tumor necrosis factor (ligand) superfamily, member 4

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Synonym

Glycoprotein Gp34, TNFSF4, CD252 antigen, CD252, TXGP1, CD134L, gp34, Tumor necrosis factor ligand superfamily member 4, OX4OL, TAX transcriptionally-activated glycoprotein 1, GP34, OX-40L, OX40 ligand, OX40L

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:3.60 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:11.80 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:12.90 bone marrow:- adipose:- bone:- skin:9.60
GeneChip cerebrum:4.61 cerebellum:4.69 brain stem:4.60 corpus callosum/glia:4.64 pineal gland:- peripheral nerve:4.60 spine:4.75 retina:- eye:- artery/aorta:4.50 vein:4.57 lymphnode:4.64 peripheral blood:- spleen:4.92 thymus:5.39 bone marrow:4.77 adipose:4.65 bone:- skin:4.38
CAGE cerebrum:0.15 cerebellum:- brain stem:0 corpus callosum/glia:0.07 pineal gland:0 peripheral nerve:- spine:0.09 retina:- eye:- artery/aorta:0 vein:0.59 lymphnode:0.95 peripheral blood:- spleen:1.18 thymus:1.10 bone marrow:- adipose:0.26 bone:- skin:-
RNA-seq cerebrum:0.65 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0.99 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.34 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip uterus:4.61 placenta:4.80 prostate:5.19 ovary:4.61 testis:5.79 heart:4.43 muscle:4.53 esophagus:4.36 stomach:4.56 intestine:4.53 colon:4.32 liver/hepato:4.40 lung:4.49 bladder:- kidney:4.50 pituitary:4.98 thyroid/parathyroid:4.37 adrenal gland:4.85 pancreas:4.46 breast:4.39 salivary:4.34
CAGE uterus:0.09 placenta:0.08 prostate:0.27 ovary:0.47 testis:1.52 heart:0.11 muscle:0 esophagus:0.26 stomach:- intestine:0.33 colon:0.04     liver/hepato:0    lung:0.45 bladder:0.26 kidney:0 pituitary:0 thyroid/parathyroid:0 adrenal gland:- pancreas:0 breast:0.55 salivary:0
RNA-seq uterus:- placenta:- prostate:1.27 ovary:1.13 testis:1.71 heart:0.36 muscle:0.20 esophagus:- stomach:- intestine:- colon:0.38     liver/hepato:0.16        lung:0.92    bladder:- kidney:0.74 pituitary:- thyroid/parathyroid:0.23 adrenal gland:0.45 pancreas:- breast:0.56 salivary:-

Gene Information

IDs

Refseq ID NM_003326
Gene ID 7292
Unigene ID Hs.181097
Probe set ID 207426_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000117586
GTEx ID ENSG00000117586

Orthologous Gene

Mouse[1]  NM_009452
Rat [0]  

Chromosomal Region

1q25.1  [173,152,873  -  173,176,452]

Gene Family (Interpro ID)

IPR006052  Tumor Necrosis Factor
IPR008983  Tumour necrosis factor-like

Link to Pubmed  (Pubmed ID)

1996093
7913952
8076595
8642328
9108415
9378971
9418902
9603911
9862675
10358148
11069062
11197696
11346458
12134113
12477932
12624783
12798307
15034038
15100674
15218969
15356117
15470070
15750594
16272289
16275760
16710414
16905106
16924108
17016617
17166734
17185358
17584577
17666213
18059267
18060034
18174230
18356244
18397322
18398332
18501882
18674525
18718855
18832690
18987746
18998106
19029446
19029970
19083191
19092840
19357697
19494280
19573080
19578796
19663699
19773279
19778912
19838193
19913121
19951374
20012871
20139223
20190752
20237496
20307208
20331378
20568250
20628086
20677014
20844189
20848568
20861858
20881011
20962850
21068098
21102463
21143648
21187296
21239696
21397857
21402531
21441570
21445270
21476935
21781408
21820713
21986129
22156349
22422496
22646697
22760717
22820624
22847298
22850862
22870213
23184501
23216302
23273568
23469620
23589118
23622253
23635951
23740937
23874208
23936824
23948416
23953582
24679586

Gene Ontology  (GO ID)

Biological Process

GO:0002526  acute inflammatory response
GO:0071222  cellular response to lipopolysaccharide
GO:0071380  cellular response to prostaglandin E stimulus
GO:0008203  cholesterol metabolic process
GO:0002215  defense response to nematode
GO:0050710  negative regulation of cytokine secretion
GO:0032689  negative regulation of interferon-gamma production
GO:0032700  negative regulation of interleukin-17 production
GO:0045590  negative regulation of regulatory T cell differentiation
GO:0045626  negative regulation of T-helper 1 cell differentiation
GO:0043433  negative regulation of transcription factor activity
GO:0045892  negative regulation of transcription, DNA-dependent
GO:0042104  positive regulation of activated T cell proliferation
GO:0046641  positive regulation of alpha-beta T cell proliferation
GO:0050871  positive regulation of B cell activation
GO:0043372  positive regulation of CD4-positive, alpha beta T cell differentiation
GO:0008284  positive regulation of cell proliferation
GO:0002891  positive regulation of immunoglobulin mediated immune response
GO:0051024  positive regulation of immunoglobulin secretion
GO:0050729  positive regulation of inflammatory response
GO:0032729  positive regulation of interferon-gamma production
GO:0032733  positive regulation of interleukin-10 production
GO:0032735  positive regulation of interleukin-12 production
GO:0032736  positive regulation of interleukin-13 production
GO:0032743  positive regulation of interleukin-2 production
GO:0032753  positive regulation of interleukin-4 production
GO:0032755  positive regulation of interleukin-6 production
GO:0043382  positive regulation of memory T cell differentiation
GO:0002726  positive regulation of T cell cytokine production
GO:0045630  positive regulation of T-helper 2 cell differentiation
GO:0002830  positive regulation of T-helper 2 type immune response
GO:0002819  regulation of adaptive immune response
GO:0050727  regulation of inflammatory response
GO:0042221  response to chemical stimulus
GO:0009615  response to virus
GO:0007165  signal transduction
GO:0042098  T cell proliferation

Cellular Component

GO:0009986  cell surface
GO:0005615  extracellular space
GO:0005887  integral to plasma membrane

Molecular Function

GO:0005125  cytokine activity
GO:0005102  receptor binding
GO:0005164  tumor necrosis factor receptor binding
GO:0032813  tumor necrosis factor receptor superfamily binding