discoidin domain receptor tyrosine kinase 1

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Synonym

CD167a antigen, TRKE, EDDR1, CD167, Tyrosine kinase DDR, NEP, PTK3A, PTK3, Epithelial discoidin domain receptor 1, discoidin domain receptor family, member 1, HGK2, DDR, Tyrosine-protein kinase CAK, Cell adhesion kinase, DDR1, Discoidin receptor tyrosine kinase, Protein-tyrosine kinase RTK 6, TRK E, NTRK4, MCK10, RTK6

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:513.20 cerebellum:466 brain stem:- corpus callosum/glia:145.80 pineal gland:148.30 peripheral nerve:61.30 spine:112.30 retina:- eye:129.30 artery/aorta:- vein:- lymphnode:30.30 peripheral blood:- spleen:18.90 thymus:335 bone marrow:- adipose:- bone:89.60 skin:96
GeneChip cerebrum:9.49 cerebellum:8.38 brain stem:9.74 corpus callosum/glia:10.56 pineal gland:- peripheral nerve:8.41 spine:10.66 retina:- eye:- artery/aorta:8 vein:7.56 lymphnode:7.92 peripheral blood:- spleen:7.54 thymus:8.66 bone marrow:7.50 adipose:7.90 bone:- skin:8.86
CAGE cerebrum:4.44 cerebellum:- brain stem:5.01 corpus callosum/glia:5.47 pineal gland:3.38 peripheral nerve:- spine:5.31 retina:- eye:- artery/aorta:3.25 vein:3.04 lymphnode:2.75 peripheral blood:- spleen:2.07 thymus:3.46 bone marrow:- adipose:2.52 bone:- skin:-
RNA-seq cerebrum:0 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:100.20 placenta:120.20 prostate:78.90 ovary:111.80 testis:73.50 heart:76.60 muscle:20.10 esophagus:- stomach:42.50 intestine:64.80 colon:110.20     liver/hepato:10.60        lung:395.90    bladder:125.60 kidney:10.40 pituitary:116 thyroid/parathyroid:491.20 adrenal gland:- pancreas:257.80 breast:111.50 salivary:-
GeneChip uterus:8.24 placenta:9.23 prostate:9.21 ovary:8.88 testis:7.73 heart:7.73 muscle:7.47 esophagus:9.38 stomach:8.74 intestine:8.58 colon:8.76 liver/hepato:7.26 lung:8.35 bladder:- kidney:9.15 pituitary:9.32 thyroid/parathyroid:9.80 adrenal gland:8.42 pancreas:8.76 breast:9.48 salivary:9.48
CAGE uterus:3.17 placenta:3.92 prostate:3.65 ovary:3.30 testis:3.10 heart:2.75 muscle:3.00 esophagus:4.15 stomach:- intestine:4.08 colon:3.97     liver/hepato:1.81    lung:3.87 bladder:3.14 kidney:4.04 pituitary:3.78 thyroid/parathyroid:4.23 adrenal gland:- pancreas:4.05 breast:3.96 salivary:4.70
RNA-seq uterus:- placenta:- prostate:0 ovary:0 testis:0 heart:0 muscle:0 esophagus:- stomach:- intestine:- colon:0     liver/hepato:0        lung:0    bladder:- kidney:0 pituitary:- thyroid/parathyroid:0 adrenal gland:0 pancreas:- breast:0 salivary:-

Gene Information

IDs

Refseq ID NM_001954
Gene ID 780
Unigene ID Hs.631988
Probe set ID 1007_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000204580
ENSG00000215522
ENSG00000234078
GTEx ID ENSG00000204580
ENSG00000215522
ENSG00000234078

Orthologous Gene

Mouse[10]  NM_001198831, NM_001198833, NM_007584, NM_172962
Rat[6]  NM_001166022, NM_013137, NM_007584, NM_172962

Chromosomal Region

6p21.33  [30,844,198  -  30,867,933]
HSCHR6_MHC_APD  [30,861,248  -  30,865,452]
HSCHR6_MHC_QBL  [30,838,342  -  30,857,525]
HSCHR6_MHC_MANN  [30,893,440  -  30,912,617]
HSCHR6_MHC_MCF  [30,927,312  -  30,938,427]
HSCHR6_MHC_DBB  [30,839,458  -  30,858,654]
HSCHR6_MHC_COX  [30,838,646  -  30,857,829]

Gene Family (Interpro ID)

IPR000421  Coagulation factor 5/8 type, C-terminal
IPR008979  Galactose-binding domain-like
IPR000719  Protein kinase, catalytic domain
IPR011009  Protein kinase-like domain
IPR002290  Serine/threonine-protein kinase domain
IPR017442  Serine/threonine-protein kinase-like domain
IPR001245  Tyrosine-protein kinase, catalytic domain
IPR020635  Tyrosine-protein kinase, subgroup, catalytic domain

Link to Pubmed  (Pubmed ID)

7774938
7789998
7834423
7848919
8139570
8226977
8302582
8390675
8622863
8682498
8796349
8977099
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9492013
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10681566
10783152
11126911
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11606478
12065315
12477932
12935821
14574404
14764702
15111304
15136580
15146197
15213330
15240533
15489334
16169070
16337946
16440311
16502470
16702430
16774916
16912190
17001518
17027969
17101694
17299390
17440435
17440927
17704737
17721511
17970783
17982627
18023033
18065762
18190796
18270328
18362184
18593464
18836851
19199708
19262089
19401332
19752756
19837266
19851445
20007060
20041166
20093046
20182441
20219323
20353877
20372823
20380825
20487506
20587610
20596615
20799954
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21551363
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22507556
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22895534
22939624
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23307244
23335507
23382212
23455636
23519472
23530036
23761027
23810922
24018687
24136166
24509848
24671415

Gene Ontology  (GO ID)

Biological Process

GO:0060444  branching involved in mammary gland duct morphogenesis
GO:0007155  cell adhesion
GO:0043583  ear development
GO:0007566  embryo implantation
GO:0030198  extracellular matrix organization
GO:0007595  lactation
GO:0060749  mammary gland alveolus development
GO:0008285  negative regulation of cell proliferation
GO:0046777  protein amino acid autophosphorylation
GO:0001558  regulation of cell growth
GO:0001952  regulation of cell-matrix adhesion
GO:0010715  regulation of extracellular matrix disassembly
GO:0014909  smooth muscle cell migration

Cellular Component

GO:0005576  extracellular region
GO:0005887  integral to plasma membrane
GO:0005886  plasma membrane

Molecular Function

GO:0005524  ATP binding
GO:0005518  collagen binding
GO:0046872  metal ion binding
GO:0005515  protein binding
GO:0004714  transmembrane receptor protein tyrosine kinase activity