WD repeat domain 77

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Synonym

MGC2722, WD repeat domain 77, MEP50 protein, HKMT1069, WDR77, WD repeat protein 77, Nbla10071, MEP50, Methylosome protein 50, RP11-552M11.3

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:129.20 cerebellum:75.60 brain stem:- corpus callosum/glia:116.60 pineal gland:148.30 peripheral nerve:30.70 spine:- retina:- eye:47 artery/aorta:239.80 vein:133.30 lymphnode:111.20 peripheral blood:145.70 spleen:208 thymus:257.70 bone marrow:19.70 adipose:80.70 bone:166.30 skin:115.20
GeneChip cerebrum:6.86 cerebellum:6.73 brain stem:6.99 corpus callosum/glia:6.71 pineal gland:- peripheral nerve:6.96 spine:6.84 retina:- eye:- artery/aorta:6.82 vein:6.89 lymphnode:7.22 peripheral blood:- spleen:7.19 thymus:7.24 bone marrow:6.99 adipose:6.93 bone:- skin:6.83
CAGE cerebrum:2.61 cerebellum:- brain stem:2.94 corpus callosum/glia:3.00 pineal gland:2.07 peripheral nerve:- spine:2.28 retina:- eye:- artery/aorta:2.26 vein:2.92 lymphnode:2.86 peripheral blood:- spleen:3.02 thymus:3.05 bone marrow:- adipose:2.76 bone:- skin:-
RNA-seq cerebrum:2.33 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:3.13 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:2.74 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:118.50 placenta:54.60 prostate:78.90 ovary:111.80 testis:121.10 heart:229.90 muscle:- esophagus:342.80 stomach:85 intestine:226.80 colon:110.20     liver/hepato:73.90        lung:78.20    bladder:376.80 kidney:114.40 pituitary:- thyroid/parathyroid:327.50 adrenal gland:203.10 pancreas:97.80 breast:27.90 salivary:328.40
GeneChip uterus:7.28 placenta:6.89 prostate:7.24 ovary:7.76 testis:7.09 heart:7.13 muscle:7.58 esophagus:7.04 stomach:7.29 intestine:7.26 colon:7.11 liver/hepato:7.18 lung:6.61 bladder:- kidney:7.03 pituitary:7 thyroid/parathyroid:6.86 adrenal gland:7.10 pancreas:7.09 breast:6.90 salivary:6.99
CAGE uterus:2.88 placenta:2.71 prostate:2.80 ovary:2.99 testis:2.84 heart:2.66 muscle:3.08 esophagus:2.80 stomach:- intestine:2.49 colon:2.48     liver/hepato:3.09    lung:2.31 bladder:2.69 kidney:2.89 pituitary:2.59 thyroid/parathyroid:2.52 adrenal gland:- pancreas:2.86 breast:1.68 salivary:3.15
RNA-seq uterus:- placenta:- prostate:3.56 ovary:3.83 testis:3.39 heart:3.37 muscle:3.27 esophagus:- stomach:- intestine:- colon:2.61     liver/hepato:3.26        lung:2.62    bladder:- kidney:3.83 pituitary:- thyroid/parathyroid:3.21 adrenal gland:3.35 pancreas:- breast:3.01 salivary:-

Gene Information

IDs

Refseq ID NM_024102
Gene ID 79084
Unigene ID Hs.204773
Probe set ID 201421_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000116455
GTEx ID ENSG00000116455

Orthologous Gene

Mouse[3]  NM_027432
Rat [0]  

Chromosomal Region

1p13.2  [111,982,512  -  111,991,998]

Gene Family (Interpro ID)

IPR001680  WD40 repeat
IPR019782  WD40 repeat 2
IPR019781  WD40 repeat, subgroup
IPR011046  WD40 repeat-like-containing domain
IPR017986  WD40-repeat-containing domain
IPR015943  WD40/YVTN repeat-like-containing domain

Link to Pubmed  (Pubmed ID)

8125298
8619474
9110174
11756452
12477932
12560496
12972618
14702039
15130578
15221005
15324660
15489334
15670829
16087681
16196087
16253997
16300736
16710414
16712789
16980624
17032745
17081983
17158748
17207965
17314511
17437848
17620599
17643375
17707232
18029348
18356297
18404153
18457437
18562274
18984161
19167051
19188445
19840198
20360068
20951943
21139048
21145461
21183687
21316606
21385873
21706016
21789256
21963094
22022581
22169276
22268729
22365833
22505724
22863883
23071334
23084401
23145110
23184937
23246001
23398456
23455924
23734213
24337577
24550385
24657165
24816145

Gene Ontology  (GO ID)

Biological Process

GO:0010467  gene expression
GO:0034660  ncRNA metabolic process
GO:0060770  negative regulation of epithelial cell proliferation involved in prostate gland development
GO:0008284  positive regulation of cell proliferation
GO:0006357  regulation of transcription from RNA polymerase II promoter
GO:0016070  RNA metabolic process
GO:0060528  secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development
GO:0000387  spliceosomal snRNP assembly

Cellular Component

GO:0005737  cytoplasm
GO:0005829  cytosol
GO:0005794  Golgi apparatus
GO:0005730  nucleolus
GO:0005634  nucleus

Molecular Function

GO:0030374  ligand-dependent nuclear receptor transcription coactivator activity
GO:0005515  protein binding