tumor necrosis factor (TNF superfamily, member 2)

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Synonym

TNFSF2, tumor necrosis factor (TNF superfamily, member 2), Cachectin, Tumor necrosis factor precursor, TNF-alpha, Tumor necrosis factor ligand superfamily member 2, TNFA, TNF-a, DIF, TNF

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:1.20 cerebellum:- brain stem:- corpus callosum/glia:29.20 pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:161.80 peripheral blood:200.40 spleen:- thymus:- bone marrow:- adipose:- bone:- skin:4.80
GeneChip cerebrum:5.23 cerebellum:5.32 brain stem:5.28 corpus callosum/glia:5.29 pineal gland:- peripheral nerve:5.21 spine:5.66 retina:- eye:- artery/aorta:5.34 vein:5.46 lymphnode:5.82 peripheral blood:- spleen:5.41 thymus:5.14 bone marrow:5.68 adipose:5.44 bone:- skin:5.13
CAGE cerebrum:0.71 cerebellum:- brain stem:1.12 corpus callosum/glia:1.94 pineal gland:0.26 peripheral nerve:- spine:0.95 retina:- eye:- artery/aorta:1.91 vein:2.47 lymphnode:2.83 peripheral blood:- spleen:3.67 thymus:1.41 bone marrow:- adipose:0.63 bone:- skin:-
RNA-seq cerebrum:0.14 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:1.46 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:14.60 prostate:11.30 ovary:37.30 testis:4.30 heart:25.50 muscle:- esophagus:- stomach:- intestine:- colon:8.50     liver/hepato:-        lung:127.10    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip uterus:5.12 placenta:5.80 prostate:4.89 ovary:5.20 testis:4.83 heart:5.40 muscle:5.41 esophagus:5.20 stomach:5.29 intestine:5.18 colon:5.42 liver/hepato:5.35 lung:5.62 bladder:- kidney:5.23 pituitary:5.27 thyroid/parathyroid:5.21 adrenal gland:5.25 pancreas:5.84 breast:5.10 salivary:5.33
CAGE uterus:1.25 placenta:1.69 prostate:0.78 ovary:0.92 testis:0.31 heart:1.38 muscle:0.42 esophagus:0.94 stomach:- intestine:1.15 colon:1.25     liver/hepato:1.33    lung:2.80 bladder:0.98 kidney:1.51 pituitary:0.19 thyroid/parathyroid:0 adrenal gland:- pancreas:0.58 breast:1.16 salivary:1.67
RNA-seq uterus:- placenta:- prostate:0 ovary:0.08 testis:0.03 heart:0.01 muscle:0.17 esophagus:- stomach:- intestine:- colon:0.03     liver/hepato:0.06        lung:0.93    bladder:- kidney:0.31 pituitary:- thyroid/parathyroid:0 adrenal gland:1.45 pancreas:- breast:0.45 salivary:-

Gene Information

IDs

Refseq ID NM_000594
Gene ID 7124
Unigene ID Hs.241570
Probe set ID 207113_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000204490
ENSG00000206439
ENSG00000223952
ENSG00000228321
ENSG00000228849
ENSG00000230108
ENSG00000232810
GTEx ID ENSG00000204490
ENSG00000206439
ENSG00000223952
ENSG00000228321
ENSG00000228849
ENSG00000230108
ENSG00000232810

Orthologous Gene

Mouse[1]  NM_013693
Rat [0]  

Chromosomal Region

HSCHR6_MHC_APD  [31,555,632  -  31,557,434]
6p21.33  [31,543,344  -  31,546,113]
HSCHR6_MHC_SSTO  [31,533,287  -  31,536,056]
HSCHR6_MHC_MANN  [31,582,831  -  31,585,600]
HSCHR6_MHC_QBL  [31,533,585  -  31,536,356]
HSCHR6_MHC_MCF  [31,619,653  -  31,622,422]
HSCHR6_MHC_DBB  [31,525,488  -  31,528,257]
HSCHR6_MHC_COX  [31,530,756  -  31,533,525]

Gene Family (Interpro ID)

IPR006052  Tumor Necrosis Factor
IPR006053  Tumor necrosis factor alpha/beta/c
IPR002959  Tumour necrosis factor alpha/cachectin
IPR008983  Tumour necrosis factor-like

Link to Pubmed  (Pubmed ID)

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24557424
24560933
24567534
24574213
24582800
24611333
24611335
24613848
24625401
24625912
24654309
24654313
24668612
24720748
24726327
24771848
24786212
24839823
24897798
24933943
24933945

Gene Ontology  (GO ID)

Biological Process

GO:0006919  activation of caspase activity
GO:0000187  activation of MAPK activity
GO:0000185  activation of MAPKKK activity
GO:0006915  apoptosis
GO:0019722  calcium-mediated signaling
GO:0001775  cell activation
GO:0071230  cellular response to amino acid stimulus
GO:0071316  cellular response to nicotine
GO:0071407  cellular response to organic cyclic substance
GO:0002439  chronic inflammatory response to antigenic stimulus
GO:0050830  defense response to Gram-positive bacterium
GO:0048566  embryonic gut development
GO:0060664  epithelial cell proliferation involved in salivary gland morphogenesis
GO:0030198  extracellular matrix organization
GO:0006006  glucose metabolic process
GO:0006959  humoral immune response
GO:0006917  induction of apoptosis
GO:0008625  induction of apoptosis via death domain receptors
GO:0060555  induction of necroptosis by extracellular signals
GO:0006954  inflammatory response
GO:0007254  JNK cascade
GO:0050901  leukocyte tethering or rolling
GO:0031663  lipopolysaccharide-mediated signaling pathway
GO:0000165  MAPKKK cascade
GO:0070265  necrotic cell death
GO:0010693  negative regulation of alkaline phosphatase activity
GO:0008285  negative regulation of cell proliferation
GO:0002740  negative regulation of cytokine secretion during immune response
GO:0045599  negative regulation of fat cell differentiation
GO:0010629  negative regulation of gene expression
GO:0046325  negative regulation of glucose import
GO:0044130  negative regulation of growth of symbiont in host
GO:0032715  negative regulation of interleukin-6 production
GO:0002037  negative regulation of L-glutamate transport
GO:0050995  negative regulation of lipid catabolic process
GO:0010888  negative regulation of lipid storage
GO:0045668  negative regulation of osteoblast differentiation
GO:0043242  negative regulation of protein complex disassembly
GO:0000122  negative regulation of transcription from RNA polymerase II promoter
GO:0045892  negative regulation of transcription, DNA-dependent
GO:0045071  negative regulation of viral genome replication
GO:0009887  organ morphogenesis
GO:0030316  osteoclast differentiation
GO:0043065  positive regulation of apoptosis
GO:0060559  positive regulation of calcidiol 1-monooxygenase activity
GO:0043280  positive regulation of caspase activity
GO:0045080  positive regulation of chemokine biosynthetic process
GO:0032722  positive regulation of chemokine production
GO:0002876  positive regulation of chronic inflammatory response to antigenic stimulus
GO:0001819  positive regulation of cytokine production
GO:0050715  positive regulation of cytokine secretion
GO:0070374  positive regulation of ERK1 and ERK2 cascade
GO:0031622  positive regulation of fever
GO:0051798  positive regulation of hair follicle development
GO:0034116  positive regulation of heterotypic cell-cell adhesion
GO:0002925  positive regulation of humoral immune response mediated by circulating immunoglobulin
GO:0043123  positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0032729  positive regulation of interferon-gamma production
GO:0032755  positive regulation of interleukin-6 production
GO:0045416  positive regulation of interleukin-8 biosynthetic process
GO:0046330  positive regulation of JNK cascade
GO:0043507  positive regulation of JUN kinase activity
GO:0043406  positive regulation of MAP kinase activity
GO:0051044  positive regulation of membrane protein ectodomain proteolysis
GO:0045840  positive regulation of mitosis
GO:0010940  positive regulation of necrotic cell death
GO:0043525  positive regulation of neuron apoptosis
GO:0042346  positive regulation of NF-kappaB import into nucleus
GO:0051092  positive regulation of NF-kappaB transcription factor activity
GO:0051533  positive regulation of NFAT protein import into nucleus
GO:0045429  positive regulation of nitric oxide biosynthetic process
GO:0045672  positive regulation of osteoclast differentiation
GO:0033138  positive regulation of peptidyl-serine phosphorylation
GO:0043068  positive regulation of programmed cell death
GO:0001934  positive regulation of protein amino acid phosphorylation
GO:0031334  positive regulation of protein complex assembly
GO:0043243  positive regulation of protein complex disassembly
GO:0051897  positive regulation of protein kinase B signaling cascade
GO:0051222  positive regulation of protein transport
GO:0048661  positive regulation of smooth muscle cell proliferation
GO:0050806  positive regulation of synaptic transmission
GO:0051091  positive regulation of transcription factor activity
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0045994  positive regulation of translational initiation by iron
GO:0060557  positive regulation of vitamin D biosynthetic process
GO:0000060  protein import into nucleus, translocation
GO:0043491  protein kinase B signaling cascade
GO:0032800  receptor biosynthetic process
GO:0060693  regulation of branching involved in salivary gland morphogenesis
GO:0043122  regulation of I-kappaB kinase/NF-kappaB cascade
GO:0051023  regulation of immunoglobulin secretion
GO:0050796  regulation of insulin secretion
GO:0014823  response to activity
GO:0042493  response to drug
GO:0051384  response to glucocorticoid stimulus
GO:0001666  response to hypoxia
GO:0009612  response to mechanical stimulus
GO:0009651  response to salt stress
GO:0009615  response to virus
GO:0030730  sequestering of triglyceride
GO:0003009  skeletal muscle contraction
GO:0006927  transformed cell apoptosis
GO:0033209  tumor necrosis factor-mediated signaling pathway

Cellular Component

GO:0009986  cell surface
GO:0009897  external side of plasma membrane
GO:0005576  extracellular region
GO:0005615  extracellular space
GO:0005887  integral to plasma membrane
GO:0045121  membrane raft
GO:0001891  phagocytic cup
GO:0005886  plasma membrane
GO:0055037  recycling endosome

Molecular Function

GO:0005125  cytokine activity
GO:0044212  DNA regulatory region binding
GO:0042802  identical protein binding
GO:0002020  protease binding
GO:0005515  protein binding
GO:0005164  tumor necrosis factor receptor binding