transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)

Synonym

TFAP2, AP-2, Transcription factor AP-2 alpha, Activator protein 2, AP2TF, Activating enhancer-binding protein 2 alpha, AP2-alpha, TFAP2A, AP-2 transcription factor, AP-2alpha

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:4.70

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:30.70

spine:-

retina:237.30

eye:176.30

artery/aorta:-

vein:-

lymphnode:-

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:-

bone:-

skin:67.20

GeneChip

cerebrum:4.20

cerebellum:5.26

brain stem:4.21

corpus callosum/glia:4.22

pineal gland:-

peripheral nerve:5.93

spine:4.41

retina:-

eye:-

artery/aorta:4.19

vein:4.50

lymphnode:5.04

peripheral blood:-

spleen:4.14

thymus:4.25

bone marrow:4.47

adipose:4.65

bone:-

skin:7.92

CAGE

cerebrum:0.57

cerebellum:-

brain stem:0.53

corpus callosum/glia:0.24

pineal gland:2.11

peripheral nerve:-

spine:0.86

retina:-

eye:-

artery/aorta:2.34

vein:0.88

lymphnode:2.17

peripheral blood:-

spleen:0.17

thymus:0.61

bone marrow:-

adipose:0.46

bone:-

skin:-

RNA-seq

cerebrum:0.15

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:0.00

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:0.04

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:-

placenta:258.70

prostate:56.30

ovary:-

testis:13

heart:-

muscle:-

esophagus:-

stomach:-

intestine:-

colon:8.50

liver/hepato:-

lung:19.60

bladder:-

kidney:41.60

pituitary:-

thyroid/parathyroid:-

adrenal gland:-

pancreas:-

breast:241.60

salivary:-

GeneChip

uterus:4.52

placenta:10.56

prostate:6.64

ovary:3.95

testis:4.51

heart:4.37

muscle:4.35

esophagus:7.54

stomach:4.40

intestine:4.33

colon:4.74

liver/hepato:4.06

lung:4.10

bladder:-

kidney:6.37

pituitary:4.10

thyroid/parathyroid:4.09

adrenal gland:4.08

pancreas:4.61

breast:9.01

salivary:8.04

CAGE

uterus:2.13

placenta:6.16

prostate:3.24

ovary:0.72

testis:1.78

heart:0.83

muscle:0.09

esophagus:4.28

stomach:-

intestine:0.69

colon:0.51

liver/hepato:0.14

lung:1.35

bladder:2.41

kidney:3.24

pituitary:0.38

thyroid/parathyroid:0.45

adrenal gland:-

pancreas:0

breast:3.99

salivary:4.51

RNA-seq

uterus:-

placenta:-

prostate:1.42

ovary:0.13

testis:1.03

heart:0.00

muscle:0

esophagus:-

stomach:-

intestine:-

colon:0.19

liver/hepato:0.04

lung:0.32

bladder:-

kidney:1.99

pituitary:-

thyroid/parathyroid:0.08

adrenal gland:0.04

pancreas:-

breast:1.77

salivary:-

IDs

Refseq ID	NM_001042425
Gene ID	7020
Unigene ID	Hs.519880
Probe set ID	204653_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000137203
GTEx ID	ENSG00000137203

Orthologous Gene

Mouse[6]	NM_001122948, NM_011547
Rat[1]	NM_001107345, NM_011547

Chromosomal Region

6p24.3 [10,393,419 - 10,419,892]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

Gene Ontology (GO ID)

Biological Process

GO:0021506	anterior neuropore closure
GO:0060349	bone morphogenesis
GO:0071281	cellular response to iron ion
GO:0010172	embryonic body morphogenesis
GO:0048701	embryonic cranial skeleton morphogenesis
GO:0035115	embryonic forelimb morphogenesis
GO:0009880	embryonic pattern specification
GO:0048730	epidermis morphogenesis
GO:0060325	face morphogenesis
GO:0021884	forebrain neuron development
GO:0042472	inner ear morphogenesis
GO:0003334	keratinocyte development
GO:0001822	kidney development
GO:0060235	lens induction in camera-type eye
GO:0043066	negative regulation of apoptosis
GO:0008285	negative regulation of cell proliferation
GO:0042059	negative regulation of epidermal growth factor receptor signaling pathway
GO:0010944	negative regulation of transcription by competitive promoter binding
GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0045892	negative regulation of transcription, DNA-dependent
GO:0014032	neural crest cell development
GO:0021623	oculomotor nerve formation
GO:0003409	optic cup structural organization
GO:0003404	optic vesicle morphogenesis
GO:0003151	outflow tract morphogenesis
GO:0060021	palate development
GO:0030501	positive regulation of bone mineralization
GO:0030335	positive regulation of cell migration
GO:0010628	positive regulation of gene expression
GO:0043525	positive regulation of neuron apoptosis
GO:0070172	positive regulation of tooth mineralization
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0045893	positive regulation of transcription, DNA-dependent
GO:0045595	regulation of cell differentiation
GO:0045664	regulation of neuron differentiation
GO:0010842	retina layer formation
GO:0007605	sensory perception of sound
GO:0048485	sympathetic nervous system development
GO:0006366	transcription from RNA polymerase II promoter
GO:0021559	trigeminal nerve development

Cellular Component

GO:0005813	centrosome
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0043231	intracellular membrane-bounded organelle
GO:0005730	nucleolus
GO:0005634	nucleus

Molecular Function

GO:0003682	chromatin binding
GO:0044212	DNA regulatory region binding
GO:0005515	protein binding
GO:0046983	protein dimerization activity
GO:0042803	protein homodimerization activity
GO:0043565	sequence-specific DNA binding
GO:0003713	transcription coactivator activity

transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function