complement component 6

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Synonym

C6, complement component 6, Complement component C6 precursor

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:3.60 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:12.90 bone marrow:- adipose:40.30 bone:12.80 skin:-
GeneChip cerebrum:4.64 cerebellum:4.53 brain stem:4.71 corpus callosum/glia:4.83 pineal gland:- peripheral nerve:4.54 spine:4.55 retina:- eye:- artery/aorta:5.95 vein:5.68 lymphnode:4.78 peripheral blood:- spleen:4.29 thymus:4.85 bone marrow:4.70 adipose:6.79 bone:- skin:5.26
CAGE cerebrum:0.11 cerebellum:- brain stem:0 corpus callosum/glia:0.82 pineal gland:0 peripheral nerve:- spine:0.09 retina:- eye:- artery/aorta:1.03 vein:2.70 lymphnode:0.77 peripheral blood:- spleen:0 thymus:0.18 bone marrow:- adipose:2.42 bone:- skin:-
RNA-seq cerebrum:0.00 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0.00 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.00 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:9.10 placenta:- prostate:- ovary:37.30 testis:34.60 heart:25.50 muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:274.40        lung:58.70    bladder:125.60 kidney:31.20 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:35.60 breast:- salivary:-
GeneChip uterus:4.53 placenta:4.13 prostate:4.45 ovary:6.78 testis:5.27 heart:6.97 muscle:5.49 esophagus:4.99 stomach:4.95 intestine:6.03 colon:4.59 liver/hepato:10.35 lung:4.95 bladder:- kidney:4.86 pituitary:4.64 thyroid/parathyroid:4.78 adrenal gland:5.07 pancreas:8.01 breast:4.85 salivary:4.86
CAGE uterus:0.86 placenta:0.08 prostate:0.81 ovary:2.58 testis:1.65 heart:3.50 muscle:0.13 esophagus:1.20 stomach:- intestine:1.29 colon:1.27     liver/hepato:6.26    lung:1.48 bladder:0.78 kidney:2.92 pituitary:0.38 thyroid/parathyroid:0.79 adrenal gland:- pancreas:3.52 breast:0 salivary:0.62
RNA-seq uterus:- placenta:- prostate:0.00 ovary:3.08 testis:0.49 heart:0.20 muscle:0.00 esophagus:- stomach:- intestine:- colon:0.00     liver/hepato:0.00        lung:0.00    bladder:- kidney:0.00 pituitary:- thyroid/parathyroid:0.00 adrenal gland:0.32 pancreas:- breast:0.00 salivary:-

Gene Information

IDs

Refseq ID NM_001115131
Gene ID 729
Unigene ID Hs.481992
Probe set ID 210168_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000039537
GTEx ID ENSG00000039537

Orthologous Gene

Mouse[1]  NM_016704
Rat[1]  NM_176074

Chromosomal Region

5p13.1  [41,142,336  -  41,261,540]
LRG_29  [52,874  -  124,205]

Gene Family (Interpro ID)

IPR020864  Membrane attack complex component/perforin (MACPF) domain
IPR000436  Sushi/SCR/CCP
IPR000884  Thrombospondin, type 1 repeat

Link to Pubmed  (Pubmed ID)

1387399
1672663
2468158
2789218
2808363
3052276
3192535
3764345
8101442
8364540
8512929
8805625
9366265
9472666
9856498
10551839
12477932
14757862
15489334
15845028
16169070
16335952
16344560
17257682
17474147
18842294
19162005
19344414
19423540
19665237
19864026
19913121
20237496
20406964
20438785
20459687
20628086
21704099
21988832
22267737
22288589
22500023
23149075
23750785

Gene Ontology  (GO ID)

Biological Process

GO:0006956  complement activation
GO:0006958  complement activation, classical pathway
GO:0019835  cytolysis
GO:0001701  in utero embryonic development
GO:0045087  innate immune response
GO:0001970  positive regulation of activation of membrane attack complex
GO:0045766  positive regulation of angiogenesis
GO:0030449  regulation of complement activation

Cellular Component

GO:0005576  extracellular region
GO:0005579  membrane attack complex

Molecular Function

GO:0005515  protein binding