calpain 3, (p94)

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Synonym

CANP3, Calpain-3, MGC14344, CAPN3, Calpain p94, LGMD2, MGC10767, CANPL3, MGC11121, calpain 3, (p94), MGC4403, Calcium-activated neutral proteinase 3, LGMD2A, NCL1, nCL-1, Calpain L3, CANP 3

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:79.40 cerebellum:12.60 brain stem:- corpus callosum/glia:29.20 pineal gland:- peripheral nerve:61.30 spine:- retina:118.60 eye:64.60 artery/aorta:30 vein:66.60 lymphnode:80.90 peripheral blood:91.10 spleen:37.80 thymus:12.90 bone marrow:295.20 adipose:282.30 bone:12.80 skin:163.20
GeneChip cerebrum:8.45 cerebellum:6.55 brain stem:8.97 corpus callosum/glia:9.47 pineal gland:- peripheral nerve:6.43 spine:9.13 retina:- eye:- artery/aorta:6.30 vein:5.87 lymphnode:6.74 peripheral blood:- spleen:6.61 thymus:6.21 bone marrow:7.45 adipose:5.96 bone:- skin:7.03
CAGE cerebrum:4.42 cerebellum:- brain stem:5.53 corpus callosum/glia:5.90 pineal gland:1.90 peripheral nerve:- spine:5.56 retina:- eye:- artery/aorta:0.47 vein:2.31 lymphnode:1.71 peripheral blood:- spleen:0.17 thymus:0.50 bone marrow:- adipose:3.55 bone:- skin:-
RNA-seq cerebrum:0 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0.54 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.02 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:27.30 placenta:40.10 prostate:11.30 ovary:74.50 testis:95.20 heart:38.30 muscle:743.30 esophagus:- stomach:21.20 intestine:97.20 colon:84.80     liver/hepato:63.30        lung:48.90    bladder:- kidney:52 pituitary:- thyroid/parathyroid:- adrenal gland:50.80 pancreas:8.90 breast:37.20 salivary:-
GeneChip uterus:5.97 placenta:4.56 prostate:5.88 ovary:5.77 testis:7.77 heart:5.46 muscle:10.25 esophagus:7.15 stomach:5.52 intestine:6.14 colon:5.30 liver/hepato:6.91 lung:7.06 bladder:- kidney:7.59 pituitary:5.93 thyroid/parathyroid:5.89 adrenal gland:5.96 pancreas:4.93 breast:6.45 salivary:5.64
CAGE uterus:0.35 placenta:0.59 prostate:0.53 ovary:0.79 testis:3.15 heart:1.43 muscle:6.28 esophagus:1.59 stomach:- intestine:0.14 colon:0     liver/hepato:0    lung:1.28 bladder:0.33 kidney:3.06 pituitary:0.26 thyroid/parathyroid:1.45 adrenal gland:- pancreas:0 breast:0 salivary:1.58
RNA-seq uterus:- placenta:- prostate:0.00 ovary:0.65 testis:0.21 heart:0 muscle:0 esophagus:- stomach:- intestine:- colon:0.00     liver/hepato:0        lung:0.32    bladder:- kidney:0.27 pituitary:- thyroid/parathyroid:0.05 adrenal gland:0.28 pancreas:- breast:0 salivary:-

Gene Information

IDs

Refseq ID NM_173087
Gene ID 825
Unigene ID Hs.143261
Probe set ID 210944_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000092529
GTEx ID ENSG00000092529

Orthologous Gene

Mouse[2]  NM_001109761, NM_001177799, NM_007601
Rat [0]  

Chromosomal Region

15q15.1  [42,640,301  -  42,704,515]

Gene Family (Interpro ID)

IPR002048  Calcium-binding EF-hand
IPR018249  EF-HAND 2

Link to Pubmed  (Pubmed ID)

2209092
2555341
7720071
8537379
8624690
8954122
9150160
9185618
9246005
9266733
9396712
9642272
9655129
9762961
9763216
9771675
9873017
10068445
10229226
10330340
10987085
11485017
12075569
12461690
12477932
12482600
12882647
14506720
14583192
14675785
14702039
14981715
15073171
15221789
15324660
15351423
15489334
15689361
15725583
15827562
16107503
16141003
16189514
16290124
16533054
16627476
16934440
16971480
17157502
17318636
17585039
17596655
17702496
17897354
17979987
18073330
18258189
18299526
18310072
18334579
18337726
18563459
18676612
18854869
18974005
19048948
19074885
19386580
19460752
19556129
20139084
20301490
20301582
20477750
20517216
20533264
20634290
20635405
20686565
20860623
21172462
21204801
21386772
21836041
21984748
22006685
22158424
22443334
22486197
22505582
22926650
22975586
23666804
23707407
23821418
23908349
24097068
24126726

Gene Ontology  (GO ID)

Biological Process

GO:0006915  apoptosis
GO:0001896  autolysis
GO:0071277  cellular response to calcium ion
GO:0071472  cellular response to salt stress
GO:0070315  G1 to G0 transition involved in cell differentiation
GO:0046716  muscle homeostasis
GO:0007517  muscle organ development
GO:0030239  myofibril assembly
GO:0043066  negative regulation of apoptosis
GO:0033234  negative regulation of protein sumoylation
GO:0045892  negative regulation of transcription, DNA-dependent
GO:0051092  positive regulation of NF-kappaB transcription factor activity
GO:0045862  positive regulation of proteolysis
GO:0051281  positive regulation of release of sequestered calcium ion into cytosol
GO:0014718  positive regulation of satellite cell activation involved in skeletal muscle regeneration
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0006461  protein complex assembly
GO:0006508  proteolysis
GO:0050790  regulation of catalytic activity
GO:0043122  regulation of I-kappaB kinase/NF-kappaB cascade
GO:0045661  regulation of myoblast differentiation
GO:0051592  response to calcium ion
GO:0014850  response to muscle activity
GO:0045214  sarcomere organization
GO:0007165  signal transduction

Cellular Component

GO:0005737  cytoplasm
GO:0005829  cytosol
GO:0005622  intracellular
GO:0030016  myofibril
GO:0005634  nucleus
GO:0005886  plasma membrane
GO:0043234  protein complex
GO:0030315  T-tubule
GO:0030018  Z disc

Molecular Function

GO:0005509  calcium ion binding
GO:0004198  calcium-dependent cysteine-type endopeptidase activity
GO:0003824  catalytic activity
GO:0008234  cysteine-type peptidase activity
GO:0055103  ligase regulator activity
GO:0008233  peptidase activity
GO:0005515  protein binding
GO:0032947  protein complex scaffold
GO:0004871  signal transducer activity
GO:0031402  sodium ion binding
GO:0008307  structural constituent of muscle
GO:0031432  titin binding