complement component 5

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Synonym

MGC142298, CPAMD4, Complement C5 precursor, C5, complement component 5

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:2.40

cerebellum:-

brain stem:-

corpus callosum/glia:29.20

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:11.80

artery/aorta:-

vein:-

lymphnode:20.20

peripheral blood:-

spleen:18.90

thymus:-

bone marrow:19.70

adipose:-

bone:12.80

skin:-

GeneChip

cerebrum:4.63

cerebellum:4.34

brain stem:4.79

corpus callosum/glia:4.95

pineal gland:-

peripheral nerve:4.61

spine:4.95

retina:-

eye:-

artery/aorta:4.56

vein:4.67

lymphnode:4.37

peripheral blood:-

spleen:3.95

thymus:3.81

bone marrow:4.39

adipose:4.52

bone:-

skin:4.28

CAGE

cerebrum:1.17

cerebellum:-

brain stem:1.27

corpus callosum/glia:1.19

pineal gland:0.79

peripheral nerve:-

spine:1.61

retina:-

eye:-

artery/aorta:1.68

vein:1.49

lymphnode:0.99

peripheral blood:-

spleen:1.32

thymus:0.64

bone marrow:-

adipose:1.63

bone:-

skin:-

RNA-seq

cerebrum:1.26

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:0.97

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:0.64

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:18.20

placenta:3.60

prostate:45.10

ovary:-

testis:17.30

heart:-

muscle:-

esophagus:-

stomach:-

intestine:-

colon:17

liver/hepato:348.30

lung:34.20

bladder:-

kidney:83.20

pituitary:-

thyroid/parathyroid:-

adrenal gland:-

pancreas:-

breast:9.30

salivary:-

GeneChip

uterus:4.60

placenta:4.20

prostate:4.61

ovary:4.48

testis:4.06

heart:4.48

muscle:4.32

esophagus:4.04

stomach:4.81

intestine:4.75

colon:4.44

liver/hepato:10.13

lung:4.60

bladder:-

kidney:4.89

pituitary:4.61

thyroid/parathyroid:4.10

adrenal gland:4.26

pancreas:6.29

breast:4.43

salivary:4.41

CAGE

uterus:1.38

placenta:0.37

prostate:1.64

ovary:1.11

testis:1.19

heart:0.90

muscle:0.84

esophagus:1.36

stomach:-

intestine:2.55

colon:1.52

liver/hepato:6.82

lung:2.52

bladder:1.32

kidney:1.63

pituitary:1.15

thyroid/parathyroid:0.45

adrenal gland:-

pancreas:3.13

breast:1.36

salivary:0.36

RNA-seq

uterus:-

placenta:-

prostate:1.32

ovary:1.51

testis:1.34

heart:0.32

muscle:0.12

esophagus:-

stomach:-

intestine:-

colon:1.14

liver/hepato:7.30

lung:1.38

bladder:-

kidney:1.16

pituitary:-

thyroid/parathyroid:0.94

adrenal gland:1.02

pancreas:-

breast:0.79

salivary:-

IDs

Refseq ID	NM_001735
Gene ID	727
Unigene ID	Hs.494997
Probe set ID	205500_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000106804
GTEx ID	ENSG00000106804

Orthologous Gene

Mouse[1]	NM_010406
Rat[1]	NM_010406

Chromosomal Region

9q33.2 [123,714,616 - 123,837,452]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

LRG_28 [5,001 - 102,942]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

IPR018081	Anaphylatoxin
IPR000020	Anaphylatoxin/fibulin
IPR001840	Complement C3a/C4a/C5a anaphylatoxin
IPR001134	Netrin domain
IPR018933	Netrin module, non-TIMP type
IPR008993	TIMP-like, OB-fold

Gene Ontology (GO ID)

Biological Process

GO:0000187	activation of MAPK activity
GO:0007166	cell surface receptor linked signal transduction
GO:0006874	cellular calcium ion homeostasis
GO:0006935	chemotaxis
GO:0006956	complement activation
GO:0006957	complement activation, alternative pathway
GO:0006958	complement activation, classical pathway
GO:0019835	cytolysis
GO:0007186	G-protein coupled receptor protein signaling pathway
GO:0042593	glucose homeostasis
GO:0001701	in utero embryonic development
GO:0006917	induction of apoptosis
GO:0006954	inflammatory response
GO:0045087	innate immune response
GO:0002523	leukocyte migration during inflammatory response
GO:0033602	negative regulation of dopamine secretion
GO:0010760	negative regulation of macrophage chemotaxis
GO:0010700	negative regulation of norepinephrine secretion
GO:0045766	positive regulation of angiogenesis
GO:0090197	positive regulation of chemokine secretion
GO:0050921	positive regulation of chemotaxis
GO:0010575	positive regulation vascular endothelial growth factor production
GO:0030449	regulation of complement activation
GO:0006950	response to stress

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005579	membrane attack complex

Molecular Function

GO:0031714	C5a anaphylatoxin chemotactic receptor binding
GO:0008009	chemokine activity
GO:0004866	endopeptidase inhibitor activity
GO:0005102	receptor binding

complement component 5

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function