sphingosine-1-phosphate phosphatase 1

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Synonym

hSPPase1, Sphingosine-1-phosphate phosphatase 1, Sphingosine-1-phosphatase 1, sphingosine-1-phosphate phosphatase 1, SPPase1, SGPP1, Spp1

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:17.80 cerebellum:25.20 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:61.30 spine:- retina:118.60 eye:5.90 artery/aorta:- vein:- lymphnode:60.70 peripheral blood:- spleen:- thymus:12.90 bone marrow:- adipose:- bone:25.60 skin:4.80
GeneChip cerebrum:4.87 cerebellum:4.93 brain stem:4.76 corpus callosum/glia:5.07 pineal gland:- peripheral nerve:4.99 spine:5.68 retina:- eye:- artery/aorta:4.17 vein:3.91 lymphnode:4.42 peripheral blood:- spleen:5.22 thymus:5.44 bone marrow:4.03 adipose:4.44 bone:- skin:4.53
CAGE cerebrum:3.24 cerebellum:- brain stem:3.49 corpus callosum/glia:3.77 pineal gland:3.03 peripheral nerve:- spine:3.30 retina:- eye:- artery/aorta:2.89 vein:3.61 lymphnode:3.69 peripheral blood:- spleen:3.78 thymus:3.59 bone marrow:- adipose:3.41 bone:- skin:-
RNA-seq cerebrum:3.94 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:3.85 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:2.96 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:9.10 placenta:123.90 prostate:11.30 ovary:- testis:4.30 heart:- muscle:20.10 esophagus:- stomach:42.50 intestine:- colon:-     liver/hepato:52.80        lung:19.60    bladder:125.60 kidney:31.20 pituitary:- thyroid/parathyroid:- adrenal gland:50.80 pancreas:80 breast:18.60 salivary:-
GeneChip uterus:5 placenta:7.60 prostate:5.31 ovary:4.23 testis:4.68 heart:4.18 muscle:3.66 esophagus:3.84 stomach:4.42 intestine:4.63 colon:4.28 liver/hepato:4.28 lung:3.96 bladder:- kidney:5.05 pituitary:4.45 thyroid/parathyroid:4.19 adrenal gland:4.17 pancreas:5.11 breast:4.28 salivary:4.17
CAGE uterus:3.19 placenta:4.80 prostate:3.15 ovary:3.07 testis:3.29 heart:2.61 muscle:2.23 esophagus:2.88 stomach:- intestine:2.92 colon:2.86     liver/hepato:4.19    lung:3.26 bladder:2.99 kidney:3.88 pituitary:2.88 thyroid/parathyroid:2.87 adrenal gland:- pancreas:3.47 breast:3.06 salivary:2.93
RNA-seq uterus:- placenta:- prostate:3.14 ovary:3.45 testis:3.51 heart:1.96 muscle:1.53 esophagus:- stomach:- intestine:- colon:2.86     liver/hepato:4.18        lung:3.19    bladder:- kidney:4.77 pituitary:- thyroid/parathyroid:3.09 adrenal gland:3.46 pancreas:- breast:3.54 salivary:-

Gene Information

IDs

Refseq ID NM_030791
Gene ID 81537
Unigene ID Hs.24678
Probe set ID 221268_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000126821
GTEx ID ENSG00000126821

Orthologous Gene

Mouse[3]  NM_030750
Rat[3]  NM_030750

Chromosomal Region

14q23.2  [64,150,932  -  64,194,757]

Gene Family (Interpro ID)

IPR000326  Phosphatidic acid phosphatase type 2/haloperoxidase

Link to Pubmed  (Pubmed ID)

10859351
11069896
12411432
12477932
12508121
12815058
15180992
15489334
16782891
17081983
17895250
19322201
19798445
20798685
21940944
22052905
22106015
22359512
24145350
24816145

Gene Ontology  (GO ID)

Biological Process

GO:0006915  apoptosis
GO:0006668  sphinganine-1-phosphate metabolic process
GO:0030148  sphingolipid biosynthetic process
GO:0006665  sphingolipid metabolic process
GO:0006670  sphingosine metabolic process

Cellular Component

GO:0005789  endoplasmic reticulum membrane
GO:0016021  integral to membrane

Molecular Function

GO:0042392  sphingosine-1-phosphate phosphatase activity