ubiquitin-conjugating enzyme E2 variant 1

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Synonym

UEV1A, CROC1, UBE2V, UEV1, CIR1, TRAF6-regulated IKK activator 1 beta Uev1A, ubiquitin-conjugating enzyme E2 variant 1, Ubiquitin-conjugating enzyme variant Kua, P/OKcl.19, UEV-1, Ubiquitin-conjugating enzyme E2 variant 1, CROC-1

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:206.20 cerebellum:188.90 brain stem:- corpus callosum/glia:262.50 pineal gland:- peripheral nerve:92 spine:336.90 retina:118.60 eye:205.70 artery/aorta:119.90 vein:133.30 lymphnode:151.70 peripheral blood:364.40 spleen:151.30 thymus:257.70 bone marrow:118.10 adipose:201.70 bone:255.90 skin:355.20
GeneChip cerebrum:6.30 cerebellum:5.56 brain stem:6.46 corpus callosum/glia:5.76 pineal gland:- peripheral nerve:6.47 spine:5.96 retina:- eye:- artery/aorta:6.11 vein:6.67 lymphnode:6.72 peripheral blood:- spleen:6.93 thymus:6.74 bone marrow:7.15 adipose:6.71 bone:- skin:6.47
CAGE cerebrum:4.45 cerebellum:- brain stem:4.19 corpus callosum/glia:4.33 pineal gland:3.87 peripheral nerve:- spine:4.32 retina:- eye:- artery/aorta:3.88 vein:3.83 lymphnode:4.16 peripheral blood:- spleen:4.40 thymus:4.12 bone marrow:- adipose:4.33 bone:- skin:-
RNA-seq cerebrum:0.55 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0.85 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.77 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:309.80 placenta:233.20 prostate:180.20 ovary:372.60 testis:173.10 heart:204.30 muscle:40.20 esophagus:685.60 stomach:382.40 intestine:291.60 colon:449.40     liver/hepato:116.10        lung:122.20    bladder:376.80 kidney:72.80 pituitary:- thyroid/parathyroid:327.50 adrenal gland:101.60 pancreas:71.10 breast:1161.60 salivary:-
GeneChip uterus:6.72 placenta:7.39 prostate:6.69 ovary:6.52 testis:7 heart:6.88 muscle:6.37 esophagus:7.47 stomach:6.78 intestine:6.88 colon:6.72 liver/hepato:6.60 lung:6.64 bladder:- kidney:6.49 pituitary:5.72 thyroid/parathyroid:6.11 adrenal gland:6.74 pancreas:6.87 breast:6.45 salivary:6.68
CAGE uterus:4.13 placenta:4.56 prostate:4.09 ovary:4.43 testis:4.17 heart:3.98 muscle:4.27 esophagus:4.47 stomach:- intestine:4.44 colon:4.06     liver/hepato:4.76    lung:4.18 bladder:4.72 kidney:4.37 pituitary:3.95 thyroid/parathyroid:4.02 adrenal gland:- pancreas:4.83 breast:3.90 salivary:4.57
RNA-seq uterus:- placenta:- prostate:0.00 ovary:0.32 testis:0.81 heart:0.67 muscle:0 esophagus:- stomach:- intestine:- colon:0.94     liver/hepato:0.47        lung:0.00    bladder:- kidney:0.74 pituitary:- thyroid/parathyroid:0.73 adrenal gland:0.70 pancreas:- breast:0.53 salivary:-

Gene Information

IDs

Refseq ID NM_021988
Gene ID 7335
Unigene ID Hs.420529
Probe set ID 201001_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000244687
GTEx ID ENSG00000244687

Orthologous Gene

Mouse [0]  
Rat [0]  

Chromosomal Region

20q13.13  [48,697,661  -  48,732,496]

Gene Family (Interpro ID)

IPR000608  Ubiquitin-conjugating enzyme, E2
IPR016135  Ubiquitin-conjugating enzyme/RWD-like

Link to Pubmed  (Pubmed ID)

8889548
9305758
9418904
9580084
9705497
9771976
10089880
11057907
11076848
11076860
11280764
11780052
12477932
12481031
12834344
14702039
15146197
15147900
15276183
15327770
15489334
16129784
16215985
16236267
16307917
16344560
16547522
16893187
17041755
17135271
17207965
17709375
18029035
18042044
18570872
18678647
18710948
19549727
19675569
19713527
19734906
20501938
20613989
20940148
21143188
21204785
21512569
21512573
21565611
21572451
21575904
21694720
21706008
21866272
21890473
21911421
22505724
22632162
22863883
22939629
23000965
23885119
23892723
24076975
24250222
24816145

Gene Ontology  (GO ID)

Biological Process

GO:0030154  cell differentiation
GO:0045087  innate immune response
GO:0002755  MyD88-dependent toll-like receptor signaling pathway
GO:0070423  nucleotide-binding oligomerization domain containing signaling pathway
GO:0043123  positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0051092  positive regulation of NF-kappaB transcription factor activity
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0070534  protein K63-linked ubiquitination
GO:0000209  protein polyubiquitination
GO:0006282  regulation of DNA repair
GO:0006355  regulation of transcription, DNA-dependent
GO:0050852  T cell receptor signaling pathway
GO:0034166  toll-like receptor 10 signaling pathway
GO:0034134  toll-like receptor 2 signaling pathway
GO:0034142  toll-like receptor 4 signaling pathway
GO:0034146  toll-like receptor 5 signaling pathway
GO:0034162  toll-like receptor 9 signaling pathway
GO:0002224  toll-like receptor signaling pathway

Cellular Component

GO:0005737  cytoplasm
GO:0005829  cytosol
GO:0005634  nucleus
GO:0031371  ubiquitin conjugating enzyme complex
GO:0000151  ubiquitin ligase complex

Molecular Function

GO:0016881  acid-amino acid ligase activity
GO:0005515  protein binding