chemokine (C-X-C motif) receptor 4

jump to detail

Synonym

WHIM, SDF-1 receptor, NPY3R, NPYY3R, C-X-C chemokine receptor type 4, FB22, LAP3, Fusin, chemokine (C-X-C motif) receptor 4, CXCR-4, LCR1, Stromal cell-derived factor 1 receptor, NPYR, HM89, fusin, HSY3RR, CXC-R4, CD184 antigen, NPYRL, D2S201E, CD184, LESTR, CXCR4

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:1.20 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:5.90 artery/aorta:- vein:- lymphnode:50.60 peripheral blood:36.40 spleen:- thymus:12.90 bone marrow:19.70 adipose:- bone:- skin:-
GeneChip cerebrum:5.12 cerebellum:4.53 brain stem:5.37 corpus callosum/glia:6.46 pineal gland:- peripheral nerve:7.67 spine:7.52 retina:- eye:- artery/aorta:7.55 vein:7.42 lymphnode:10.39 peripheral blood:- spleen:10.78 thymus:10.92 bone marrow:11.58 adipose:7.82 bone:- skin:6.67
CAGE cerebrum:2.35 cerebellum:- brain stem:3.33 corpus callosum/glia:3.71 pineal gland:2.76 peripheral nerve:- spine:4.59 retina:- eye:- artery/aorta:4.53 vein:6.10 lymphnode:6.31 peripheral blood:- spleen:6.08 thymus:6.80 bone marrow:- adipose:4.53 bone:- skin:-
RNA-seq cerebrum:0.24 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:3.94 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.04 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:7.30 prostate:11.30 ovary:- testis:- heart:- muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:21.10        lung:9.80    bladder:- kidney:20.80 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip uterus:7.37 placenta:7.39 prostate:6.81 ovary:7.48 testis:4.69 heart:6.68 muscle:5.11 esophagus:5.97 stomach:8.17 intestine:7.45 colon:7.89 liver/hepato:6.48 lung:9.94 bladder:- kidney:5.89 pituitary:7 thyroid/parathyroid:7.40 adrenal gland:9.94 pancreas:6.15 breast:7.47 salivary:6.10
CAGE uterus:3.95 placenta:3.48 prostate:3.75 ovary:3.64 testis:3.35 heart:3.02 muscle:1.93 esophagus:4.58 stomach:- intestine:4.23 colon:3.82     liver/hepato:3.60    lung:5.20 bladder:5.69 kidney:3.75 pituitary:3.29 thyroid/parathyroid:3.91 adrenal gland:- pancreas:2.94 breast:4.05 salivary:3.76
RNA-seq uterus:- placenta:- prostate:0.00 ovary:0.58 testis:0.50 heart:0.17 muscle:0.00 esophagus:- stomach:- intestine:- colon:0.00     liver/hepato:0.56        lung:2.40    bladder:- kidney:0.30 pituitary:- thyroid/parathyroid:0.25 adrenal gland:4.52 pancreas:- breast:0.28 salivary:-

IDs

Refseq ID NM_001008540
Gene ID 7852
Unigene ID Hs.593413
Probe set ID 217028_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000121966
GTEx ID ENSG00000121966

Orthologous Gene

Mouse[1]  NM_009911
Rat [0]  

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed  (Pubmed ID)

1187744
2834384
7505609
7592830
8234909
8276799
8325644
8329116
8629022
8640552
8674119
8752280
8752281
8805353
8849450
8898753
8929542
8976200
8995603
9020356
9024623
9031325
9151868
9184207
9261451
9300725
9302439
9359702
9362541
9379028
9461627
9468539
9499113
9499115
9599023
9600268
9601645
9614108
9632631
9634237
9634238
9653051
9653130
9658081
9696823
9710449
9721247
9736741
9744279
9765440
9770524
9780207
9826718
9879064
9882290
9933168
9973525
10029247
10074122
10089882
10228019
10229873
10233851
10329539
10339592
10357469
10358157
10364484
10370370
10371171
10393923
10393974
10415069
10430052
10438703
10438870
10446313
10449282
10452968
10480633
10482576
10487781
10505675
10506573
10521508
10544150
10555208
10559349
10570282
10582593
10583963
10585143
10590105
10590121
10600606
10602722
10623764
10644702
10651866
10669334
10704341
10738970
10754293
10756055
10758170
10772939
10801487
10802710
10816381
10825158
10860877
10864687
10875613
10877489
10903911
10903920
10941932
10942389
11005830
11024154
11027346
11069996
11086073
11115360
11118068
11119612
11141237
11153675
11157475
11162626
11162839
11175286
11264367
11265761
11278278
11278567
11313374
11333905
11342415
11356952
11356967
11390582
11390601
11397808
11408611
11413305
11414813
11426226
11462036
11464139
11468147
11489906
11517394
11529558
11533159
11551942
11559423
11591141
11591370
11595336
11602639
11602715
11641392
11668182
11679153
11689632
11693435
11698270
11709091
11711593
11711617
11751889
11752220
11799176
11861874
11867624
11876757
11877445
11878912
11880384
11912162
11920324
11929756
11931835
11937572
11953881
11983855
11994484
11994538
12004084
12034737
12091904
12093918
12163560
12171912
12193696
12208881
12218052
12239139
12239174
12351385
12354773
12355376
12356205
12368305
12368322
12370187
12388552
12393569
12393663
12421915
12429730
12433920
12477874
12477932
12485835
12488503
12490404
12499259
12502809
12519755
12519884
12531874
12551992
12555203
12555204
12586555
12605695
12609846
12634405
12651900
12690099
12692554
12705474
12713058
12726730
12730102
12761880
12766157
12775414
12783211
12791666
12832058
12834106
12843275
12853157
12857973
12871111
12873764
12873765
12882655
12882661
12894851
12927045
12960231
12963807
13679920
14505910
14555820
14567988
14576059
14592831
14595012
14597738
14602072
14630801
14640682
14672331
14684377
14688392
14694113
14715575
14764445
14973260
14982745
14988150
14990703
14990729
14995074
15019705
15026622
15033669
15033938
15047829
15048928
15054042
15113900
15117454
15123627
15128813
15161081
15169555
15174142
15180966
15183061
15184910
15201990
15225616
15235108
15251986
15258189
15279544
15308751
15327899
15328152
15328206
15351504
15358596
15363550
15377464
15452229
15454484
15467730
15479838
15486895
15489334
15492752
15509740
15536192
15540205
15542430
15548713
15548717
15549771
15585097
15585836
15588345
15598422
15608062
15615703
15618472
15632118
15650174
15660419
15662133
15670831
15681827
15687242
15701832
15705741
15710459
15719026
15737629
15748209
15753377
15781337
15784966
15787642
15794931
15802268
15805285
15806155
15814634
15819887
15831676
15843590
15844659
15857508
15867478
15880586
15890935
15972662
15992849
15995960
15998835
16005638
16044003
16047221
16084492
16114056
16172123
16179731
16188969
16204649
16227248
16230077
16236267
16284526
16306611
16322285
16327980
16365278
16368946
16375941
16378977
16467205
16489019
16494043
16494621
16524887
16528367
16585856
16618732
16621978
16631222
16638848
16675573
16679918
16697675
16702010
16740704
16756721
16756955
16784459
16802356
16823836
16836911
16841089
16863915
16877302
16886061
16888620
16919488
16928758
16929169
16929176
16942785
16943240
16946301
16948134
16948905
16966601
16969502
16978607
16987062
16990599
17010165
17011204
17023512
17032700
17038674
17056591
17070589
17075975
17077324
17082613
17119115
17121788
17130833
17136117
17176471
17188679
17198877
17202224
17251291
17253948
17262717
17327270
17328229
17328838
17329448
17331556
17346946
17350297
17355795
17379424
17411375
17435771
17456315
17457084
17459055
17461449
17476338
17488655
17504381
17507467
17507486
17510563
17521613
17545018
17559806
17562613
17574038
17582634
17594938
17596666
17606439
17620369
17634424
17640743
17641542
17650669
17676665
17687643
17706641
17715128
17715399
17763975
17765649
17768666
17846797
17875700
17881971
17888880
17889832
17893878
17894415
17895991
17916907
17925864
17947233
17947541
17959679
17964871
17977968
17991743
18036244
18037996
18040858
18081034
18083706
18087217
18089812
18097955
18155192
18175225
18182005
18187620
18190699
18200497
18201276
18206727
18210030
18219852
18234887
18235009
18239145
18240029
18242797
18267010
18274673
18281050
18286257
18288973
18292939
18334485
18337451
18339860
18339870
18353956
18357387
18365549
18373506
18416455
18431597
18438604
18443596
18448868
18461161
18468560
18480460
18487224
18500445
18502034
18511598
18519809
18524826
18556411
18562079
18568019
18570923
18577758
18593989
18599607
18624931
18632580
18634924
18636124
18653785
18692524
18696160
18698020
18701133
18707241
18753930
18760838
18760839
18765807
18769446
18775311
18781098
18784079
18788547
18798091
18799424
18803056
18807177
18808680
18812968
18815295
18820725
18829537
18834145
18836306
18851783
18923649
18925934
18948617
18949410
18954561
18957686
18958626
18976975
18977142
18991615
19002187
19008040
19017998
19019622
19020538
19020745
19025611
19035451
19042019
19053768
19057930
19064997
19066282
19074885
19082444
19106094
19107931
19113880
19115008
19116316
19125297
19134328
19136936
19139298
19147814
19148483
19149577
19178925
19196101
19199057
19200444
19212630
19228923
19232661
19240061
19252530
19260802
19272813
19297481
19302975
19305148
19327121
19335218
19336475
19336886
19339951
19339953
19340288
19351212
19352387
19366992
19373784
19379572
19379577
19379578
19391039
19414793
19433312
19438749
19449444
19460858
19472013
19473177
19476565
19492159
19494283
19496172
19497995
19513547
19513623
19520808
19521120
19523923
19525448
19525953
19526283
19540208
19550128
19551455
19563077
19567784
19568410
19570110
19580679
19584257
19588204
19593633
19605489
19615218
19615279
19654311
19665027
19671192
19688824
19692474
19703720
19716197
19730683
19731977
19735481
19761697
19762327
19765831
19769961
19774645
19784070
19796655
19812192
19812382
19816083
19816596
19820417
19825996
19830694
19837984
19859817
19879194
19885584
19906780
19912363
19913121
19921580
19923906
19932585
19950235
19956569
20007689
20018238
20023696
20025867
20028517
20035824
20036848
20048153
20051874
20053635
20067991
20068066
20071457
20084476
20102637
20109310
20118565
20133817
20134207
20141446
20154716
20159979
20177796
20196768
20206813
20228059
20338046
20349215
20380698
20386750
20388788
20388803
20421499
20439195
20450430
20460402
20462600
20465832
20484957
20492653
20502526
20505072
20525755
20540706
20561415
20563655
20568229
20573729
20573813
20578990
20580677
20585037
20594270
20594957
20598333
20599766
20603605
20607251
20616219
20622011
20628086
20629312
20629629
20637871
20646340
20646838
20651371
20660740
20661303
20661426
20699000
20705717
20708218
20710056
20722038
20723431
20728717
20801883
20802527
20829512
20842205
20847314
20859707
20861157
20861743
20865359
20876529
20921899
20923564
20929726
20953377
20956518
20972812
21048156
21052687
21059341
21070597
21071054
21076047
21080209
21082982
21087342
21087446
21093051
21110890
21127401
21138752
21139054
21152581
21156016
21158728
21178277
21186999
21188555
21205837
21238532
21264298
21292343
21295814
21300944
21304904
21312239
21321123
21349176
21349998
21350711
21357602
21381021
21402361
21435112
21447649
21454012
21459858
21463876
21468602
21506920
21513481
21518481
21521526
21525208
21527066
21530075
21537329
21553525
21555814
21567400
21569409
21573951
21607621
21607655
21618080
21623238
21623830
21624427
21627959
21630055
21631268
21633638
21655198
21655330
21656184
21668366
21670103
21676905
21680174
21695171
21705626
21720384
21723943
21728385
21730065
21731496
21738044
21740294
21757744
21760891
21802105
21802140
21818756
21831961
21835796
21878648
21887463
21890473
21906588
21906874
21909080
21909361
21931863
21934106
21948620
21951552
21963094
21969820
21985848
21986127
21987572
21988832
21994672
22018245
22023092
22025564
22039044
22052462
22074556
22075627
22084248
22101518
22103833
22103834
22114110
22133596
22152016
22157596
22169254
22169298
22175768
22200669
22220212
22220905
22226668
22232208
22238325
22242160
22245379
22253872
22266857
22266861
22275353
22292949
22297516
22299827
22313935
22333149
22342838
22359577
22362916
22366438
22370645
22370717
22377565
22427920
22427929
22430135
22450749
22463589
22471472
22472349
22479424
22490156
22495096
22496149
22496601
22505724
22526457
22532631
22537596
22541097
22547906
22549810
22554649
22568557
22582975
22596258
22634622
22644306
22645275
22657741
22673499
22682478
22683307
22688512
22689289
22699677
22706111
22727731
22728273
22732432
22745793
22767589
22779681
22784557
22802411
22808111
22830600
22847686
22848341
22852142
22871210
22885527
22902648
22908191
22914607
22916293
22923991
22925564
22932666
22936065
22941282
22952422
22954962
22980333
22987307
22995914
23023480
23039915
23043103
23043104
23046610
23053994
23075330
23082154
23133664
23148226
23160836
23177198
23197643
23216236
23219524
23223005
23223950
23224761
23231927
23244336
23259294
23263827
23279723
23288365
23297034
23321466
23326587
23331013
23341955
23344887
23349771
23369572
23395387
23421710
23434321
23443279
23446039
23468933
23469143
23472069
23472074
23490053
23495012
23497290
23497377
23526079
23528817
23544621
23555768
23563306
23565284
23575248
23591873
23609324
23623275
23647548
23652361
23659571
23669361
23672855
23676502
23688427
23692808
23697661
23702796
23710557
23714687
23726130
23728080
23734232
23744460
23744532
23745959
23754844
23758411
23765204
23769877
23773022
23773308
23777983
23794067
23794207
23798675
23802178
23817178
23827153
23842123
23845465
23849988
23856244
23856897
23863999
23865743
23868972
23886194
23895705
23911867
23918302
23918819
23921147
23924922
23925152
23934537
23935395
23936528
23954894
23963832
23966000
23987636
24005135
24014104
24023356
24023874
24027570
24032722
24035716
24040160
24048002
24052640
24086760
24091662
24094005
24101191
24101523
24155926
24157575
24170200
24174685
24175834
24184476
24215935
24238971
24239175
24288553
24330809
24366360
24373354
24390633
24398989
24448360
24452472
24480462
24489825
24553177
24644030
24714746
24778234
24790097

Gene Ontology  (GO ID)

Biological Process

GO:0000187  activation of MAPK activity
GO:0001667  ameboidal cell migration
GO:0006915  apoptosis
GO:0007420  brain development
GO:0019722  calcium-mediated signaling
GO:0002407  dendritic cell chemotaxis
GO:0007204  elevation of cytosolic calcium ion concentration
GO:0030260  entry into host cell
GO:0007186  G-protein coupled receptor protein signaling pathway
GO:0007281  germ cell development
GO:0008354  germ cell migration
GO:0006954  inflammatory response
GO:0008045  motor axon guidance
GO:0043217  myelin maintenance
GO:0001764  neuron migration
GO:0042119  neutrophil activation
GO:0001569  patterning of blood vessels
GO:0048714  positive regulation of oligodendrocyte differentiation
GO:0030334  regulation of cell migration
GO:0050920  regulation of chemotaxis
GO:0001666  response to hypoxia
GO:0009615  response to virus
GO:0042098  T cell proliferation
GO:0016032  viral reproduction
GO:0019048  virus-host interaction

Cellular Component

GO:0031252  cell leading edge
GO:0009986  cell surface
GO:0005737  cytoplasm
GO:0016023  cytoplasmic membrane-bounded vesicle
GO:0031410  cytoplasmic vesicle
GO:0009897  external side of plasma membrane
GO:0030426  growth cone
GO:0016021  integral to membrane
GO:0005886  plasma membrane

Molecular Function

GO:0003779  actin binding
GO:0016494  C-X-C chemokine receptor activity
GO:0015026  coreceptor activity
GO:0019955  cytokine binding
GO:0004930  G-protein coupled receptor activity
GO:0032027  myosin light chain binding
GO:0005515  protein binding
GO:0043130  ubiquitin binding
GO:0031625  ubiquitin protein ligase binding