transforming growth factor, beta 3

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Synonym

Transforming growth factor beta-3 precursor, TGF-beta-3, TGFbeta3, TGF beta(3), transforming growth factor, beta 3, TGFbeta 3, TGF beta3, TGFB3, TGFb3, FLJ16571, ARVD, TGF beta 3, TGF-beta3

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:20.10 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:61.30 spine:- retina:- eye:47 artery/aorta:30 vein:- lymphnode:- peripheral blood:- spleen:37.80 thymus:12.90 bone marrow:19.70 adipose:40.30 bone:12.80 skin:9.60
GeneChip cerebrum:6.83 cerebellum:6.33 brain stem:6.78 corpus callosum/glia:7.21 pineal gland:- peripheral nerve:6.19 spine:6.89 retina:- eye:- artery/aorta:7.15 vein:8.33 lymphnode:6.55 peripheral blood:- spleen:6 thymus:5.73 bone marrow:6.13 adipose:6.87 bone:- skin:6.13
CAGE cerebrum:2.26 cerebellum:- brain stem:3.04 corpus callosum/glia:3.25 pineal gland:1.52 peripheral nerve:- spine:2.69 retina:- eye:- artery/aorta:3.16 vein:2.35 lymphnode:2.32 peripheral blood:- spleen:0.80 thymus:1.36 bone marrow:- adipose:1.93 bone:- skin:-
RNA-seq cerebrum:2.88 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:3.85 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:2.34 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:63.80 placenta:54.60 prostate:169 ovary:74.50 testis:8.70 heart:76.60 muscle:- esophagus:- stomach:21.20 intestine:- colon:25.40     liver/hepato:21.10        lung:24.40    bladder:- kidney:41.60 pituitary:- thyroid/parathyroid:- adrenal gland:50.80 pancreas:53.30 breast:27.90 salivary:-
GeneChip uterus:7.01 placenta:6.97 prostate:7.44 ovary:6.24 testis:5.87 heart:7.03 muscle:6.90 esophagus:6.15 stomach:6.64 intestine:6.60 colon:6.81 liver/hepato:6.25 lung:6.62 bladder:- kidney:6.20 pituitary:6.49 thyroid/parathyroid:6.33 adrenal gland:6.96 pancreas:6.85 breast:6.82 salivary:6.25
CAGE uterus:3.00 placenta:3.19 prostate:4.16 ovary:2.39 testis:1.95 heart:3.00 muscle:2.59 esophagus:1.89 stomach:- intestine:1.29 colon:1.29     liver/hepato:3.09    lung:2.13 bladder:3.35 kidney:1.99 pituitary:1.82 thyroid/parathyroid:1.78 adrenal gland:- pancreas:1.98 breast:0 salivary:0.62
RNA-seq uterus:- placenta:- prostate:3.54 ovary:2.73 testis:4.12 heart:2.47 muscle:4.26 esophagus:- stomach:- intestine:- colon:3.13     liver/hepato:1.55        lung:5.01    bladder:- kidney:2.32 pituitary:- thyroid/parathyroid:2.95 adrenal gland:4.22 pancreas:- breast:2.62 salivary:-

Gene Information

IDs

Refseq ID NM_003239
Gene ID 7043
Unigene ID Hs.592317
Probe set ID 209747_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000119699
GTEx ID ENSG00000119699

Orthologous Gene

Mouse[1]  NM_009368
Rat [0]  

Chromosomal Region

14q24.3  [76,424,442  -  76,449,334]

Gene Family (Interpro ID)

IPR001111  Transforming growth factor beta (TGFb), N-terminal
IPR015618  Transforming growth factor beta 3
IPR003911  Transforming growth factor beta TGFb
IPR003940  Transforming growth factor, beta 2
IPR016319  Transforming growth factor-beta
IPR015615  Transforming growth factor-beta-related

Link to Pubmed  (Pubmed ID)

1326540
1333888
1875922
3164476
3208746
3226728
3457014
7493022
7796607
7852346
7951245
7962292
8093006
8106553
8819159
8886879
9140123
9250163
9683588
9872992
10187774
10457363
10930463
11157754
11158066
11166150
11199370
11341298
11374028
11382746
11384957
11488419
11754469
11776328
11821050
11850637
11969342
12021923
12060054
12062452
12168782
12171249
12221089
12358597
12410804
12432546
12477932
12489185
12508121
12607775
12651933
12652527
12729750
12733956
12772773
12911534
14659070
14679171
14702039
15017149
15155569
15247411
15639475
15896309
15924806
16043141
16210002
16247549
16549496
16778279
16781676
16930538
17225872
17272867
17401695
17671384
17673689
17827158
18039789
18049952
18078367
18080134
18156205
18174230
18243111
18293167
18480962
18498721
18505915
18698632
18799618
18950289
18976975
19062040
19107876
19161338
19212830
19231643
19322201
19328471
19336475
19396528
19432813
19453261
19628198
19651533
19656717
19700613
19787410
19897194
19937272
20082468
20083094
20142847
20170386
20237132
20237496
20301310
20407224
20408761
20485444
20497023
20572854
20587546
20613589
20628624
20634891
20672350
20734064
20736064
20945347
21041550
21084396
21177256
21305699
21352603
21411746
21423151
21611961
21666950
21988832
22143699
22191848
22266274
22369552
22409215
22464821
22674391
22706080
22795539
22796605
22880017
23023602
23122986
23824657
23968981
24053560
24056369
24306208

Gene Ontology  (GO ID)

Biological Process

GO:0000187  activation of MAPK activity
GO:0007568  aging
GO:0007596  blood coagulation
GO:0016049  cell growth
GO:0045216  cell-cell junction organization
GO:0070483  detection of hypoxia
GO:0048702  embryonic neurocranium morphogenesis
GO:0030198  extracellular matrix organization
GO:0060325  face morphogenesis
GO:0007565  female pregnancy
GO:0060364  frontal suture morphogenesis
GO:0048565  gut development
GO:0001701  in utero embryonic development
GO:0006917  induction of apoptosis
GO:0048839  inner ear development
GO:0048286  lung alveolus development
GO:0030879  mammary gland development
GO:0022601  menstrual cycle phase
GO:0008285  negative regulation of cell proliferation
GO:0008156  negative regulation of DNA replication
GO:0010936  negative regulation of macrophage cytokine production
GO:0043524  negative regulation of neuron apoptosis
GO:0030512  negative regulation of transforming growth factor beta receptor signaling pathway
GO:0042476  odontogenesis
GO:0043932  ossification involved in bone remodeling
GO:0060021  palate development
GO:0030168  platelet activation
GO:0002576  platelet degranulation
GO:0043065  positive regulation of apoptosis
GO:0030501  positive regulation of bone mineralization
GO:0051781  positive regulation of cell division
GO:0032967  positive regulation of collagen biosynthetic process
GO:0045740  positive regulation of DNA replication
GO:0010718  positive regulation of epithelial to mesenchymal transition
GO:0051491  positive regulation of filopodium assembly
GO:0010862  positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0050714  positive regulation of protein secretion
GO:0060391  positive regulation of SMAD protein nuclear translocation
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0043627  response to estrogen stimulus
GO:0001666  response to hypoxia
GO:0034616  response to laminar fluid shear stress
GO:0032570  response to progesterone stimulus
GO:0007435  salivary gland morphogenesis
GO:0007184  SMAD protein nuclear translocation
GO:0007179  transforming growth factor beta receptor signaling pathway

Cellular Component

GO:0043025  cell soma
GO:0009986  cell surface
GO:0031012  extracellular matrix
GO:0005576  extracellular region
GO:0005615  extracellular space
GO:0005634  nucleus
GO:0005886  plasma membrane
GO:0031093  platelet alpha granule lumen
GO:0030315  T-tubule

Molecular Function

GO:0008083  growth factor activity
GO:0042802  identical protein binding
GO:0005515  protein binding
GO:0046982  protein heterodimerization activity
GO:0050431  transforming growth factor beta binding
GO:0034713  type I transforming growth factor beta receptor binding
GO:0005114  type II transforming growth factor beta receptor binding