complement component 4 binding protein, alpha

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Synonym

Proline-rich protein, C4BP, complement component 4 binding protein, alpha, C4BPA, C4b-binding protein alpha chain precursor, C4bp

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:8.30 cerebellum:- brain stem:- corpus callosum/glia:29.20 pineal gland:- peripheral nerve:- spine:- retina:- eye:11.80 artery/aorta:- vein:- lymphnode:50.60 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:25.60 skin:9.60
GeneChip cerebrum:6 cerebellum:6.27 brain stem:5.95 corpus callosum/glia:6.11 pineal gland:- peripheral nerve:6.10 spine:6.13 retina:- eye:- artery/aorta:6.19 vein:6.08 lymphnode:6.25 peripheral blood:- spleen:6.08 thymus:6.16 bone marrow:6.56 adipose:6.11 bone:- skin:6.18
CAGE cerebrum:0.12 cerebellum:- brain stem:0 corpus callosum/glia:0 pineal gland:0 peripheral nerve:- spine:0 retina:- eye:- artery/aorta:1.16 vein:0 lymphnode:0.19 peripheral blood:- spleen:0.25 thymus:0 bone marrow:- adipose:0 bone:- skin:-
RNA-seq cerebrum:0.03 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0.03 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.01 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:36.50 placenta:- prostate:- ovary:- testis:8.70 heart:- muscle:- esophagus:- stomach:21.20 intestine:- colon:-     liver/hepato:358.90        lung:97.80    bladder:376.80 kidney:10.40 pituitary:- thyroid/parathyroid:- adrenal gland:50.80 pancreas:8.90 breast:55.80 salivary:-
GeneChip uterus:6.54 placenta:6.19 prostate:5.93 ovary:6.63 testis:6.11 heart:5.93 muscle:6.22 esophagus:5.97 stomach:6.16 intestine:6.73 colon:6.10 liver/hepato:11.87 lung:9.06 bladder:- kidney:6.09 pituitary:6.28 thyroid/parathyroid:6.11 adrenal gland:6.04 pancreas:6.36 breast:6.40 salivary:5.89
CAGE uterus:1.30 placenta:0.59 prostate:0.08 ovary:1.11 testis:0.21 heart:0.03 muscle:0 esophagus:0 stomach:- intestine:0.21 colon:0.38     liver/hepato:7.75    lung:5.36 bladder:0.33 kidney:0.62 pituitary:0 thyroid/parathyroid:0.23 adrenal gland:- pancreas:2.18 breast:0.55 salivary:0
RNA-seq uterus:- placenta:- prostate:0.02 ovary:1.46 testis:1.09 heart:0.05 muscle:0.00 esophagus:- stomach:- intestine:- colon:0     liver/hepato:9.49        lung:6.35    bladder:- kidney:0.06 pituitary:- thyroid/parathyroid:0.09 adrenal gland:0.37 pancreas:- breast:0.23 salivary:-

Gene Information

IDs

Refseq ID NM_000715
Gene ID 722
Unigene ID Hs.1012
Probe set ID 205654_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000123838
GTEx ID ENSG00000123838

Orthologous Gene

Mouse[1]  NM_007576
Rat[1]  NM_182815

Chromosomal Region

1q32.2  [207,277,607  -  207,318,317]

Gene Family (Interpro ID)

IPR000436  Sushi/SCR/CCP

Link to Pubmed  (Pubmed ID)

1534488
1833851
1989602
2237642
2352933
2590215
3017751
3378624
3840370
4033666
6222381
7592941
7772049
7806286
8406448
9089100
9628846
10383431
10744423
11441101
11705989
12100475
12135356
12477932
12893820
14607961
14718574
15179322
15188402
15489334
16330538
16335952
16819837
17225862
17548110
17579075
18029348
18406463
18424762
18556068
18715646
18842294
19076829
19155499
19344414
19417080
19423540
19494311
20022381
20059470
20212171
20237496
20406964
20438785
20532227
21262398
21659506
21915248
21988832
22333221
22732096
22925928
23274142
23390292
23508668
23750785
24760758
24779215

Gene Ontology  (GO ID)

Biological Process

GO:0007339  binding of sperm to zona pellucida
GO:0006958  complement activation, classical pathway
GO:0045087  innate immune response
GO:0030449  regulation of complement activation

Cellular Component

GO:0043159  acrosomal matrix
GO:0005737  cytoplasm
GO:0005576  extracellular region
GO:0005886  plasma membrane

Molecular Function

GO:0005515  protein binding