ALX homeobox 1

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Synonym

CART1, cartilage paired-class homeoprotein 1, Cartilage homeoprotein 1, CART-1

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:- cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:14.40
GeneChip cerebrum:4.79 cerebellum:4.80 brain stem:4.81 corpus callosum/glia:4.72 pineal gland:- peripheral nerve:4.56 spine:4.58 retina:- eye:- artery/aorta:4.68 vein:4.68 lymphnode:4.50 peripheral blood:- spleen:4.43 thymus:4.40 bone marrow:4.67 adipose:4.72 bone:- skin:4.73
CAGE cerebrum:0.03 cerebellum:- brain stem:0.10 corpus callosum/glia:0 pineal gland:0 peripheral nerve:- spine:0 retina:- eye:- artery/aorta:0 vein:0 lymphnode:0 peripheral blood:- spleen:0 thymus:0 bone marrow:- adipose:0.63 bone:- skin:-
RNA-seq cerebrum:0 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.02 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:10.60        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip uterus:4.74 placenta:4.57 prostate:4.59 ovary:4.67 testis:4.72 heart:4.70 muscle:4.69 esophagus:4.52 stomach:4.62 intestine:4.65 colon:4.69 liver/hepato:4.67 lung:4.60 bladder:- kidney:5.08 pituitary:4.89 thyroid/parathyroid:4.58 adrenal gland:4.63 pancreas:5.05 breast:4.56 salivary:4.77
CAGE uterus:1.24 placenta:0.08 prostate:0.53 ovary:0.95 testis:0.32 heart:0.04 muscle:0.09 esophagus:0.09 stomach:- intestine:0 colon:0     liver/hepato:0    lung:0 bladder:0.73 kidney:1.24 pituitary:0.34 thyroid/parathyroid:0.12 adrenal gland:- pancreas:0 breast:1.16 salivary:0
RNA-seq uterus:- placenta:- prostate:0.65 ovary:0.13 testis:0.58 heart:0.01 muscle:0 esophagus:- stomach:- intestine:- colon:0     liver/hepato:0        lung:0    bladder:- kidney:1.39 pituitary:- thyroid/parathyroid:0.07 adrenal gland:0 pancreas:- breast:0.03 salivary:-

Gene Information

IDs

Refseq ID NM_006982
Gene ID 8092
Unigene ID Hs.41683
Probe set ID 206837_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000180318
GTEx ID ENSG00000180318

Orthologous Gene

Mouse[1]  NM_172553
Rat [0]  

Chromosomal Region

12q21.31  [85,673,885  -  85,695,562]

Gene Family (Interpro ID)

IPR001356  Homeobox
IPR009057  Homeodomain-like
IPR012287  Homeodomain-related

Link to Pubmed  (Pubmed ID)

7592751
7690966
8673125
8756334
9753625
9847249
12477932
12929931
15489334
16189514
18029348
18976975
20398657
20451171
20932315
23288509
24081945

Gene Ontology  (GO ID)

Biological Process

GO:0009952  anterior/posterior pattern formation
GO:0007420  brain development
GO:0001502  cartilage condensation
GO:0030326  embryonic limb morphogenesis
GO:0048704  embryonic skeletal system morphogenesis
GO:0014031  mesenchymal cell development
GO:0007275  multicellular organismal development
GO:0000122  negative regulation of transcription from RNA polymerase II promoter
GO:0001843  neural tube closure
GO:0060021  palate development
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0006366  transcription from RNA polymerase II promoter

Cellular Component

GO:0005634  nucleus
GO:0005667  transcription factor complex

Molecular Function

GO:0005515  protein binding
GO:0046982  protein heterodimerization activity
GO:0043565  sequence-specific DNA binding
GO:0003714  transcription corepressor activity
GO:0003700  transcription factor activity