transforming growth factor, beta receptor II (70/80kDa)

Synonym

type II TGF-b receptor, TGFBR2, TGF beta RII, TGF-beta type II receptor, TGF-beta R2, TAAD2, AAT3, TGF-b type II receptor, type II transforming growth factor beta receptor, TGFbeta type II receptor, TGFbeta R2, TGFb receptor type II, TGFR-2, TGF-beta RII, TGFBRII, TGFbeta RII, RIIC, TGFbeta receptor type II, HNPCC6, MFS2, TGFbetaRII, type II TGFb receptor, TGF-b receptor type II, FAA3, TGFbRII, TGF beta R2, TGF-beta receptor type-2 precursor, TGFb type II receptor, TGF-beta receptor type II, TGFbeta-RII, type II TGFbeta receptor, type II TGF beta receptor

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:21.30

cerebellum:12.60

brain stem:-

corpus callosum/glia:58.30

pineal gland:-

peripheral nerve:490.80

spine:224.60

retina:237.30

eye:41.10

artery/aorta:119.90

vein:-

lymphnode:101.10

peripheral blood:91.10

spleen:75.60

thymus:25.80

bone marrow:295.20

adipose:80.70

bone:140.70

skin:67.20

GeneChip

cerebrum:6.19

cerebellum:5.05

brain stem:6.58

corpus callosum/glia:6.60

pineal gland:-

peripheral nerve:9.15

spine:6.93

retina:-

eye:-

artery/aorta:9.15

vein:9.46

lymphnode:9.06

peripheral blood:-

spleen:9.65

thymus:8.25

bone marrow:7.82

adipose:9.94

bone:-

skin:8.72

CAGE

cerebrum:3.53

cerebellum:-

brain stem:4.07

corpus callosum/glia:4.19

pineal gland:4.45

peripheral nerve:-

spine:4.38

retina:-

eye:-

artery/aorta:5.92

vein:5.78

lymphnode:5.65

peripheral blood:-

spleen:6.06

thymus:4.65

bone marrow:-

adipose:6.40

bone:-

skin:-

RNA-seq

cerebrum:2.33

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:7.17

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:6.54

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:182.30

placenta:94.70

prostate:56.30

ovary:37.30

testis:26

heart:76.60

muscle:-

esophagus:-

stomach:106.20

intestine:162

colon:152.60

liver/hepato:31.70

lung:68.40

bladder:251.20

kidney:207.90

pituitary:-

thyroid/parathyroid:163.70

adrenal gland:-

pancreas:106.70

breast:55.80

salivary:-

GeneChip

uterus:8.90

placenta:8.21

prostate:8.17

ovary:8.36

testis:5.73

heart:9.45

muscle:7.46

esophagus:8.07

stomach:9.29

intestine:8.80

colon:8.93

liver/hepato:7.82

lung:9.88

bladder:-

kidney:8.88

pituitary:6.28

thyroid/parathyroid:8.77

adrenal gland:9.41

pancreas:8.26

breast:9.08

salivary:7.90

CAGE

uterus:5.61

placenta:4.68

prostate:5.47

ovary:4.96

testis:4.27

heart:5.91

muscle:4.68

esophagus:5.45

stomach:-

intestine:4.92

colon:5.55

liver/hepato:4.78

lung:5.99

bladder:5.72

kidney:5.29

pituitary:4.18

thyroid/parathyroid:5.37

adrenal gland:-

pancreas:5.02

breast:6.37

salivary:4.61

RNA-seq

uterus:-

placenta:-

prostate:6.40

ovary:4.26

testis:4.88

heart:5.71

muscle:4.02

esophagus:-

stomach:-

intestine:-

colon:6.92

liver/hepato:4.24

lung:6.28

bladder:-

kidney:5.85

pituitary:-

thyroid/parathyroid:5.05

adrenal gland:6.48

pancreas:-

breast:6.18

salivary:-

IDs

Refseq ID	NM_003242
Gene ID	7048
Unigene ID	Hs.82028
Probe set ID	208944_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000163513
GTEx ID	ENSG00000163513

Orthologous Gene

Mouse[4]	NM_009371, NM_029575
Rat[1]	NM_031132, NM_029575

Chromosomal Region

3p24.1 [30,647,994 - 30,735,634]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

IPR000333	Activin type II receptor
IPR000719	Protein kinase, catalytic domain
IPR011009	Protein kinase-like domain
IPR002290	Serine/threonine-protein kinase domain
IPR017442	Serine/threonine-protein kinase-like domain
IPR017194	Transforming growth factor-beta receptor, type II
IPR001245	Tyrosine-protein kinase, catalytic domain
IPR020635	Tyrosine-protein kinase, subgroup, catalytic domain

Gene Ontology (GO ID)

Biological Process

GO:0032147	activation of protein kinase activity
GO:0007568	aging
GO:0006915	apoptosis
GO:0001568	blood vessel development
GO:0007420	brain development
GO:0060434	bronchus morphogenesis
GO:0051216	cartilage development
GO:0007182	common-partner SMAD protein phosphorylation
GO:0007566	embryo implantation
GO:0048701	embryonic cranial skeleton morphogenesis
GO:0035162	embryonic hemopoiesis
GO:0007369	gastrulation
GO:0048565	gut development
GO:0007507	heart development
GO:0001701	in utero embryonic development
GO:0006917	induction of apoptosis
GO:0002088	lens development in camera-type eye
GO:0060463	lung lobe morphogenesis
GO:0060443	mammary gland morphogenesis
GO:0043011	myeloid dendritic cell differentiation
GO:0060044	negative regulation of cardiac muscle cell proliferation
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway
GO:0031100	organ regeneration
GO:0060021	palate development
GO:0060389	pathway-restricted SMAD protein phosphorylation
GO:0001569	patterning of blood vessels
GO:0018105	peptidyl-serine phosphorylation
GO:0018107	peptidyl-threonine phosphorylation
GO:0002663	positive regulation of B cell tolerance induction
GO:0008284	positive regulation of cell proliferation
GO:0010634	positive regulation of epithelial cell migration
GO:0002053	positive regulation of mesenchymal cell proliferation
GO:0051138	positive regulation of NK T cell differentiation
GO:0043415	positive regulation of skeletal muscle tissue regeneration
GO:0048661	positive regulation of smooth muscle cell proliferation
GO:0002666	positive regulation of T cell tolerance induction
GO:0002651	positive regulation of tolerance induction to self antigen
GO:0006468	protein amino acid phosphorylation
GO:0006898	receptor-mediated endocytosis
GO:0042127	regulation of cell proliferation
GO:0070723	response to cholesterol
GO:0042493	response to drug
GO:0043627	response to estrogen stimulus
GO:0009749	response to glucose stimulus
GO:0009612	response to mechanical stimulus
GO:0007584	response to nutrient
GO:0007224	smoothened signaling pathway
GO:0060440	trachea formation
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0001570	vasculogenesis
GO:0042060	wound healing

Cellular Component

GO:0005901	caveola
GO:0005829	cytosol
GO:0009897	external side of plasma membrane
GO:0016021	integral to membrane
GO:0005886	plasma membrane
GO:0043235	receptor complex
GO:0070022	transforming growth factor beta receptor complex

Molecular Function

GO:0005524	ATP binding
GO:0005539	glycosaminoglycan binding
GO:0046872	metal ion binding
GO:0031435	mitogen-activated protein kinase kinase kinase binding
GO:0005515	protein binding
GO:0004702	receptor signaling protein serine/threonine kinase activity
GO:0046332	SMAD binding
GO:0050431	transforming growth factor beta binding
GO:0005024	transforming growth factor beta receptor activity
GO:0005026	transforming growth factor beta receptor activity, type II
GO:0004675	transmembrane receptor protein serine/threonine kinase activity
GO:0034713	type I transforming growth factor beta receptor binding
GO:0034714	type III transforming growth factor beta receptor binding

transforming growth factor, beta receptor II (70/80kDa)

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function