wingless-type MMTV integration site family, member 5A

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Synonym

hWNT5A, Protein Wnt-5a precursor, WNT5A

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST nodata
GeneChip cerebrum:4.27 cerebellum:4.11 brain stem:4.38 corpus callosum/glia:4.26 pineal gland:- peripheral nerve:4.61 spine:4.95 retina:- eye:- artery/aorta:4.38 vein:4.31 lymphnode:5.47 peripheral blood:- spleen:4.88 thymus:4.86 bone marrow:3.94 adipose:4.95 bone:- skin:4.79
CAGE cerebrum:1.34 cerebellum:- brain stem:1.26 corpus callosum/glia:1.08 pineal gland:1.00 peripheral nerve:- spine:1.94 retina:- eye:- artery/aorta:1.38 vein:1.29 lymphnode:1.92 peripheral blood:- spleen:1.24 thymus:1.10 bone marrow:- adipose:0.36 bone:- skin:-
RNA-seq cerebrum:0.19 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0.17 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.07 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST nodata
GeneChip uterus:7.14 placenta:7.20 prostate:5.98 ovary:6.41 testis:4.94 heart:4.93 muscle:4.83 esophagus:7.46 stomach:5.18 intestine:5.64 colon:5.22 liver/hepato:4.79 lung:4.93 bladder:- kidney:4.80 pituitary:4.43 thyroid/parathyroid:5.57 adrenal gland:4.06 pancreas:4.57 breast:6.03 salivary:7.69
CAGE uterus:2.47 placenta:3.27 prostate:1.78 ovary:1.81 testis:1.23 heart:1.07 muscle:0.17 esophagus:2.30 stomach:- intestine:1.24 colon:1.70     liver/hepato:0.55    lung:1.60 bladder:1.84 kidney:1.14 pituitary:0.62 thyroid/parathyroid:1.05 adrenal gland:- pancreas:1.42 breast:1.36 salivary:3.11
RNA-seq uterus:- placenta:- prostate:0.52 ovary:1.10 testis:0.66 heart:0.34 muscle:0.19 esophagus:- stomach:- intestine:- colon:0.32     liver/hepato:0.04        lung:0.49    bladder:- kidney:0.26 pituitary:- thyroid/parathyroid:0.49 adrenal gland:0.50 pancreas:- breast:0.25 salivary:-

Gene Information

IDs

Refseq ID NM_003392
Gene ID 7474
Unigene ID -
Probe set ID 205990_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000114251
GTEx ID ENSG00000114251

Orthologous Gene

Mouse[2]  NM_009524
Rat[1]  NM_022631

Chromosomal Region

3p14.3  [55,499,743  -  55,523,973]

Gene Family (Interpro ID)

IPR005817  Wnt superfamily

Link to Pubmed  (Pubmed ID)

8167409
8288227
8537388
8889548
9054360
9787155
10491302
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11956659
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Gene Ontology  (GO ID)

Biological Process

GO:0007257  activation of JUN kinase activity
GO:0000187  activation of MAPK activity
GO:0032148  activation of protein kinase B activity
GO:0001667  ameboidal cell migration
GO:0007411  axon guidance
GO:0051216  cartilage development
GO:0045165  cell fate commitment
GO:0034613  cellular protein localization
GO:0071277  cellular response to calcium ion
GO:0071346  cellular response to interferon-gamma
GO:0071222  cellular response to lipopolysaccharide
GO:0071300  cellular response to retinoic acid
GO:0060067  cervix development
GO:0090103  cochlea morphogenesis
GO:0060029  convergent extension involved in organogenesis
GO:0008595  determination of anterior/posterior axis, embryo
GO:0042733  embryonic digit morphogenesis
GO:0048706  embryonic skeletal system development
GO:0060750  epithelial cell proliferation involved in mammary gland duct elongation
GO:0001837  epithelial to mesenchymal transition
GO:0001736  establishment of planar polarity
GO:0060324  face development
GO:0048806  genitalia development
GO:0001947  heart looping
GO:0071425  hemopoietic stem cell proliferation
GO:0007442  hindgut morphogenesis
GO:0048850  hypophysis morphogenesis
GO:0030216  keratinocyte differentiation
GO:0060599  lateral sprouting involved in mammary gland duct morphogenesis
GO:0002088  lens development in camera-type eye
GO:0030324  lung development
GO:0008584  male gonad development
GO:0060744  mammary gland branching involved in thelarche
GO:0060638  mesenchymal-epithelial cell signaling
GO:0007494  midgut development
GO:0050919  negative chemotaxis
GO:0043066  negative regulation of apoptosis
GO:0048843  negative regulation of axon extension involved in axon guidance
GO:0030514  negative regulation of BMP signaling pathway
GO:0050680  negative regulation of epithelial cell proliferation
GO:0045599  negative regulation of fat cell differentiation
GO:0040037  negative regulation of fibroblast growth factor receptor signaling pathway
GO:0060686  negative regulation of prostatic bud formation
GO:0051964  negative regulation of synaptogenesis
GO:0045892  negative regulation of transcription, DNA-dependent
GO:0090090  negative regulation of Wnt receptor signaling pathway through beta-catenin
GO:0001843  neural tube closure
GO:0030182  neuron differentiation
GO:0021891  olfactory bulb interneuron development
GO:0003408  optic cup formation involved in camera-type eye development
GO:0060021  palate development
GO:0003323  pancreatic B cell development
GO:0090179  planar cell polarity pathway involved in neural tube closure
GO:0045766  positive regulation of angiogenesis
GO:0030825  positive regulation of cGMP metabolic process
GO:0045080  positive regulation of chemokine biosynthetic process
GO:0002741  positive regulation of cytokine secretion during immune response
GO:0010595  positive regulation of endothelial cell migration
GO:0001938  positive regulation of endothelial cell proliferation
GO:0048146  positive regulation of fibroblast proliferation
GO:0050729  positive regulation of inflammatory response
GO:0032729  positive regulation of interferon-gamma production
GO:0050718  positive regulation of interleukin-1 beta secretion
GO:0032755  positive regulation of interleukin-6 production
GO:0046330  positive regulation of JNK cascade
GO:0043032  positive regulation of macrophage activation
GO:0060907  positive regulation of macrophage cytokine production
GO:0045836  positive regulation of meiosis
GO:0002053  positive regulation of mesenchymal cell proliferation
GO:0010976  positive regulation of neuron projection development
GO:0051092  positive regulation of NF-kappaB transcription factor activity
GO:0045778  positive regulation of ossification
GO:0033138  positive regulation of peptidyl-serine phosphorylation
GO:0010800  positive regulation of peptidyl-threonine phosphorylation
GO:0045732  positive regulation of protein catabolic process
GO:0090037  positive regulation of protein kinase C signaling cascade
GO:0060760  positive regulation of response to cytokine stimulus
GO:0010820  positive regulation of T cell chemotaxis
GO:0070245  positive regulation of thymocyte apoptosis
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0060340  positive regulation of type I interferon-mediated signaling pathway
GO:0090009  primitive streak formation
GO:0006468  protein amino acid phosphorylation
GO:0060762  regulation of branching involved in mammary gland duct morphogenesis
GO:0010033  response to organic substance
GO:0001756  somitogenesis
GO:0060157  urinary bladder development
GO:0060065  uterus development
GO:0060068  vagina development
GO:0016055  Wnt receptor signaling pathway
GO:0060070  Wnt receptor signaling pathway through beta-catenin
GO:0007223  Wnt receptor signaling pathway, calcium modulating pathway
GO:0042060  wound healing

Cellular Component

GO:0009986  cell surface
GO:0005788  endoplasmic reticulum lumen
GO:0005576  extracellular region
GO:0005615  extracellular space
GO:0005796  Golgi lumen
GO:0005886  plasma membrane
GO:0005578  proteinaceous extracellular matrix

Molecular Function

GO:0005125  cytokine activity
GO:0044212  DNA regulatory region binding
GO:0005109  frizzled binding
GO:0005110  frizzled-2 binding
GO:0019904  protein domain specific binding
GO:0048018  receptor agonist activity
GO:0005115  receptor tyrosine kinase-like orphan receptor binding
GO:0003700  transcription factor activity