calreticulin

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Synonym

grp60, FLJ26680, CRTC, CALR, calreticulin, Calreticulin precursor, RO, Calregulin, SSA, cC1qR, HACBP, CRP55

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:71.10 cerebellum:12.60 brain stem:- corpus callosum/glia:- pineal gland:296.70 peripheral nerve:184 spine:224.60 retina:355.90 eye:270.30 artery/aorta:179.90 vein:- lymphnode:535.90 peripheral blood:145.70 spleen:56.70 thymus:25.80 bone marrow:314.90 adipose:40.30 bone:179.10 skin:422.40
GeneChip cerebrum:7.66 cerebellum:7.21 brain stem:7.78 corpus callosum/glia:7.96 pineal gland:- peripheral nerve:7.86 spine:8.04 retina:- eye:- artery/aorta:8.42 vein:7.88 lymphnode:8.38 peripheral blood:- spleen:8.18 thymus:8.07 bone marrow:8.13 adipose:8.25 bone:- skin:7.98
CAGE cerebrum:5.94 cerebellum:- brain stem:5.96 corpus callosum/glia:6.29 pineal gland:6.24 peripheral nerve:- spine:5.90 retina:- eye:- artery/aorta:6.83 vein:6.38 lymphnode:6.80 peripheral blood:- spleen:6.69 thymus:6.44 bone marrow:- adipose:6.75 bone:- skin:-
RNA-seq cerebrum:6.49 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:8.15 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:8.09 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:346.30 placenta:313.30 prostate:473.10 ovary:372.60 testis:116.80 heart:485.30 muscle:- esophagus:- stomach:191.20 intestine:129.60 colon:313.70     liver/hepato:253.30        lung:415.40    bladder:- kidney:176.80 pituitary:- thyroid/parathyroid:- adrenal gland:50.80 pancreas:222.30 breast:631.90 salivary:-
GeneChip uterus:8.07 placenta:7.43 prostate:8.53 ovary:7.98 testis:8.10 heart:8.07 muscle:7.10 esophagus:8.33 stomach:8.20 intestine:7.64 colon:8 liver/hepato:8.72 lung:7.95 bladder:- kidney:8.38 pituitary:9.06 thyroid/parathyroid:9.58 adrenal gland:8.44 pancreas:7.68 breast:8.26 salivary:8.47
CAGE uterus:6.50 placenta:7.01 prostate:6.35 ovary:6.59 testis:6.57 heart:6.48 muscle:5.61 esophagus:6.30 stomach:- intestine:6.46 colon:6.43     liver/hepato:8.03    lung:6.61 bladder:6.19 kidney:6.86 pituitary:6.60 thyroid/parathyroid:7.95 adrenal gland:- pancreas:7.23 breast:6.73 salivary:7.16
RNA-seq uterus:- placenta:- prostate:7.88 ovary:8.52 testis:8.28 heart:6.66 muscle:6.92 esophagus:- stomach:- intestine:- colon:8.22     liver/hepato:9.84        lung:8.40    bladder:- kidney:8.72 pituitary:- thyroid/parathyroid:8.91 adrenal gland:8.54 pancreas:- breast:7.67 salivary:-

Gene Information

IDs

Refseq ID NM_004343
Gene ID 811
Unigene ID Hs.515162
Probe set ID 212953_x_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000179218
GTEx ID ENSG00000179218

Orthologous Gene

Mouse[6]  NM_007591
Rat [0]  

Chromosomal Region

19p13.2  [13,049,414  -  13,055,304]

Gene Family (Interpro ID)

IPR009169  Calreticulin
IPR001580  Calreticulin/calnexin

Link to Pubmed  (Pubmed ID)

1286667
1286669
1733953
1911778
1919005
1939344
2332496
2365822
2400400
3260607
7559457
7592883
7622522
7841019
7876246
7923996
8006073
8050453
8062452
8107808
8107809
8125298
8418194
8537405
8550632
8662691
8666824
8769474
8805302
8904349
8910335
9036970
9089287
9150948
9312001
9359841
9427624
9525969
9545232
9671507
9693955
9988700
10198260
10358038
10364189
10436013
10508608
10513896
10547375
10581245
10887119
10929008
11149926
11322874
11327697
11378243
11765911
11825569
11842004
11859136
11891802
12047747
12052826
12065601
12147682
12196561
12235131
12239218
12242300
12324449
12362238
12383251
12397072
12477932
12538033
12584332
12646570
12704787
12740382
12821648
14624761
14726956
14732231
14980518
14985176
15056662
15057824
15231747
15236594
15351734
15371419
15383281
15474971
15489334
15494401
15596044
15634883
15855281
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15952740
15998798
16130169
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16542777
16951181
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17215244
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17655857
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17982021
18022694
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18417548
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19199708
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19608864
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19684620
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20000738
20360068
20480531
20533543
20624402
20628086
20699648
20834237
20855873
20861015
20929309
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21652723
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24035512
24169561
24214877
24244333
24264800
24325356
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24365789
24366362
24371211
24421250
24457600
24480782
24553179
24583282
24593306
24639526
24764562
24816145

Gene Ontology  (GO ID)

Biological Process

GO:0006987  activation of signaling protein activity involved in unfolded protein response
GO:0042590  antigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0002479  antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0002474  antigen processing and presentation of peptide antigen via MHC class I
GO:0055007  cardiac muscle cell differentiation
GO:0007050  cell cycle arrest
GO:0006874  cellular calcium ion homeostasis
GO:0044267  cellular protein metabolic process
GO:0071285  cellular response to lithium ion
GO:0030866  cortical actin cytoskeleton organization
GO:0030968  endoplasmic reticulum unfolded protein response
GO:0042921  glucocorticoid receptor signaling pathway
GO:0045665  negative regulation of neuron differentiation
GO:0048387  negative regulation of retinoic acid receptor signaling pathway
GO:0033144  negative regulation of steroid hormone receptor signaling pathway
GO:0000122  negative regulation of transcription from RNA polymerase II promoter
GO:0045892  negative regulation of transcription, DNA-dependent
GO:0017148  negative regulation of translation
GO:0002502  peptide antigen assembly with MHC class I protein complex
GO:0045787  positive regulation of cell cycle
GO:0008284  positive regulation of cell proliferation
GO:0045740  positive regulation of DNA replication
GO:0010628  positive regulation of gene expression
GO:0050766  positive regulation of phagocytosis
GO:0043687  post-translational protein modification
GO:0018279  protein amino acid N-linked glycosylation via asparagine
GO:0006611  protein export from nucleus
GO:0006457  protein folding
GO:0034504  protein localization in nucleus
GO:0022417  protein maturation by protein folding
GO:0050821  protein stabilization
GO:0042981  regulation of apoptosis
GO:0040020  regulation of meiosis
GO:0006355  regulation of transcription, DNA-dependent
GO:0042493  response to drug
GO:0032355  response to estradiol stimulus
GO:0033574  response to testosterone stimulus
GO:0051208  sequestering of calcium ion
GO:0007283  spermatogenesis

Cellular Component

GO:0001669  acrosomal vesicle
GO:0009986  cell surface
GO:0005737  cytoplasm
GO:0005829  cytosol
GO:0005783  endoplasmic reticulum
GO:0005788  endoplasmic reticulum lumen
GO:0009897  external side of plasma membrane
GO:0005576  extracellular region
GO:0005615  extracellular space
GO:0005794  Golgi apparatus
GO:0005622  intracellular
GO:0042824  MHC class I peptide loading complex
GO:0005634  nucleus
GO:0048471  perinuclear region of cytoplasm
GO:0005844  polysome
GO:0005578  proteinaceous extracellular matrix
GO:0033018  sarcoplasmic reticulum lumen

Molecular Function

GO:0050681  androgen receptor binding
GO:0005509  calcium ion binding
GO:0030246  carbohydrate binding
GO:0051087  chaperone binding
GO:0001849  complement component C1q binding
GO:0003677  DNA binding
GO:0042562  hormone binding
GO:0005178  integrin binding
GO:0005506  iron ion binding
GO:0003729  mRNA binding
GO:0042277  peptide binding
GO:0005515  protein binding
GO:0044183  protein binding involved in protein folding
GO:0031625  ubiquitin protein ligase binding
GO:0051082  unfolded protein binding
GO:0008270  zinc ion binding