TNF receptor-associated factor 6

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Synonym

TNF receptor-associated factor 6, RING finger protein 85, RNF85, MGC:3310, Interleukin 1 signal transducer, TRAF6

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:4.70 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:30.70 spine:- retina:- eye:5.90 artery/aorta:- vein:- lymphnode:- peripheral blood:72.90 spleen:- thymus:25.80 bone marrow:- adipose:40.30 bone:- skin:19.20
GeneChip cerebrum:5.25 cerebellum:5.17 brain stem:5.08 corpus callosum/glia:5.43 pineal gland:- peripheral nerve:5.22 spine:5.35 retina:- eye:- artery/aorta:5.47 vein:5.44 lymphnode:5.43 peripheral blood:- spleen:5.69 thymus:5.73 bone marrow:5.51 adipose:5.28 bone:- skin:5.13
CAGE cerebrum:2.85 cerebellum:- brain stem:2.96 corpus callosum/glia:2.91 pineal gland:2.94 peripheral nerve:- spine:2.74 retina:- eye:- artery/aorta:2.58 vein:2.62 lymphnode:2.50 peripheral blood:- spleen:2.49 thymus:2.98 bone marrow:- adipose:2.70 bone:- skin:-
RNA-seq cerebrum:1.63 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:2.09 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:1.63 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:18.20 placenta:43.70 prostate:- ovary:37.30 testis:8.70 heart:12.80 muscle:- esophagus:- stomach:21.20 intestine:- colon:17     liver/hepato:21.10        lung:9.80    bladder:- kidney:10.40 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip uterus:5.43 placenta:5.29 prostate:5.19 ovary:5.42 testis:5.72 heart:5.58 muscle:5.47 esophagus:5.64 stomach:5.46 intestine:5.38 colon:5.51 liver/hepato:5.65 lung:5.38 bladder:- kidney:5.55 pituitary:5.23 thyroid/parathyroid:5.51 adrenal gland:5.35 pancreas:5.53 breast:5.22 salivary:5.28
CAGE uterus:2.50 placenta:2.26 prostate:2.45 ovary:2.48 testis:3.08 heart:2.54 muscle:2.37 esophagus:2.44 stomach:- intestine:2.75 colon:2.11     liver/hepato:1.90    lung:2.33 bladder:2.39 kidney:2.66 pituitary:2.58 thyroid/parathyroid:2.43 adrenal gland:- pancreas:2.41 breast:2.47 salivary:2.39
RNA-seq uterus:- placenta:- prostate:1.85 ovary:2.15 testis:2.07 heart:1.72 muscle:1.86 esophagus:- stomach:- intestine:- colon:1.50     liver/hepato:1.28        lung:1.95    bladder:- kidney:2.43 pituitary:- thyroid/parathyroid:1.97 adrenal gland:1.69 pancreas:- breast:1.74 salivary:-

IDs

Refseq ID NM_004620
Gene ID 7189
Unigene ID Hs.591983
Probe set ID 205558_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000175104
GTEx ID ENSG00000175104

Orthologous Gene

Mouse[3]  NM_009424
Rat [0]  

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed  (Pubmed ID)

8837778
8889548
9020361
9162092
9252186
9275204
9374458
9384571
9432981
9500555
9575168
9642260
9685412
9718306
9744859
9774460
9774977
9852070
9915784
9928991
9990007
10022904
10025951
10066798
10075662
10094049
10346818
10383454
10411888
10465784
10514511
10523862
10635328
10747026
10748240
10764746
10791955
10880535
10882101
10908663
10920205
10921914
11035039
11057907
11244088
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11259596
11278268
11279055
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11384837
11397809
11406619
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11728344
11751921
11809792
11847341
11882293
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12140561
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12242293
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12296995
12459498
12477932
12496252
12566447
12609980
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12787561
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12874243
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14500659
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14550571
14593105
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14633987
14661019
14665433
14702039
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14743216
14754897
14960584
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14996708
15125833
15147900
15247281
15276183
15280356
15308666
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15361868
15456887
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15489334
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15591054
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15870274
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15917247
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16024789
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16189514
16196101
16221674
16230348
16246731
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16252010
16260598
16280329
16286016
16286467
16313339
16344560
16354686
16378096
16382137
16436380
16446357
16452479
16484229
16517750
16527194
16543409
16630834
16635910
16697380
16874300
16914100
16920630
16932746
16951688
16997282
17047224
17124500
17135271
17197697
17277779
17314283
17327397
17346928
17353931
17363736
17377523
17449468
17544371
17562285
17562858
17572386
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17709375
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17878343
17905570
17942533
17948050
17982039
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18029348
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18180283
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18326498
18329614
18345001
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18474871
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18634786
18682563
18710948
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18758450
18759459
18768464
18782768
18922473
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18952891
18977328
18984593
18987746
18996842
19012753
19112497
19166926
19176615
19201866
19232515
19232518
19234489
19254290
19331827
19365808
19453261
19465916
19521662
19549727
19573080
19586614
19592251
19592497
19675569
19683680
19713527
19716405
19773279
19786094
19795416
19810754
19825828
19843958
19879840
19898481
19903815
19913121
19937093
19996094
20043910
20047764
20056178
20064081
20079715
20080758
20097753
20138174
20237496
20331378
20410276
20449947
20501938
20512936
20529958
20542134
20568250
20588308
20614026
20622874
20628086
20628368
20634198
20644648
20676093
20677014
20813000
20932475
20974803
21041452
21041727
21048031
21068390
21078302
21097508
21113135
21127049
21139048
21183682
21185369
21220427
21312055
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21435586
21454471
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21629263
21703539
21725320
21805090
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21816939
21832049
21886773
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21903422
21906983
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21911421
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21940676
21980489
21988832
22011580
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22095711
22140520
22231568
22303480
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22326918
22447928
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22513239
22589256
22590573
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22643835
22644879
22656185
22719861
22736025
22851693
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22863753
22886393
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23013936
23017601
23018911
23042151
23055197
23105109
23172226
23185365
23244239
23264041
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23381138
23399697
23431243
23437331
23478027
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23575687
23608757
23685241
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23722539
23774506
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23794111
23799152
23818111
23885119
23909487
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23962979
23986494
24026882
24061540
24084649
24103590
24128730
24270048
24301457
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24321786
24337384
24360988
24366338
24434549
24442433
24456201
24464131
24578159
24586659
24610907
24735611
24777252
24816145

Gene Ontology  (GO ID)

Biological Process

GO:0000187  activation of MAPK activity
GO:0007250  activation of NF-kappaB-inducing kinase activity
GO:0032147  activation of protein kinase activity
GO:0019886  antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0045453  bone resorption
GO:0048468  cell development
GO:0007249  I-kappaB kinase/NF-kappaB cascade
GO:0045087  innate immune response
GO:0070498  interleukin-1-mediated signaling pathway
GO:0007254  JNK cascade
GO:0031293  membrane protein intracellular domain proteolysis
GO:0002755  MyD88-dependent toll-like receptor signaling pathway
GO:0002756  MyD88-independent toll-like receptor signaling pathway
GO:0043011  myeloid dendritic cell differentiation
GO:0043066  negative regulation of apoptosis
GO:0000122  negative regulation of transcription from RNA polymerase II promoter
GO:0045892  negative regulation of transcription, DNA-dependent
GO:0048011  nerve growth factor receptor signaling pathway
GO:0001843  neural tube closure
GO:0070423  nucleotide-binding oligomerization domain containing signaling pathway
GO:0042475  odontogenesis of dentine-containing tooth
GO:0001503  ossification
GO:0030316  osteoclast differentiation
GO:0043065  positive regulation of apoptosis
GO:0043123  positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0045084  positive regulation of interleukin-12 biosynthetic process
GO:0032743  positive regulation of interleukin-2 production
GO:0045410  positive regulation of interleukin-6 biosynthetic process
GO:0043507  positive regulation of JUN kinase activity
GO:0031666  positive regulation of lipopolysaccharide-mediated signaling pathway
GO:0051092  positive regulation of NF-kappaB transcription factor activity
GO:0045672  positive regulation of osteoclast differentiation
GO:0031398  positive regulation of protein ubiquitination
GO:0048661  positive regulation of smooth muscle cell proliferation
GO:0050870  positive regulation of T cell activation
GO:0002726  positive regulation of T cell cytokine production
GO:0042102  positive regulation of T cell proliferation
GO:0051091  positive regulation of transcription factor activity
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0051865  protein autoubiquitination
GO:0006461  protein complex assembly
GO:0070534  protein K63-linked ubiquitination
GO:0000209  protein polyubiquitination
GO:0051023  regulation of immunoglobulin secretion
GO:0070555  response to interleukin-1
GO:0051403  stress-activated MAPK cascade
GO:0050852  T cell receptor signaling pathway
GO:0042088  T-helper 1 type immune response
GO:0034166  toll-like receptor 10 signaling pathway
GO:0034134  toll-like receptor 2 signaling pathway
GO:0034138  toll-like receptor 3 signaling pathway
GO:0034142  toll-like receptor 4 signaling pathway
GO:0034146  toll-like receptor 5 signaling pathway
GO:0034162  toll-like receptor 9 signaling pathway
GO:0002224  toll-like receptor signaling pathway

Cellular Component

GO:0005938  cell cortex
GO:0005737  cytoplasm
GO:0005829  cytosol
GO:0010008  endosome membrane
GO:0009898  internal side of plasma membrane
GO:0005811  lipid particle
GO:0031965  nuclear membrane
GO:0005730  nucleolus
GO:0005634  nucleus
GO:0048471  perinuclear region of cytoplasm
GO:0005886  plasma membrane

Molecular Function

GO:0042826  histone deacetylase binding
GO:0031435  mitogen-activated protein kinase kinase kinase binding
GO:0005515  protein binding
GO:0043422  protein kinase B binding
GO:0019901  protein kinase binding
GO:0047485  protein N-terminus binding
GO:0004871  signal transducer activity
GO:0031996  thioesterase binding
GO:0031625  ubiquitin protein ligase binding
GO:0004842  ubiquitin-protein ligase activity
GO:0008270  zinc ion binding