transforming growth factor, beta 2

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Synonym

Polyergin, TGFbeta2, TGF beta2, transforming growth factor, beta 2, TGF beta(2), G-TSF, BSC-1 cell growth inhibitor, TGFB2, TGF-beta-2, MGC116892, Cetermin, TGF beta 2, TGF-beta2, Transforming growth factor beta-2 precursor, TGFb2, Glioblastoma-derived T-cell suppressor factor

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:41.50 cerebellum:50.40 brain stem:- corpus callosum/glia:262.50 pineal gland:- peripheral nerve:245.40 spine:- retina:237.30 eye:58.80 artery/aorta:30 vein:- lymphnode:- peripheral blood:- spleen:37.80 thymus:- bone marrow:- adipose:- bone:89.60 skin:76.80
GeneChip cerebrum:2.85 cerebellum:2.78 brain stem:2.73 corpus callosum/glia:3.09 pineal gland:- peripheral nerve:2.67 spine:3.05 retina:- eye:- artery/aorta:3.27 vein:3.52 lymphnode:2.69 peripheral blood:- spleen:2.70 thymus:2.58 bone marrow:2.69 adipose:2.72 bone:- skin:2.91
CAGE cerebrum:4.23 cerebellum:- brain stem:3.74 corpus callosum/glia:4.28 pineal gland:3.31 peripheral nerve:- spine:5.39 retina:- eye:- artery/aorta:4.55 vein:3.04 lymphnode:1.13 peripheral blood:- spleen:2.16 thymus:0.91 bone marrow:- adipose:1.97 bone:- skin:-
RNA-seq cerebrum:0.34 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0.00 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.00 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:54.70 placenta:25.50 prostate:33.80 ovary:- testis:- heart:12.80 muscle:- esophagus:- stomach:- intestine:- colon:8.50     liver/hepato:21.10        lung:63.50    bladder:125.60 kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:50.80 pancreas:- breast:232.30 salivary:-
GeneChip uterus:3.26 placenta:3.12 prostate:3.45 ovary:2.96 testis:2.73 heart:2.78 muscle:3.28 esophagus:2.70 stomach:2.72 intestine:2.89 colon:2.71 liver/hepato:2.75 lung:3.08 bladder:- kidney:2.64 pituitary:2.77 thyroid/parathyroid:2.68 adrenal gland:2.66 pancreas:2.85 breast:2.87 salivary:2.82
CAGE uterus:4.22 placenta:3.60 prostate:4.31 ovary:3.13 testis:2.21 heart:3.17 muscle:3.71 esophagus:2.65 stomach:- intestine:1.82 colon:2.17     liver/hepato:1.16    lung:3.74 bladder:3.48 kidney:2.26 pituitary:3.49 thyroid/parathyroid:2.96 adrenal gland:- pancreas:2.48 breast:2.69 salivary:4.04
RNA-seq uterus:- placenta:- prostate:0.00 ovary:0.15 testis:0.61 heart:0.10 muscle:0.00 esophagus:- stomach:- intestine:- colon:0.00     liver/hepato:0.00        lung:0.00    bladder:- kidney:0.37 pituitary:- thyroid/parathyroid:0.35 adrenal gland:0.00 pancreas:- breast:0.00 salivary:-

Gene Information

IDs

Refseq ID NM_001135599
Gene ID 7042
Unigene ID Hs.133379
Probe set ID 209909_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000092969
GTEx ID ENSG00000092969

Orthologous Gene

Mouse[3]  NM_009367
Rat[1]  NM_031131

Chromosomal Region

1q41  [218,519,577  -  218,617,961]

Gene Family (Interpro ID)

IPR001111  Transforming growth factor beta (TGFb), N-terminal
IPR015618  Transforming growth factor beta 3
IPR003911  Transforming growth factor beta TGFb
IPR003940  Transforming growth factor, beta 2
IPR016319  Transforming growth factor-beta
IPR015615  Transforming growth factor-beta-related

Link to Pubmed  (Pubmed ID)

1333888
1631557
1641027
1764261
2119582
2850146
3162414
3226728
3322813
3457014
3476488
7513640
7852346
8093006
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12060393
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12064833
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12420205
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12867422
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15247411
15290353
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15489334
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16608413
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17201588
17217916
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20201926
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23322721
23387555
23651239
23668958
23687438
23690072
23712828
24045946
24311892
24314882

Gene Ontology  (GO ID)

Biological Process

GO:0032147  activation of protein kinase activity
GO:0006924  activation-induced cell death of T cells
GO:0001525  angiogenesis
GO:0007411  axon guidance
GO:0007596  blood coagulation
GO:0001974  blood vessel remodeling
GO:0060317  cardiac epithelial to mesenchymal transition
GO:0060038  cardiac muscle cell proliferation
GO:0010002  cardioblast differentiation
GO:0001502  cartilage condensation
GO:0042637  catagen
GO:0007050  cell cycle arrest
GO:0008219  cell death
GO:0016049  cell growth
GO:0016477  cell migration
GO:0000902  cell morphogenesis
GO:0008283  cell proliferation
GO:0045216  cell-cell junction organization
GO:0007267  cell-cell signaling
GO:0030199  collagen fibril organization
GO:0042416  dopamine biosynthetic process
GO:0009790  embryonic development
GO:0048566  embryonic gut development
GO:0001837  epithelial to mesenchymal transition
GO:0030198  extracellular matrix organization
GO:0001654  eye development
GO:0060325  face morphogenesis
GO:0048699  generation of neurons
GO:0008347  glial cell migration
GO:0001942  hair follicle development
GO:0031069  hair follicle morphogenesis
GO:0007507  heart development
GO:0003007  heart morphogenesis
GO:0030097  hemopoiesis
GO:0006917  induction of apoptosis
GO:0022601  menstrual cycle phase
GO:0010693  negative regulation of alkaline phosphatase activity
GO:0030308  negative regulation of cell growth
GO:0008285  negative regulation of cell proliferation
GO:0050680  negative regulation of epithelial cell proliferation
GO:0050777  negative regulation of immune response
GO:0010936  negative regulation of macrophage cytokine production
GO:0048666  neuron development
GO:0048663  neuron fate commitment
GO:0030593  neutrophil chemotaxis
GO:0042476  odontogenesis
GO:0060389  pathway-restricted SMAD protein phosphorylation
GO:0030168  platelet activation
GO:0002576  platelet degranulation
GO:0051891  positive regulation of cardioblast differentiation
GO:0051795  positive regulation of catagen
GO:0033630  positive regulation of cell adhesion mediated by integrin
GO:0045787  positive regulation of cell cycle
GO:0051781  positive regulation of cell division
GO:0030307  positive regulation of cell growth
GO:0008284  positive regulation of cell proliferation
GO:0010634  positive regulation of epithelial cell migration
GO:0010718  positive regulation of epithelial to mesenchymal transition
GO:0010628  positive regulation of gene expression
GO:0045823  positive regulation of heart contraction
GO:0050778  positive regulation of immune response
GO:0045726  positive regulation of integrin biosynthetic process
GO:0043525  positive regulation of neuron apoptosis
GO:0045778  positive regulation of ossification
GO:0014068  positive regulation of phosphoinositide 3-kinase cascade
GO:0050714  positive regulation of protein secretion
GO:0032874  positive regulation of stress-activated MAPK cascade
GO:0006468  protein amino acid phosphorylation
GO:0032909  regulation of transforming growth factor-beta2 production
GO:0042493  response to drug
GO:0001666  response to hypoxia
GO:0032570  response to progesterone stimulus
GO:0009611  response to wounding
GO:0007435  salivary gland morphogenesis
GO:0007184  SMAD protein nuclear translocation
GO:0048103  somatic stem cell division
GO:0007179  transforming growth factor beta receptor signaling pathway
GO:0042060  wound healing

Cellular Component

GO:0030424  axon
GO:0043025  cell soma
GO:0031012  extracellular matrix
GO:0005576  extracellular region
GO:0005615  extracellular space
GO:0031093  platelet alpha granule lumen

Molecular Function

GO:0001540  beta-amyloid binding
GO:0005125  cytokine activity
GO:0008083  growth factor activity
GO:0005515  protein binding
GO:0046982  protein heterodimerization activity
GO:0042803  protein homodimerization activity
GO:0005102  receptor binding
GO:0004702  receptor signaling protein serine/threonine kinase activity
GO:0005160  transforming growth factor beta receptor binding
GO:0005114  type II transforming growth factor beta receptor binding