lysine (K)-specific demethylase 5C

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Synonym

XE169, SMCX, MRXJ, JARID1C, MRXSJ, Protein Xe169, Protein SmcX, jumonji, AT rich interactive domain 1C, Jumonji/ARID domain-containing protein 1C, DXS1272E

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:74.70 cerebellum:239.30 brain stem:- corpus callosum/glia:29.20 pineal gland:- peripheral nerve:61.30 spine:224.60 retina:237.30 eye:64.60 artery/aorta:- vein:- lymphnode:60.70 peripheral blood:54.70 spleen:- thymus:103.10 bone marrow:98.40 adipose:- bone:12.80 skin:52.80
GeneChip cerebrum:7.44 cerebellum:7.70 brain stem:7.34 corpus callosum/glia:7.44 pineal gland:- peripheral nerve:7.25 spine:7.31 retina:- eye:- artery/aorta:7.30 vein:7.26 lymphnode:7.64 peripheral blood:- spleen:7.48 thymus:7.34 bone marrow:7.48 adipose:7.56 bone:- skin:7.37
CAGE cerebrum:3.73 cerebellum:- brain stem:3.73 corpus callosum/glia:3.84 pineal gland:4.11 peripheral nerve:- spine:3.50 retina:- eye:- artery/aorta:3.59 vein:3.39 lymphnode:3.32 peripheral blood:- spleen:3.44 thymus:3.86 bone marrow:- adipose:3.66 bone:- skin:-
RNA-seq cerebrum:1.09 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:2.37 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.57 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:72.90 placenta:54.60 prostate:78.90 ovary:37.30 testis:51.90 heart:12.80 muscle:40.20 esophagus:- stomach:42.50 intestine:32.40 colon:59.40     liver/hepato:21.10        lung:39.10    bladder:- kidney:31.20 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:44.50 breast:83.60 salivary:-
GeneChip uterus:7.49 placenta:7.91 prostate:7 ovary:7.39 testis:6.97 heart:7.51 muscle:7.22 esophagus:7.49 stomach:7.43 intestine:7.32 colon:7.65 liver/hepato:7.52 lung:7.29 bladder:- kidney:7.52 pituitary:7.89 thyroid/parathyroid:7.29 adrenal gland:7.61 pancreas:7.86 breast:7.58 salivary:7.50
CAGE uterus:3.95 placenta:4.14 prostate:3.41 ovary:3.92 testis:3.27 heart:3.03 muscle:3.47 esophagus:3.74 stomach:- intestine:3.78 colon:3.46     liver/hepato:3.35    lung:3.41 bladder:3.73 kidney:3.50 pituitary:4.05 thyroid/parathyroid:3.60 adrenal gland:- pancreas:3.42 breast:3.43 salivary:3.38
RNA-seq uterus:- placenta:- prostate:1.84 ovary:1.21 testis:0.83 heart:0.77 muscle:1.66 esophagus:- stomach:- intestine:- colon:0.56     liver/hepato:0.25        lung:1.18    bladder:- kidney:1.21 pituitary:- thyroid/parathyroid:1.48 adrenal gland:0.72 pancreas:- breast:0.54 salivary:-

Gene Information

IDs

Refseq ID NM_001146702
Gene ID 8242
Unigene ID Hs.631768
Probe set ID 202383_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000126012
GTEx ID ENSG00000126012

Orthologous Gene

Mouse[2]  NM_013668
Rat[2]  NM_013668

Chromosomal Region

Xp11.22  [53,220,503  -  53,254,604]

Gene Family (Interpro ID)

IPR003347  Transcription factor jumonji/aspartyl beta-hydroxylase
IPR019787  Zinc finger, PHD-finger
IPR001965  Zinc finger, PHD-type

Link to Pubmed  (Pubmed ID)

7951230
8162017
12477932
14660691
15302935
15586325
15772651
15840729
16344560
16538222
16541399
16964243
17081983
17320160
17320161
17468742
18078810
18697827
19346402
19826449
20054297
20538609
21139048
21252943
21575681
21725364
21890473
21963094
21996408
22326837
22611640
22939629
23246292
23356856
24029645
24250222

Gene Ontology  (GO ID)

Biological Process

GO:0034720  histone H3-K4 demethylation
GO:0006355  regulation of transcription, DNA-dependent
GO:0006351  transcription, DNA-dependent

Cellular Component

GO:0005634  nucleus

Molecular Function

GO:0003677  DNA binding
GO:0032453  histone demethylase activity (H3-K4 specific)
GO:0016706  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
GO:0016702  oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
GO:0008270  zinc ion binding