complement component 1, s subcomponent

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Synonym

C1S, C1 esterase, complement component 1, s subcomponent, Complement C1s subcomponent precursor

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:129.20 cerebellum:75.60 brain stem:- corpus callosum/glia:58.30 pineal gland:- peripheral nerve:398.70 spine:1010.70 retina:118.60 eye:193.90 artery/aorta:60 vein:- lymphnode:10.10 peripheral blood:72.90 spleen:2117.50 thymus:1017.80 bone marrow:59 adipose:605 bone:2187.90 skin:398.40
GeneChip cerebrum:6.16 cerebellum:5.66 brain stem:6.48 corpus callosum/glia:6.58 pineal gland:- peripheral nerve:10.10 spine:8.05 retina:- eye:- artery/aorta:10.25 vein:10.64 lymphnode:9.95 peripheral blood:- spleen:9.97 thymus:8.59 bone marrow:6.61 adipose:10.58 bone:- skin:9.34
CAGE cerebrum:2.41 cerebellum:- brain stem:3.04 corpus callosum/glia:2.66 pineal gland:3.27 peripheral nerve:- spine:3.83 retina:- eye:- artery/aorta:5.22 vein:4.96 lymphnode:4.59 peripheral blood:- spleen:5.09 thymus:2.56 bone marrow:- adipose:5.47 bone:- skin:-
RNA-seq cerebrum:3.24 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:7.85 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:7.02 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:1485.50 placenta:116.60 prostate:552 ovary:521.70 testis:359.10 heart:229.90 muscle:40.20 esophagus:685.60 stomach:424.80 intestine:3239.80 colon:212     liver/hepato:897.20        lung:801.60    bladder:3014.70 kidney:124.80 pituitary:232 thyroid/parathyroid:655 adrenal gland:457.10 pancreas:71.10 breast:167.30 salivary:-
GeneChip uterus:10.14 placenta:7.30 prostate:9.13 ovary:10.71 testis:8.34 heart:9.56 muscle:7.84 esophagus:9.53 stomach:10.15 intestine:9.70 colon:9.74 liver/hepato:12.20 lung:9.98 bladder:- kidney:7.30 pituitary:6.94 thyroid/parathyroid:9.37 adrenal gland:9.62 pancreas:8.68 breast:10.12 salivary:7.87
CAGE uterus:5.21 placenta:3.66 prostate:5.65 ovary:6.23 testis:4.76 heart:5.21 muscle:4.17 esophagus:5.29 stomach:- intestine:4.39 colon:4.90     liver/hepato:7.35    lung:4.68 bladder:5.53 kidney:4.48 pituitary:3.48 thyroid/parathyroid:4.98 adrenal gland:- pancreas:4.27 breast:5.69 salivary:3.68
RNA-seq uterus:- placenta:- prostate:7.35 ovary:8.45 testis:7.33 heart:5.15 muscle:4.57 esophagus:- stomach:- intestine:- colon:7.78     liver/hepato:8.26        lung:6.78    bladder:- kidney:5.06 pituitary:- thyroid/parathyroid:6.47 adrenal gland:6.79 pancreas:- breast:5.94 salivary:-

Gene Information

IDs

Refseq ID NM_201442
Gene ID 716
Unigene ID Hs.458355
Probe set ID 208747_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000182326
GTEx ID ENSG00000182326

Orthologous Gene

Mouse[3]  NM_001097617, NM_144938, NM_173864
Rat[1]  NM_138900, NM_144938, NM_173864

Chromosomal Region

12p13.31  [7,096,351  -  7,178,336]
LRG_25  [5,001  -  15,357]

Gene Family (Interpro ID)

IPR001881  EGF-like calcium-binding
IPR000742  EGF-like, type 3
IPR001254  Peptidase S1/S6, chymotrypsin/Hap
IPR001314  Peptidase S1A, chymotrypsin
IPR009003  Serine/cysteine peptidase, trypsin-like
IPR000436  Sushi/SCR/CCP

Link to Pubmed  (Pubmed ID)

814163
1249422
1533159
1854725
2007122
2141278
2372546
2387866
2459702
2537870
2553984
2831944
2834284
3007145
3500856
3521730
3756141
6362661
6604523
7779774
9477945
9794427
9856483
9882449
9973493
10092586
10630213
10775260
10878362
11337467
11390518
11527969
12477932
12645945
12788922
14674770
14702039
15489334
16169853
16335952
16344560
18062908
19344414
19423540
20008834
20406964
20438785
20467438
20592021
21103663
22855709
23592783
23650384
23750785

Gene Ontology  (GO ID)

Biological Process

GO:0006956  complement activation
GO:0006958  complement activation, classical pathway
GO:0045087  innate immune response
GO:0006508  proteolysis

Cellular Component

GO:0005576  extracellular region

Molecular Function

GO:0005509  calcium ion binding
GO:0042802  identical protein binding
GO:0005515  protein binding
GO:0004252  serine-type endopeptidase activity