NIMA (never in mitosis gene a)- related kinase 11

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Synonym

Serine/threonine-protein kinase Nek11, NimA-related protein kinase 11, NIMA (never in mitosis gene a)- related kinase 11, FLJ23495, NEK11, Never in mitosis A-related kinase 11

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST nodata
GeneChip nodata
CAGE cerebrum:2.26 cerebellum:- brain stem:2.08 corpus callosum/glia:2.90 pineal gland:1.85 peripheral nerve:- spine:2.55 retina:- eye:- artery/aorta:2.17 vein:1.49 lymphnode:1.33 peripheral blood:- spleen:1.24 thymus:0.80 bone marrow:- adipose:1.66 bone:- skin:-
RNA-seq cerebrum:0.19 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0.17 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.05 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST nodata
GeneChip nodata
CAGE uterus:2.24 placenta:2.09 prostate:1.86 ovary:2.56 testis:3.09 heart:1.36 muscle:0.67 esophagus:1.54 stomach:- intestine:1.13 colon:1.90     liver/hepato:0.84    lung:2.27 bladder:1.58 kidney:2.19 pituitary:2.75 thyroid/parathyroid:2.53 adrenal gland:- pancreas:1.42 breast:2.41 salivary:1.49
RNA-seq uterus:- placenta:- prostate:0 ovary:0.02 testis:1.83 heart:0.04 muscle:0 esophagus:- stomach:- intestine:- colon:0.00     liver/hepato:0.00        lung:0.34    bladder:- kidney:0.21 pituitary:- thyroid/parathyroid:0.05 adrenal gland:0.18 pancreas:- breast:0.00 salivary:-

Gene Information

IDs

Refseq ID NM_145910
Gene ID 79858
Unigene ID -
Probe set ID -
Ensembl ID ENSG00000114670
GTEx ID ENSG00000114670

Orthologous Gene

Mouse[1]  NM_172461
Rat[1]  NM_001108182

Chromosomal Region

3q22.1  [130,745,694  -  131,069,309]

Gene Family (Interpro ID)

IPR000719  Protein kinase, catalytic domain
IPR011009  Protein kinase-like domain
IPR002290  Serine/threonine-protein kinase domain
IPR017442  Serine/threonine-protein kinase-like domain
IPR001245  Tyrosine-protein kinase, catalytic domain
IPR020635  Tyrosine-protein kinase, subgroup, catalytic domain

Link to Pubmed  (Pubmed ID)

8889548
12154088
12477932
12742165
14702039
15161910
15489334
18029348
18519826
19734889
20090422
20379614
21832049
21988832
22939624

Gene Ontology  (GO ID)

Biological Process

GO:0007049  cell cycle
GO:0031572  G2/M transition DNA damage checkpoint
GO:0031573  intra-S DNA damage checkpoint
GO:0006468  protein amino acid phosphorylation
GO:0007243  protein kinase cascade

Cellular Component

GO:0005730  nucleolus
GO:0005634  nucleus

Molecular Function

GO:0005524  ATP binding
GO:0046872  metal ion binding
GO:0005515  protein binding
GO:0004674  protein serine/threonine kinase activity