frizzled homolog 5 (Drosophila)

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Synonym

frizzled (Drosophila) homolog 5, Frizzled-5 precursor, FZD5, DKFZP434E2135, HFZ5, MGC129692, FzE5, hFz5, frizzled homolog 5 (Drosophila), Fz-5, Hfz5, C2orf31

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:1.20 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:118.60 eye:41.10 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:9.60
GeneChip cerebrum:4.26 cerebellum:3.81 brain stem:4.28 corpus callosum/glia:5.28 pineal gland:- peripheral nerve:4.10 spine:4.30 retina:- eye:- artery/aorta:4.88 vein:4.07 lymphnode:4.50 peripheral blood:- spleen:4.75 thymus:4.85 bone marrow:5.44 adipose:5.03 bone:- skin:4.67
CAGE cerebrum:1.60 cerebellum:- brain stem:2.21 corpus callosum/glia:2.88 pineal gland:0.92 peripheral nerve:- spine:1.58 retina:- eye:- artery/aorta:1.94 vein:1.65 lymphnode:1.85 peripheral blood:- spleen:2.04 thymus:1.41 bone marrow:- adipose:2.59 bone:- skin:-
RNA-seq cerebrum:1.04 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:1.01 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:1.76 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:27.30 placenta:18.20 prostate:- ovary:- testis:8.70 heart:- muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:44.50 breast:9.30 salivary:-
GeneChip uterus:5.61 placenta:5.52 prostate:7.36 ovary:5.03 testis:3.66 heart:4.17 muscle:4.78 esophagus:4.97 stomach:6.88 intestine:6.70 colon:7.06 liver/hepato:7.80 lung:6.17 bladder:- kidney:5.77 pituitary:5.26 thyroid/parathyroid:7.26 adrenal gland:5.81 pancreas:7.05 breast:4.66 salivary:5.27
CAGE uterus:2.07 placenta:2.70 prostate:2.66 ovary:2.11 testis:1.28 heart:1.48 muscle:1.83 esophagus:2.41 stomach:- intestine:4.36 colon:4.21     liver/hepato:4.30    lung:3.55 bladder:1.98 kidney:3.30 pituitary:1.67 thyroid/parathyroid:3.72 adrenal gland:- pancreas:3.87 breast:2.79 salivary:2.17
RNA-seq uterus:- placenta:- prostate:1.38 ovary:1.55 testis:0.87 heart:0.72 muscle:0.69 esophagus:- stomach:- intestine:- colon:2.86     liver/hepato:3.60        lung:2.37    bladder:- kidney:2.46 pituitary:- thyroid/parathyroid:2.63 adrenal gland:1.13 pancreas:- breast:2.37 salivary:-

Gene Information

IDs

Refseq ID NM_003468
Gene ID 7855
Unigene ID Hs.17631
Probe set ID 221245_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000163251
GTEx ID ENSG00000163251

Orthologous Gene

Mouse[2]  NM_001042659, NM_022721
Rat[1]  NM_173838, NM_022721

Chromosomal Region

2q33.3  [208,627,310  -  208,634,287]

Gene Family (Interpro ID)

IPR000539  Frizzled protein
IPR020067  Frizzled-like domain
IPR017981  GPCR, family 2-like

Link to Pubmed  (Pubmed ID)

8626800
9054360
9192640
9707618
10906785
11029007
11230166
11408929
11520064
12121999
12477932
12490564
12839624
12857724
15338479
15370539
15694380
15815621
16601243
16890161
17273778
18077588
18174455
18230341
18838381
19453261
19543507
19643732
20227366
20525402
21344486
21900206
21988832
23337955
23610556
24706725

Gene Ontology  (GO ID)

Biological Process

GO:0001525  angiogenesis
GO:0006915  apoptosis
GO:0060561  apoptosis involved in morphogenesis
GO:0007409  axonogenesis
GO:0007420  brain development
GO:0048469  cell maturation
GO:0071219  cellular response to molecule of bacterial origin
GO:0008595  determination of anterior/posterior axis, embryo
GO:0000578  embryonic axis specification
GO:0031076  embryonic camera-type eye development
GO:0008406  gonad development
GO:0060716  labyrinthine layer blood vessel development
GO:0008285  negative regulation of cell proliferation
GO:0030182  neuron differentiation
GO:0032729  positive regulation of interferon-gamma production
GO:0043507  positive regulation of JUN kinase activity
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0031077  post-embryonic camera-type eye development
GO:0060061  Spemann organizer formation
GO:0033077  T cell differentiation in the thymus
GO:0060070  Wnt receptor signaling pathway through beta-catenin

Cellular Component

GO:0042995  cell projection
GO:0009986  cell surface
GO:0005737  cytoplasm
GO:0000139  Golgi membrane
GO:0016021  integral to membrane
GO:0048471  perinuclear region of cytoplasm
GO:0005886  plasma membrane

Molecular Function

GO:0004930  G-protein coupled receptor activity
GO:0030165  PDZ domain binding
GO:0005515  protein binding
GO:0019901  protein kinase binding
GO:0031625  ubiquitin protein ligase binding
GO:0042813  Wnt receptor activity
GO:0017147  Wnt-protein binding