thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian)

Synonym

c-erbA-1, NR1A1, THRA1, ERBA-ALPHA, THRA2, EAR-7.2, c-ERBA-ALPHA-2, Thyroid hormone receptor alpha, EAR-7, EAR-7.1/EAR-7.2, EAR-7.1, TR-ALPHA-1, ERBA, ERB-T-1, ERBA1, c-ERBA-1, AR7, MGC43240, MGC000261, EAR7, THRA, THRA3, C-erbA-alpha

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:20.10

cerebellum:-

brain stem:-

corpus callosum/glia:29.20

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:41.10

artery/aorta:-

vein:-

lymphnode:10.10

peripheral blood:18.20

spleen:-

thymus:12.90

bone marrow:-

adipose:-

bone:12.80

skin:9.60

GeneChip

cerebrum:7.22

cerebellum:7.10

brain stem:6.86

corpus callosum/glia:7.28

pineal gland:-

peripheral nerve:6.23

spine:7.50

retina:-

eye:-

artery/aorta:6.08

vein:5.77

lymphnode:5.48

peripheral blood:-

spleen:5.32

thymus:5.15

bone marrow:5.43

adipose:5.80

bone:-

skin:5.70

CAGE

cerebrum:5.19

cerebellum:-

brain stem:4.66

corpus callosum/glia:4.89

pineal gland:4.11

peripheral nerve:-

spine:5.01

retina:-

eye:-

artery/aorta:4.05

vein:3.36

lymphnode:2.61

peripheral blood:-

spleen:2.49

thymus:2.46

bone marrow:-

adipose:3.65

bone:-

skin:-

RNA-seq

cerebrum:2.33

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:2.40

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:2.63

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:18.20

placenta:47.40

prostate:22.50

ovary:-

testis:30.30

heart:12.80

muscle:-

esophagus:-

stomach:-

intestine:32.40

colon:8.50

liver/hepato:-

lung:14.70

bladder:-

kidney:-

pituitary:-

thyroid/parathyroid:-

adrenal gland:50.80

pancreas:-

breast:9.30

salivary:-

GeneChip

uterus:5.95

placenta:5.29

prostate:5.62

ovary:6.27

testis:5.55

heart:5.85

muscle:5.68

esophagus:5.50

stomach:5.64

intestine:5.74

colon:5.92

liver/hepato:5.37

lung:5.74

bladder:-

kidney:6.06

pituitary:6.28

thyroid/parathyroid:6.17

adrenal gland:5.77

pancreas:5.63

breast:5.85

salivary:5.57

CAGE

uterus:4.33

placenta:2.73

prostate:4.04

ovary:3.77

testis:3.30

heart:3.98

muscle:3.99

esophagus:3.47

stomach:-

intestine:3.70

colon:4.08

liver/hepato:1.90

lung:3.38

bladder:3.88

kidney:3.61

pituitary:3.56

thyroid/parathyroid:3.69

adrenal gland:-

pancreas:3.34

breast:4.34

salivary:3.63

RNA-seq

uterus:-

placenta:-

prostate:2.77

ovary:2.71

testis:1.93

heart:2.52

muscle:2.85

esophagus:-

stomach:-

intestine:-

colon:2.79

liver/hepato:0.85

lung:2.04

bladder:-

kidney:2.11

pituitary:-

thyroid/parathyroid:2.39

adrenal gland:1.91

pancreas:-

breast:2.95

salivary:-

IDs

Refseq ID	NM_199334
Gene ID	7067
Unigene ID	Hs.72451
Probe set ID	35846_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000126351
GTEx ID	ENSG00000126351

Orthologous Gene

Mouse[2]	NM_178060
Rat [0]

Chromosomal Region

17q21.1 [38,218,446 - 38,250,120]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

IPR003078	Retinoic acid receptor
IPR001723	Steroid hormone receptor
IPR001728	Thyroid hormone receptor
IPR013088	Zinc finger, NHR/GATA-type
IPR001628	Zinc finger, nuclear hormone receptor-type

Gene Ontology (GO ID)

Biological Process

GO:0001502	cartilage condensation
GO:0042994	cytoplasmic sequestering of transcription factor
GO:0030218	erythrocyte differentiation
GO:0008050	female courtship behavior
GO:0010467	gene expression
GO:0009755	hormone-mediated signaling pathway
GO:0007611	learning or memory
GO:0017055	negative regulation of RNA polymerase II transcriptional preinitiation complex assembly
GO:0045892	negative regulation of transcription, DNA-dependent
GO:0001503	ossification
GO:0045925	positive regulation of female receptivity
GO:0010831	positive regulation of myotube differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0008016	regulation of heart contraction
GO:0050994	regulation of lipid catabolic process
GO:0033032	regulation of myeloid cell apoptosis
GO:0002155	regulation of thyroid hormone mediated signaling pathway
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0009409	response to cold
GO:0030878	thyroid gland development
GO:0006366	transcription from RNA polymerase II promoter
GO:0006367	transcription initiation from RNA polymerase II promoter

Cellular Component

GO:0005829	cytosol
GO:0005654	nucleoplasm
GO:0005634	nucleus

Molecular Function

GO:0031490	chromatin DNA binding
GO:0044212	DNA regulatory region binding
GO:0005515	protein binding
GO:0032403	protein complex binding
GO:0019904	protein domain specific binding
GO:0043565	sequence-specific DNA binding
GO:0003707	steroid hormone receptor activity
GO:0002153	steroid receptor RNA activator RNA binding
GO:0017025	TATA-binding protein binding
GO:0070324	thyroid hormone binding
GO:0004887	thyroid hormone receptor activity
GO:0003700	transcription factor activity
GO:0008134	transcription factor binding
GO:0008270	zinc ion binding

thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian)

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function