wingless-type MMTV integration site family, member 7B

 jump to detail

Synonym

Protein Wnt-7b precursor, WNT7B

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:8.30 cerebellum:12.60 brain stem:- corpus callosum/glia:29.20 pineal gland:- peripheral nerve:- spine:- retina:- eye:35.30 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:9.60
GeneChip cerebrum:4.40 cerebellum:4.26 brain stem:4.46 corpus callosum/glia:4.06 pineal gland:- peripheral nerve:4 spine:4.03 retina:- eye:- artery/aorta:4.15 vein:4.30 lymphnode:4.10 peripheral blood:- spleen:3.96 thymus:3.79 bone marrow:4.16 adipose:4.08 bone:- skin:4.76
CAGE cerebrum:1.03 cerebellum:- brain stem:0.55 corpus callosum/glia:0.82 pineal gland:0 peripheral nerve:- spine:0.17 retina:- eye:- artery/aorta:0.47 vein:0 lymphnode:0.77 peripheral blood:- spleen:0 thymus:0.23 bone marrow:- adipose:0 bone:- skin:-
RNA-seq cerebrum:0.57 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0.05 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.03 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:- ovary:- testis:- heart:12.80 muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:4.90    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip uterus:4.11 placenta:3.78 prostate:4.22 ovary:4.08 testis:3.93 heart:4.23 muscle:4.41 esophagus:4.59 stomach:4.11 intestine:4.26 colon:4.29 liver/hepato:4.08 lung:4.10 bladder:- kidney:4.50 pituitary:4.11 thyroid/parathyroid:3.95 adrenal gland:4.19 pancreas:4.19 breast:4.07 salivary:4.09
CAGE uterus:0.85 placenta:0.59 prostate:1.56 ovary:0.47 testis:0.37 heart:0 muscle:0 esophagus:2.17 stomach:- intestine:0 colon:0     liver/hepato:0    lung:1.30 bladder:1.69 kidney:0.67 pituitary:0.10 thyroid/parathyroid:0.17 adrenal gland:- pancreas:0.94 breast:0 salivary:0
RNA-seq uterus:- placenta:- prostate:1.56 ovary:0.39 testis:0.35 heart:0 muscle:0.00 esophagus:- stomach:- intestine:- colon:0.00     liver/hepato:0.01        lung:1.27    bladder:- kidney:0.55 pituitary:- thyroid/parathyroid:0.08 adrenal gland:0.00 pancreas:- breast:0.16 salivary:-

Gene Information

IDs

Refseq ID NM_058238
Gene ID 7477
Unigene ID Hs.512714
Probe set ID 217681_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000188064
GTEx ID ENSG00000188064

Orthologous Gene

Mouse[6]  NM_001163633, NM_001163634, NM_009528
Rat[1]  NM_001009695, NM_001163634, NM_009528

Chromosomal Region

22q13.31  [46,316,242  -  46,373,009]

Gene Family (Interpro ID)

IPR005816  Secreted growth factor Wnt protein
IPR005817  Wnt superfamily
IPR013300  Wnt-7 protein

Link to Pubmed  (Pubmed ID)

8167409
8168088
8889548
9284940
10866835
11562755
12239632
12429992
12477932
14702039
15164427
15489334
16227623
16258938
17207965
19734317
19863181
20634891
21732829
21988832
22838404
22949635
23386686
23416978

Gene Ontology  (GO ID)

Biological Process

GO:0060033  anatomical structure regression
GO:0045165  cell fate commitment
GO:0007267  cell-cell signaling
GO:0044237  cellular metabolic process
GO:0071300  cellular response to retinoic acid
GO:0022009  central nervous system vasculogenesis
GO:0060710  chorio-allantoic fusion
GO:0060560  developmental growth involved in morphogenesis
GO:0048568  embryonic organ development
GO:0060669  embryonic placenta morphogenesis
GO:0016332  establishment or maintenance of polarity of embryonic epithelium
GO:0048144  fibroblast proliferation
GO:0021871  forebrain regionalization
GO:0042592  homeostatic process
GO:0001701  in utero embryonic development
GO:0006917  induction of apoptosis
GO:0070307  lens fiber cell development
GO:0060482  lobar bronchus development
GO:0030324  lung development
GO:0060428  lung epithelium development
GO:0060425  lung morphogenesis
GO:0060484  lung-associated mesenchyme development
GO:0003338  metanephros morphogenesis
GO:0007275  multicellular organismal development
GO:0045879  negative regulation of smoothened signaling pathway
GO:0030182  neuron differentiation
GO:0042475  odontogenesis of dentine-containing tooth
GO:0032364  oxygen homeostasis
GO:0008284  positive regulation of cell proliferation
GO:0010628  positive regulation of gene expression
GO:0046330  positive regulation of JNK cascade
GO:0045669  positive regulation of osteoblast differentiation
GO:0051145  smooth muscle cell differentiation
GO:0050808  synapse organization
GO:0060535  trachea cartilage morphogenesis
GO:0016055  Wnt receptor signaling pathway
GO:0060070  Wnt receptor signaling pathway through beta-catenin

Cellular Component

GO:0005788  endoplasmic reticulum lumen
GO:0005576  extracellular region
GO:0005615  extracellular space
GO:0005796  Golgi lumen
GO:0005886  plasma membrane
GO:0005578  proteinaceous extracellular matrix

Molecular Function

GO:0005201  extracellular matrix structural constituent
GO:0005109  frizzled binding