16457819
16458662
16614513
16723371
16756945
16830384
16895971
16956819
16978237
16978614
17035633
17258205
17322632
17327411
17446561
17504972
17513791
17562701
17704802
17724803
17728252
17901375
18269030
18366015
18401423
18425119
18425120
18519826
18570117
18593464
18675456
18807212
18996102
19079259
19082594
19116766
19167335
19186995
19223473
19339208
19340004
19351722
19421150
19424712
19451274
19487284
19515812
19543148
19576253
19615361
19674970
19689429
19733541
19875484
19888299
19922791
20026268
20054548
20056911
20098747
20099495
20164029
20191124
20227369
20301733
20348331
20379614
20519501
20602615
20696814
21042788
21097670
21173154
21212269
21273558
21321379
21366713
21368233
21400522
21525162
21575447
21576085
21672190
21832049
21849906
21858161
21884204
21962923
22235284
22326430
22342979
22449617
22465760
22585576
22621187
22728324
22836649
22848540
22996814
23086340
23123737
23149917
23174599
23190105
23382691
23504320
23566851
23602568
23633549
23652985
23754070
23754286
23770419
23840065
23982963
24023872
24254563
24308939
24333662

Gene Ontology  (GO ID)

Biological Process

GO:0001525  angiogenesis
GO:0007596  blood coagulation
GO:0016337  cell-cell adhesion
GO:0007267  cell-cell signaling
GO:0007160  cell-matrix adhesion
GO:0060216  definitive hemopoiesis
GO:0001935  endothelial cell proliferation
GO:0007507  heart development
GO:0060347  heart trabecula formation
GO:0050900  leukocyte migration
GO:0016525  negative regulation of angiogenesis
GO:0043066  negative regulation of apoptosis
GO:0050728  negative regulation of inflammatory response
GO:0018108  peptidyl-tyrosine phosphorylation
GO:0045766  positive regulation of angiogenesis
GO:0010595  positive regulation of endothelial cell migration
GO:0001938  positive regulation of endothelial cell proliferation
GO:0070374  positive regulation of ERK1 and ERK2 cascade
GO:0051894  positive regulation of focal adhesion formation
GO:0033138  positive regulation of peptidyl-serine phosphorylation
GO:0043552  positive regulation of phosphoinositide 3-kinase activity
GO:0014068  positive regulation of phosphoinositide 3-kinase cascade
GO:0001934  positive regulation of protein amino acid phosphorylation
GO:0051897  positive regulation of protein kinase B signaling cascade
GO:0010740  positive regulation of protein kinase cascade
GO:0046777  protein amino acid autophosphorylation
GO:0051259  protein oligomerization
GO:0032878  regulation of establishment or maintenance of cell polarity
GO:0043114  regulation of vascular permeability
GO:0007165  signal transduction
GO:0002040  sprouting angiogenesis
GO:0034446  substrate adhesion-dependent cell spreading
GO:0048014  Tie receptor signaling pathway
GO:0007169  transmembrane receptor protein tyrosine kinase signaling pathway

Cellular Component

GO:0005884  actin filament
GO:0016324  apical plasma membrane
GO:0009925  basal plasma membrane
GO:0016323  basolateral plasma membrane
GO:0009986  cell surface
GO:0005911  cell-cell junction
GO:0005737  cytoplasm
GO:0005576  extracellular region
GO:0005925  focal adhesion
GO:0005887  integral to plasma membrane
GO:0045121  membrane raft
GO:0005902  microvillus
GO:0005886  plasma membrane
GO:0001725  stress fiber

Molecular Function

GO:0005524  ATP binding
GO:0005515  protein binding
GO:0004672  protein kinase activity
GO:0004713  protein tyrosine kinase activity
GO:0004872  receptor activity
GO:0004714  transmembrane receptor protein tyrosine kinase activity