tumor necrosis factor, alpha-induced protein 3

Synonym

TNFA1P2, MGC104522, tumor necrosis factor, alpha-induced protein 3, Tumor necrosis factor, alpha-induced protein 3, A20, Putative DNA-binding protein A20, MGC138687, TNFAIP3, OTUD7C, Zinc finger protein A20, MGC138688

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

nodata

GeneChip

cerebrum:4.76

cerebellum:4.62

brain stem:4.82

corpus callosum/glia:4.92

pineal gland:-

peripheral nerve:6.18

spine:6.34

retina:-

eye:-

artery/aorta:7.02

vein:8.13

lymphnode:8.17

peripheral blood:-

spleen:8.19

thymus:8.41

bone marrow:7.18

adipose:7.47

bone:-

skin:7.11

CAGE

cerebrum:1.38

cerebellum:-

brain stem:1.80

corpus callosum/glia:2.09

pineal gland:2.00

peripheral nerve:-

spine:2.34

retina:-

eye:-

artery/aorta:3.76

vein:4.00

lymphnode:4.31

peripheral blood:-

spleen:4.01

thymus:4.25

bone marrow:-

adipose:4.14

bone:-

skin:-

RNA-seq

cerebrum:1.28

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:4.14

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:4.21

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

nodata

GeneChip

uterus:6.46

placenta:7.49

prostate:6.73

ovary:7.36

testis:6.13

heart:6.45

muscle:5.52

esophagus:6.13

stomach:6.79

intestine:6.51

colon:6.61

liver/hepato:6.46

lung:9.33

bladder:-

kidney:5.32

pituitary:5.33

thyroid/parathyroid:6.12

adrenal gland:6.39

pancreas:5.22

breast:6.61

salivary:5.68

CAGE

uterus:2.75

placenta:3.40

prostate:3.50

ovary:4.41

testis:2.98

heart:3.28

muscle:2.92

esophagus:3.35

stomach:-

intestine:3.61

colon:3.10

liver/hepato:2.76

lung:4.58

bladder:3.94

kidney:2.72

pituitary:2.12

thyroid/parathyroid:2.13

adrenal gland:-

pancreas:2.66

breast:3.71

salivary:2.12

RNA-seq

uterus:-

placenta:-

prostate:4.03

ovary:4.88

testis:3.26

heart:1.33

muscle:2.16

esophagus:-

stomach:-

intestine:-

colon:2.75

liver/hepato:1.33

lung:5.50

bladder:-

kidney:1.96

pituitary:-

thyroid/parathyroid:2.29

adrenal gland:4.31

pancreas:-

breast:2.53

salivary:-

IDs

Refseq ID	NM_006290
Gene ID	7128
Unigene ID	-
Probe set ID	202643_s_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000118503
GTEx ID	ENSG00000118503

Orthologous Gene

Mouse[2]	NM_001166402, NM_009397
Rat[2]	NM_001166402, NM_009397

Chromosomal Region

6q23.3 [138,188,351 - 138,204,449]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

Gene Ontology (GO ID)

Biological Process

GO:0006915	apoptosis
GO:0001922	B-1 B cell homeostasis
GO:0070301	cellular response to hydrogen peroxide
GO:0071222	cellular response to lipopolysaccharide
GO:0006954	inflammatory response
GO:0045087	innate immune response
GO:0043066	negative regulation of apoptosis
GO:0050869	negative regulation of B cell activation
GO:0045779	negative regulation of bone resorption
GO:0002677	negative regulation of chronic inflammatory response
GO:0045736	negative regulation of cyclin-dependent protein kinase activity
GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB cascade
GO:0050728	negative regulation of inflammatory response
GO:0045824	negative regulation of innate immune response
GO:0032691	negative regulation of interleukin-1 beta production
GO:0032703	negative regulation of interleukin-2 production
GO:0032715	negative regulation of interleukin-6 production
GO:0032088	negative regulation of NF-kappaB transcription factor activity
GO:0070429	negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway
GO:0070433	negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
GO:0031397	negative regulation of protein ubiquitination
GO:0048662	negative regulation of smooth muscle cell proliferation
GO:0034136	negative regulation of toll-like receptor 2 signaling pathway
GO:0034140	negative regulation of toll-like receptor 3 signaling pathway
GO:0034144	negative regulation of toll-like receptor 4 signaling pathway
GO:0034148	negative regulation of toll-like receptor 5 signaling pathway
GO:0032720	negative regulation of tumor necrosis factor production
GO:0032480	negative regulation of type I interferon production
GO:0070423	nucleotide-binding oligomerization domain containing signaling pathway
GO:0045732	positive regulation of protein catabolic process
GO:0016579	protein deubiquitination
GO:0070936	protein K48-linked ubiquitination
GO:0070536	protein K63-linked deubiquitination
GO:0051259	protein oligomerization
GO:0006508	proteolysis
GO:0050691	regulation of defense response to virus by host
GO:0002634	regulation of germinal center formation
GO:0002237	response to molecule of bacterial origin
GO:0032495	response to muramyl dipeptide

Cellular Component

GO:0005813	centrosome
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005764	lysosome
GO:0005634	nucleus

Molecular Function

GO:0003677	DNA binding
GO:0019900	kinase binding
GO:0002020	protease binding
GO:0005515	protein binding
GO:0043621	protein self-association
GO:0043130	ubiquitin binding
GO:0004221	ubiquitin thiolesterase activity
GO:0004842	ubiquitin-protein ligase activity
GO:0004843	ubiquitin-specific protease activity
GO:0008270	zinc ion binding

tumor necrosis factor, alpha-induced protein 3

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function