TNF receptor-associated factor 6

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Synonym

TNF receptor-associated factor 6, RING finger protein 85, RNF85, MGC:3310, Interleukin 1 signal transducer, TRAF6

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:4.70

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:30.70

spine:-

retina:-

eye:5.90

artery/aorta:-

vein:-

lymphnode:-

peripheral blood:72.90

spleen:-

thymus:25.80

bone marrow:-

adipose:40.30

bone:-

skin:19.20

GeneChip

cerebrum:5.25

cerebellum:5.17

brain stem:5.08

corpus callosum/glia:5.43

pineal gland:-

peripheral nerve:5.22

spine:5.35

retina:-

eye:-

artery/aorta:5.47

vein:5.44

lymphnode:5.43

peripheral blood:-

spleen:5.69

thymus:5.73

bone marrow:5.51

adipose:5.28

bone:-

skin:5.13

CAGE

cerebrum:2.85

cerebellum:-

brain stem:2.96

corpus callosum/glia:2.91

pineal gland:2.94

peripheral nerve:-

spine:2.74

retina:-

eye:-

artery/aorta:2.58

vein:2.62

lymphnode:2.50

peripheral blood:-

spleen:2.49

thymus:2.98

bone marrow:-

adipose:2.70

bone:-

skin:-

RNA-seq

cerebrum:0.00

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:0.00

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:0.00

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:18.20

placenta:43.70

prostate:-

ovary:37.30

testis:8.70

heart:12.80

muscle:-

esophagus:-

stomach:21.20

intestine:-

colon:17

liver/hepato:21.10

lung:9.80

bladder:-

kidney:10.40

pituitary:-

thyroid/parathyroid:-

adrenal gland:-

pancreas:-

breast:-

salivary:-

GeneChip

uterus:5.43

placenta:5.29

prostate:5.19

ovary:5.42

testis:5.72

heart:5.58

muscle:5.47

esophagus:5.64

stomach:5.46

intestine:5.38

colon:5.51

liver/hepato:5.65

lung:5.38

bladder:-

kidney:5.55

pituitary:5.23

thyroid/parathyroid:5.51

adrenal gland:5.35

pancreas:5.53

breast:5.22

salivary:5.28

CAGE

uterus:2.50

placenta:2.26

prostate:2.45

ovary:2.48

testis:3.08

heart:2.54

muscle:2.37

esophagus:2.44

stomach:-

intestine:2.75

colon:2.11

liver/hepato:1.90

lung:2.33

bladder:2.39

kidney:2.66

pituitary:2.58

thyroid/parathyroid:2.43

adrenal gland:-

pancreas:2.41

breast:2.47

salivary:2.39

RNA-seq

uterus:-

placenta:-

prostate:0.00

ovary:0.00

testis:0.06

heart:0.00

muscle:0.00

esophagus:-

stomach:-

intestine:-

colon:0.00

liver/hepato:0.00

lung:0.00

bladder:-

kidney:0.00

pituitary:-

thyroid/parathyroid:0.00

adrenal gland:0.28

pancreas:-

breast:0.00

salivary:-

IDs

Refseq ID	NM_145803
Gene ID	7189
Unigene ID	Hs.591983
Probe set ID	205558_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000175104
GTEx ID	ENSG00000175104

Orthologous Gene

Mouse[3]	NM_009424
Rat [0]

Chromosomal Region

11p12 [36,508,577 - 36,531,822]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

IPR002083	MATH
IPR012227	TNF receptor-associated factor TRAF
IPR008974	TRAF-like

Gene Ontology (GO ID)

Biological Process

GO:0000187	activation of MAPK activity
GO:0007250	activation of NF-kappaB-inducing kinase activity
GO:0032147	activation of protein kinase activity
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0045453	bone resorption
GO:0048468	cell development
GO:0007249	I-kappaB kinase/NF-kappaB cascade
GO:0045087	innate immune response
GO:0070498	interleukin-1-mediated signaling pathway
GO:0007254	JNK cascade
GO:0031293	membrane protein intracellular domain proteolysis
GO:0002755	MyD88-dependent toll-like receptor signaling pathway
GO:0002756	MyD88-independent toll-like receptor signaling pathway
GO:0043011	myeloid dendritic cell differentiation
GO:0043066	negative regulation of apoptosis
GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0045892	negative regulation of transcription, DNA-dependent
GO:0048011	nerve growth factor receptor signaling pathway
GO:0001843	neural tube closure
GO:0070423	nucleotide-binding oligomerization domain containing signaling pathway
GO:0042475	odontogenesis of dentine-containing tooth
GO:0001503	ossification
GO:0030316	osteoclast differentiation
GO:0043065	positive regulation of apoptosis
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0045084	positive regulation of interleukin-12 biosynthetic process
GO:0032743	positive regulation of interleukin-2 production
GO:0045410	positive regulation of interleukin-6 biosynthetic process
GO:0043507	positive regulation of JUN kinase activity
GO:0031666	positive regulation of lipopolysaccharide-mediated signaling pathway
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0045672	positive regulation of osteoclast differentiation
GO:0031398	positive regulation of protein ubiquitination
GO:0048661	positive regulation of smooth muscle cell proliferation
GO:0050870	positive regulation of T cell activation
GO:0002726	positive regulation of T cell cytokine production
GO:0042102	positive regulation of T cell proliferation
GO:0051091	positive regulation of transcription factor activity
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051865	protein autoubiquitination
GO:0006461	protein complex assembly
GO:0070534	protein K63-linked ubiquitination
GO:0000209	protein polyubiquitination
GO:0051023	regulation of immunoglobulin secretion
GO:0070555	response to interleukin-1
GO:0051403	stress-activated MAPK cascade
GO:0050852	T cell receptor signaling pathway
GO:0042088	T-helper 1 type immune response
GO:0034166	toll-like receptor 10 signaling pathway
GO:0034134	toll-like receptor 2 signaling pathway
GO:0034138	toll-like receptor 3 signaling pathway
GO:0034142	toll-like receptor 4 signaling pathway
GO:0034146	toll-like receptor 5 signaling pathway
GO:0034162	toll-like receptor 9 signaling pathway
GO:0002224	toll-like receptor signaling pathway

Cellular Component

GO:0005938	cell cortex
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0010008	endosome membrane
GO:0009898	internal side of plasma membrane
GO:0005811	lipid particle
GO:0031965	nuclear membrane
GO:0005730	nucleolus
GO:0005634	nucleus
GO:0048471	perinuclear region of cytoplasm
GO:0005886	plasma membrane

Molecular Function

GO:0042826	histone deacetylase binding
GO:0031435	mitogen-activated protein kinase kinase kinase binding
GO:0005515	protein binding
GO:0043422	protein kinase B binding
GO:0019901	protein kinase binding
GO:0047485	protein N-terminus binding
GO:0004871	signal transducer activity
GO:0031996	thioesterase binding
GO:0031625	ubiquitin protein ligase binding
GO:0004842	ubiquitin-protein ligase activity
GO:0008270	zinc ion binding

TNF receptor-associated factor 6

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function