pleckstrin homology domain containing, family F (with FYVE domain) member 1

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Synonym

Phafin-1, MGC4090, APPD, Zinc finger FYVE domain-containing protein 15, Apoptosis-inducing protein, PH and FYVE domain-containing protein 1, PLEKHF1, ZFYVE15, LAPF, PH domain-containing family F member 1, PHAFIN1

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:14.20 cerebellum:- brain stem:- corpus callosum/glia:58.30 pineal gland:- peripheral nerve:- spine:- retina:- eye:11.80 artery/aorta:- vein:- lymphnode:20.20 peripheral blood:91.10 spleen:- thymus:- bone marrow:- adipose:80.70 bone:12.80 skin:-
GeneChip cerebrum:5.66 cerebellum:5.43 brain stem:5.73 corpus callosum/glia:5.84 pineal gland:- peripheral nerve:5.83 spine:5.77 retina:- eye:- artery/aorta:6.48 vein:6.51 lymphnode:6.31 peripheral blood:- spleen:6.41 thymus:6 bone marrow:5.60 adipose:6.23 bone:- skin:6.21
CAGE cerebrum:1.53 cerebellum:- brain stem:2.32 corpus callosum/glia:2.35 pineal gland:0.51 peripheral nerve:- spine:1.77 retina:- eye:- artery/aorta:2.56 vein:2.60 lymphnode:2.08 peripheral blood:- spleen:1.93 thymus:2.25 bone marrow:- adipose:2.88 bone:- skin:-
RNA-seq cerebrum:1.30 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:2.80 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:1.86 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:9.10 placenta:72.90 prostate:- ovary:74.50 testis:8.70 heart:25.50 muscle:40.20 esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:4.90    bladder:- kidney:10.40 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:55.80 salivary:-
GeneChip uterus:6.06 placenta:6.54 prostate:6.06 ovary:5.69 testis:5.51 heart:6.34 muscle:6.94 esophagus:6.69 stomach:5.95 intestine:6 colon:6.16 liver/hepato:6.09 lung:5.93 bladder:- kidney:5.46 pituitary:5.21 thyroid/parathyroid:5.47 adrenal gland:5.62 pancreas:5.52 breast:6.26 salivary:7.11
CAGE uterus:2.57 placenta:2.83 prostate:2.84 ovary:2.10 testis:1.75 heart:2.39 muscle:3.37 esophagus:2.50 stomach:- intestine:1.64 colon:2.10     liver/hepato:1.99    lung:1.86 bladder:2.63 kidney:1.26 pituitary:0.50 thyroid/parathyroid:1.83 adrenal gland:- pancreas:1.74 breast:2.87 salivary:2.88
RNA-seq uterus:- placenta:- prostate:2.89 ovary:2.35 testis:2.27 heart:1.90 muscle:4.29 esophagus:- stomach:- intestine:- colon:1.74     liver/hepato:1.91        lung:2.21    bladder:- kidney:1.39 pituitary:- thyroid/parathyroid:2.49 adrenal gland:2.87 pancreas:- breast:2.74 salivary:-

Gene Information

IDs

Refseq ID NM_024310
Gene ID 79156
Unigene ID Hs.466383
Probe set ID 219566_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000166289
GTEx ID ENSG00000166289

Orthologous Gene

Mouse[1]  NM_024413
Rat[1]  NM_001013148

Chromosomal Region

19q12  [30,156,327  -  30,166,376]

Gene Family (Interpro ID)

IPR001849  Pleckstrin homology
IPR000306  Zinc finger, FYVE-type
IPR011011  Zinc finger, FYVE/PHD-type
IPR013083  Zinc finger, RING/FYVE/PHD-type

Link to Pubmed  (Pubmed ID)

12477932
14702039
15489334
16188880
16189514
18029348
21139048
22115783

Gene Ontology  (GO ID)

Biological Process

GO:0006915  apoptosis
GO:0007032  endosome organization
GO:0006917  induction of apoptosis
GO:0010508  positive regulation of autophagy
GO:0016050  vesicle organization

Cellular Component

GO:0005737  cytoplasm
GO:0005768  endosome
GO:0010008  endosome membrane
GO:0005765  lysosomal membrane
GO:0005764  lysosome
GO:0005730  nucleolus
GO:0005634  nucleus
GO:0048471  perinuclear region of cytoplasm

Molecular Function

GO:0046872  metal ion binding
GO:0032266  phosphatidylinositol 3-phosphate binding
GO:0070273  phosphatidylinositol-4-phosphate binding
GO:0010314  phosphatidylinositol-5-phosphate binding