thrombospondin 1

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Synonym

THBS1, Thrombospondin-1 precursor, TSP, thrombospondin 1, TSP1, THBS

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:26.10 cerebellum:- brain stem:- corpus callosum/glia:583.20 pineal gland:- peripheral nerve:184 spine:224.60 retina:237.30 eye:70.50 artery/aorta:1498.80 vein:799.80 lymphnode:50.60 peripheral blood:109.30 spleen:18.90 thymus:51.50 bone marrow:255.80 adipose:161.30 bone:870.10 skin:259.20
GeneChip cerebrum:2.95 cerebellum:2.93 brain stem:3.45 corpus callosum/glia:2.76 pineal gland:- peripheral nerve:7.56 spine:4.83 retina:- eye:- artery/aorta:7.18 vein:9.43 lymphnode:6.27 peripheral blood:- spleen:7.13 thymus:3.93 bone marrow:5.70 adipose:7.42 bone:- skin:6.48
CAGE cerebrum:2.54 cerebellum:- brain stem:2.97 corpus callosum/glia:3.08 pineal gland:3.37 peripheral nerve:- spine:3.10 retina:- eye:- artery/aorta:5.65 vein:4.85 lymphnode:5.27 peripheral blood:- spleen:6.04 thymus:1.96 bone marrow:- adipose:5.69 bone:- skin:-
RNA-seq cerebrum:3.14 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:5.96 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:7.94 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:264.30 placenta:134.80 prostate:202.80 ovary:149.10 testis:8.70 heart:76.60 muscle:- esophagus:- stomach:297.40 intestine:32.40 colon:356.10     liver/hepato:95        lung:195.50    bladder:251.20 kidney:249.50 pituitary:- thyroid/parathyroid:163.70 adrenal gland:50.80 pancreas:88.90 breast:659.80 salivary:-
GeneChip uterus:8.10 placenta:7.63 prostate:7.76 ovary:8.07 testis:3.27 heart:7.18 muscle:3.50 esophagus:5.05 stomach:7.04 intestine:7.25 colon:6.77 liver/hepato:4.77 lung:9.27 bladder:- kidney:7.47 pituitary:4.89 thyroid/parathyroid:4.87 adrenal gland:6.80 pancreas:4.87 breast:7.09 salivary:6.85
CAGE uterus:5.83 placenta:5.56 prostate:5.51 ovary:6.09 testis:4.36 heart:6.06 muscle:4.37 esophagus:5.13 stomach:- intestine:5.11 colon:5.10     liver/hepato:4.43    lung:6.23 bladder:6.71 kidney:5.14 pituitary:4.32 thyroid/parathyroid:4.58 adrenal gland:- pancreas:4.28 breast:5.73 salivary:5.07
RNA-seq uterus:- placenta:- prostate:5.92 ovary:6.22 testis:4.64 heart:5.09 muscle:2.84 esophagus:- stomach:- intestine:- colon:7.50     liver/hepato:3.01        lung:9.05    bladder:- kidney:5.52 pituitary:- thyroid/parathyroid:4.01 adrenal gland:5.67 pancreas:- breast:6.44 salivary:-

IDs

Refseq ID NM_003246
Gene ID 7057
Unigene ID Hs.164226
Probe set ID 201110_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000137801
GTEx ID ENSG00000137801

Orthologous Gene

Mouse[3]  NM_011580
Rat[3]  NM_011580

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed  (Pubmed ID)

101549
1350660
1550960
2010551
2335352
2341158
2430973
2435757
2478219
2522013
2544587
2745554
2918029
3030396
3084490
3402455
3461443
3571333
3997886
6338048
6438154
6693501
6777381
7521539
7775583
8288588
8408036
8463250
8550562
8751720
9045712
9169439
9304800
9328841
9334164
9419208
9459346
9478926
9657149
9840442
9867861
10397731
10398144
10487979
10698186
10749676
10772961
10900205
10922378
10982388
11023976
11067851
11094060
11134179
11358957
11606713
11773026
11801541
11820799
11882904
11920574
11964147
11980922
11986954
12054567
12147243
12147682
12220191
12358136
12391027
12443715
12444143
12450399
12477932
12482844
12530526
12553016
12598312
12609716
12643280
12658547
12676576
12679131
12718556
12759541
12782324
12824298
12878157
12902472
12909644
12927044
12947001
12964017
14555767
14557872
14559817
14561896
14568985
14583433
14683523
14718574
14963009
14991768
15007078
15014436
15034804
15037654
15095410
15113588
15140581
15166498
15217952
15258909
15292271
15342643
15347840
15356163
15456750
15503824
15522326
15583827
15634279
15634883
15665307
15696166
15700281
15730804
15792551
15799029
15817447
15820829
15833768
15855645
15890262
15907858
15908066
15927849
15945504
16006654
16037098
16100012
16141331
16147889
16148025
16150726
16166434
16263699
16270194
16335952
16344560
16388804
16465407
16478297
16495290
16502470
16618977
16650813
16684956
16732887
16740002
16835379
16882710
16951312
16962673
17106256
17175378
17198740
17289869
17363705
17374440
17378161
17413041
17416590
17487836
17507668
17572512
17596205
17620335
17638877
17706282
17709727
17879962
17917789
17996481
18021253
18035072
18057090
18089612
18096704
18178577
18208671
18222489
18226512
18275041
18319354
18321763
18336597
18384112
18413367
18425817
18499674
18515748
18555217
18641687
18653767
18661355
18674744
18675774
18676351
18688696
18700275
18712840
18726995
18757424
18788631
18853485
18855616
18855618
18940719
19056867
19239428
19250552
19271751
19322201
19351925
19383251
19396698
19414528
19422532
19435835
19447890
19485899
19509293
19531495
19542224
19570906
19581582
19584238
19661269
19687096
19698122
19706610
19710505
19715883
19721725
19732880
19738618
19747478
19762163
19805200
19826414
19906510
19913121
19958625
19959938
19998449
20016205
20056600
20103648
20182908
20203415
20204299
20300551
20346360
20360068
20372793
20449626
20452482
20453000
20458281
20467328
20470445
20485444
20492458
20494556
20498063
20546609
20625903
20628086
20655775
20673868
20705333
20876797
20923780
20927579
21107877
21139048
21142150
21148423
21152035
21157449
21161418
21193465
21217824
21296375
21307796
21317461
21343308
21378271
21402050
21420687
21437286
21474793
21501375
21518247
21526452
21531776
21565611
21659549
21762961
21822266
21845757
21883885
21899841
22011138
22014686
22024541
22028325
22028813
22035632
22037878
22136730
22194599
22198906
22207555
22231149
22238753
22247259
22268819
22308318
22311024
22318901
22383169
22403705
22583901
22592401
22672426
22750995
22796565
22971480
22982001
23030305
23085760
23119050
23145312
23202046
23315169
23350987
23380452
23463593
23528972
23614916
23660684
23664438
23667531
23677673
23749764
23933487
23995838
24053448
24314882
24371140
24615654
24618326
24877199

Gene Ontology  (GO ID)

Biological Process

GO:0000187  activation of MAPK activity
GO:0007596  blood coagulation
GO:0007155  cell adhesion
GO:0007050  cell cycle arrest
GO:0016477  cell migration
GO:0034605  cellular response to heat
GO:0002544  chronic inflammatory response
GO:0003197  endocardial cushion development
GO:0043652  engulfment of apoptotic cell
GO:0030198  extracellular matrix organization
GO:0003417  growth plate cartilage development
GO:0006955  immune response
GO:0016525  negative regulation of angiogenesis
GO:0002581  negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
GO:0043066  negative regulation of apoptosis
GO:0043537  negative regulation of blood vessel endothelial cell migration
GO:0043154  negative regulation of caspase activity
GO:0001953  negative regulation of cell-matrix adhesion
GO:0010754  negative regulation of cGMP-mediated signaling
GO:0002605  negative regulation of dendritic cell antigen processing and presentation
GO:0010596  negative regulation of endothelial cell migration
GO:0001937  negative regulation of endothelial cell proliferation
GO:0051918  negative regulation of fibrinolysis
GO:0040037  negative regulation of fibroblast growth factor receptor signaling pathway
GO:0051895  negative regulation of focal adhesion formation
GO:0032695  negative regulation of interleukin-12 production
GO:0010751  negative regulation of nitric oxide mediated signal transduction
GO:0010748  negative regulation of plasma membrane long-chain fatty acid transport
GO:0010757  negative regulation of plasminogen activation
GO:0003151  outflow tract morphogenesis
GO:0018149  peptide cross-linking
GO:0030168  platelet activation
GO:0002576  platelet degranulation
GO:0045766  positive regulation of angiogenesis
GO:0030194  positive regulation of blood coagulation
GO:0043536  positive regulation of blood vessel endothelial cell migration
GO:0030335  positive regulation of cell migration
GO:0010811  positive regulation of cell-substrate adhesion
GO:0050921  positive regulation of chemotaxis
GO:0010595  positive regulation of endothelial cell migration
GO:0010763  positive regulation of fibroblast migration
GO:0043032  positive regulation of macrophage activation
GO:0010759  positive regulation of macrophage chemotaxis
GO:0042327  positive regulation of phosphorylation
GO:0051897  positive regulation of protein kinase B signaling cascade
GO:0030511  positive regulation of transforming growth factor beta receptor signaling pathway
GO:0032914  positive regulation of transforming growth factor-beta1 production
GO:0045727  positive regulation of translation
GO:0042535  positive regulation of tumor necrosis factor biosynthetic process
GO:0051592  response to calcium ion
GO:0042493  response to drug
GO:0009749  response to glucose stimulus
GO:0001666  response to hypoxia
GO:0032026  response to magnesium ion
GO:0032570  response to progesterone stimulus
GO:0002040  sprouting angiogenesis

Cellular Component

GO:0009986  cell surface
GO:0009897  external side of plasma membrane
GO:0031012  extracellular matrix
GO:0005576  extracellular region
GO:0005615  extracellular space
GO:0070062  extracellular vesicular exosome
GO:0005577  fibrinogen complex
GO:0031091  platelet alpha granule
GO:0031093  platelet alpha granule lumen
GO:0030141  secretory granule

Molecular Function

GO:0005509  calcium ion binding
GO:0070052  collagen V binding
GO:0070051  fibrinogen binding
GO:0017134  fibroblast growth factor binding
GO:0001968  fibronectin binding
GO:0001948  glycoprotein binding
GO:0008201  heparin binding
GO:0042802  identical protein binding
GO:0005178  integrin binding
GO:0043236  laminin binding
GO:0030169  low-density lipoprotein binding
GO:0001786  phosphatidylserine binding
GO:0005515  protein binding
GO:0043394  proteoglycan binding
GO:0050431  transforming growth factor beta binding