toll-like receptor 4

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Synonym

hToll, TOLL, CD284 antigen, CD284, toll-like receptor 4, Toll-like receptor 4 precursor, TLR4

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:39.10 cerebellum:100.80 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:30.70 spine:- retina:- eye:35.30 artery/aorta:30 vein:66.60 lymphnode:10.10 peripheral blood:72.90 spleen:56.70 thymus:12.90 bone marrow:78.70 adipose:- bone:64 skin:19.20
GeneChip cerebrum:3.99 cerebellum:3.68 brain stem:4.04 corpus callosum/glia:4.18 pineal gland:- peripheral nerve:3.94 spine:4.51 retina:- eye:- artery/aorta:3.95 vein:3.92 lymphnode:3.80 peripheral blood:- spleen:4.34 thymus:3.51 bone marrow:5 adipose:4.22 bone:- skin:3.90
CAGE cerebrum:3.70 cerebellum:- brain stem:3.77 corpus callosum/glia:3.85 pineal gland:2.94 peripheral nerve:- spine:3.98 retina:- eye:- artery/aorta:3.80 vein:3.93 lymphnode:3.81 peripheral blood:- spleen:5.08 thymus:2.00 bone marrow:- adipose:4.60 bone:- skin:-
RNA-seq cerebrum:1.00 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:2.38 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:3.24 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:45.60 placenta:29.10 prostate:11.30 ovary:- testis:13 heart:- muscle:20.10 esophagus:- stomach:- intestine:32.40 colon:17     liver/hepato:42.20        lung:63.50    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:9.30 salivary:-
GeneChip uterus:3.81 placenta:4.79 prostate:3.71 ovary:3.63 testis:3.49 heart:4.16 muscle:3.92 esophagus:3.57 stomach:3.81 intestine:3.95 colon:4 liver/hepato:4.14 lung:3.99 bladder:- kidney:3.75 pituitary:3.62 thyroid/parathyroid:3.56 adrenal gland:3.95 pancreas:3.78 breast:3.62 salivary:3.65
CAGE uterus:3.15 placenta:3.64 prostate:3.29 ovary:3.14 testis:2.23 heart:4.02 muscle:3.16 esophagus:3.06 stomach:- intestine:2.94 colon:2.84     liver/hepato:3.25    lung:4.13 bladder:3.04 kidney:3.62 pituitary:2.74 thyroid/parathyroid:3.06 adrenal gland:- pancreas:1.98 breast:4.49 salivary:2.22
RNA-seq uterus:- placenta:- prostate:2.13 ovary:1.36 testis:0.33 heart:1.68 muscle:0.00 esophagus:- stomach:- intestine:- colon:2.65     liver/hepato:1.52        lung:2.44    bladder:- kidney:1.49 pituitary:- thyroid/parathyroid:1.55 adrenal gland:1.73 pancreas:- breast:1.76 salivary:-

IDs

Refseq ID NM_138554
Gene ID 7099
Unigene ID Hs.174312
Probe set ID 221060_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000136869
GTEx ID ENSG00000136869

Orthologous Gene

Mouse[2]  NM_021297
Rat [0]  

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed  (Pubmed ID)

9237759
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24783428

Gene Ontology  (GO ID)

Biological Process

GO:0000187  activation of MAPK activity
GO:0002322  B cell proliferation during immune response
GO:0071222  cellular response to lipopolysaccharide
GO:0071223  cellular response to lipoteichoic acid
GO:0071260  cellular response to mechanical stimulus
GO:0042742  defense response to bacterium
GO:0050829  defense response to Gram-negative bacterium
GO:0016046  detection of fungus
GO:0032497  detection of lipopolysaccharide
GO:0007249  I-kappaB kinase/NF-kappaB cascade
GO:0007252  I-kappaB phosphorylation
GO:0006955  immune response
GO:0045087  innate immune response
GO:0032609  interferon-gamma production
GO:0060729  intestinal epithelial structure maintenance
GO:0031663  lipopolysaccharide-mediated signaling pathway
GO:0042116  macrophage activation
GO:0002755  MyD88-dependent toll-like receptor signaling pathway
GO:0002756  MyD88-independent toll-like receptor signaling pathway
GO:0070373  negative regulation of ERK1 and ERK2 cascade
GO:0032689  negative regulation of interferon-gamma production
GO:0032700  negative regulation of interleukin-17 production
GO:0032707  negative regulation of interleukin-23 production
GO:0032715  negative regulation of interleukin-6 production
GO:0045671  negative regulation of osteoclast differentiation
GO:0032720  negative regulation of tumor necrosis factor production
GO:0030890  positive regulation of B cell proliferation
GO:0032722  positive regulation of chemokine production
GO:0070374  positive regulation of ERK1 and ERK2 cascade
GO:0043123  positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0050729  positive regulation of inflammatory response
GO:0032727  positive regulation of interferon-alpha production
GO:0045359  positive regulation of interferon-beta biosynthetic process
GO:0032728  positive regulation of interferon-beta production
GO:0032729  positive regulation of interferon-gamma production
GO:0032732  positive regulation of interleukin-1 production
GO:0032733  positive regulation of interleukin-10 production
GO:0045084  positive regulation of interleukin-12 biosynthetic process
GO:0032735  positive regulation of interleukin-12 production
GO:0032755  positive regulation of interleukin-6 production
GO:0045416  positive regulation of interleukin-8 biosynthetic process
GO:0032757  positive regulation of interleukin-8 production
GO:0046330  positive regulation of JNK cascade
GO:0060907  positive regulation of macrophage cytokine production
GO:0045348  positive regulation of MHC class II biosynthetic process
GO:0042346  positive regulation of NF-kappaB import into nucleus
GO:0051092  positive regulation of NF-kappaB transcription factor activity
GO:0045429  positive regulation of nitric oxide biosynthetic process
GO:0051770  positive regulation of nitric-oxide synthase biosynthetic process
GO:0070430  positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway
GO:0070434  positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
GO:0010572  positive regulation of platelet activation
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0042535  positive regulation of tumor necrosis factor biosynthetic process
GO:0032760  positive regulation of tumor necrosis factor production
GO:0002537  production of nitric oxide during acute inflammatory response
GO:0050707  regulation of cytokine secretion
GO:0032496  response to lipopolysaccharide
GO:0042088  T-helper 1 type immune response
GO:0034134  toll-like receptor 2 signaling pathway
GO:0034138  toll-like receptor 3 signaling pathway
GO:0034142  toll-like receptor 4 signaling pathway
GO:0002224  toll-like receptor signaling pathway

Cellular Component

GO:0005737  cytoplasm
GO:0010008  endosome membrane
GO:0009897  external side of plasma membrane
GO:0005887  integral to plasma membrane
GO:0046696  lipopolysaccharide receptor complex
GO:0048471  perinuclear region of cytoplasm
GO:0005886  plasma membrane

Molecular Function

GO:0001530  lipopolysaccharide binding
GO:0001875  lipopolysaccharide receptor activity
GO:0005515  protein binding
GO:0004872  receptor activity
GO:0004888  transmembrane receptor activity