frizzled homolog 1 (Drosophila)

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Synonym

frizzled homolog 1 (Drosophila), FZD1, FzE1, Fz-1, frizzled (Drosophila) homolog 1, hFz1, Frizzled-1 precursor

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST nodata
GeneChip cerebrum:5.09 cerebellum:5.97 brain stem:5.02 corpus callosum/glia:5.27 pineal gland:- peripheral nerve:7.74 spine:5.56 retina:- eye:- artery/aorta:6.99 vein:6.88 lymphnode:5.27 peripheral blood:- spleen:5.26 thymus:5.60 bone marrow:5.20 adipose:5.90 bone:- skin:6.64
CAGE cerebrum:1.60 cerebellum:- brain stem:1.20 corpus callosum/glia:1.95 pineal gland:0.97 peripheral nerve:- spine:1.92 retina:- eye:- artery/aorta:3.67 vein:1.89 lymphnode:1.25 peripheral blood:- spleen:1.76 thymus:0.96 bone marrow:- adipose:2.17 bone:- skin:-
RNA-seq cerebrum:1.08 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:2.58 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:2.36 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST nodata
GeneChip uterus:7.25 placenta:7.36 prostate:7.67 ovary:7.11 testis:4.96 heart:6.53 muscle:5.22 esophagus:6.04 stomach:6.26 intestine:6.55 colon:6.73 liver/hepato:5.24 lung:6.91 bladder:- kidney:6.95 pituitary:5.59 thyroid/parathyroid:9.07 adrenal gland:6.63 pancreas:5.36 breast:7.21 salivary:6.30
CAGE uterus:2.85 placenta:2.64 prostate:2.95 ovary:3.09 testis:1.99 heart:2.52 muscle:1.09 esophagus:2.48 stomach:- intestine:2.51 colon:2.49     liver/hepato:1.74    lung:2.76 bladder:2.74 kidney:3.03 pituitary:1.63 thyroid/parathyroid:4.37 adrenal gland:- pancreas:2.34 breast:2.47 salivary:2.17
RNA-seq uterus:- placenta:- prostate:3.29 ovary:4.10 testis:4.01 heart:2.88 muscle:1.29 esophagus:- stomach:- intestine:- colon:3.13     liver/hepato:0.98        lung:3.10    bladder:- kidney:3.62 pituitary:- thyroid/parathyroid:5.49 adrenal gland:2.57 pancreas:- breast:3.07 salivary:-

Gene Information

IDs

Refseq ID NM_003505
Gene ID 8321
Unigene ID -
Probe set ID 204451_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000157240
GTEx ID ENSG00000157240

Orthologous Gene

Mouse[1]  NM_021457
Rat [0]  

Chromosomal Region

7q21.13  [90,893,783  -  90,898,123]

Gene Family (Interpro ID)

IPR000539  Frizzled protein
IPR020067  Frizzled-like domain
IPR017981  GPCR, family 2-like

Link to Pubmed  (Pubmed ID)

9707618
9813155
10557084
12012019
12067714
12477932
12690205
12853948
14739301
15252441
15370539
15489334
16442268
17496152
17895994
18382662
18715140
18929644
19148501
19188438
19277043
19388021
19421142
19453261
19543507
19643732
20051274
20634891
21906983
22303445
22484497
22505724
22939629
23259602
23442549
23806799

Gene Ontology  (GO ID)

Biological Process

GO:0007409  axonogenesis
GO:0007420  brain development
GO:0007267  cell-cell signaling
GO:0009790  embryonic development
GO:0030855  epithelial cell differentiation
GO:0007199  G-protein signaling, coupled to cGMP nucleotide second messenger
GO:0008406  gonad development
GO:0060022  hard palate development
GO:0048286  lung alveolus development
GO:0003149  membranous septum morphogenesis
GO:0003150  muscular septum morphogenesis
GO:0030514  negative regulation of BMP signaling pathway
GO:0045892  negative regulation of transcription, DNA-dependent
GO:0090090  negative regulation of Wnt receptor signaling pathway through beta-catenin
GO:0030182  neuron differentiation
GO:0003151  outflow tract morphogenesis
GO:0090179  planar cell polarity pathway involved in neural tube closure
GO:0001934  positive regulation of protein amino acid phosphorylation
GO:0051091  positive regulation of transcription factor activity
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0042493  response to drug
GO:0001944  vasculature development
GO:0060070  Wnt receptor signaling pathway through beta-catenin
GO:0007223  Wnt receptor signaling pathway, calcium modulating pathway

Cellular Component

GO:0045177  apical part of cell
GO:0009986  cell surface
GO:0005737  cytoplasm
GO:0016021  integral to membrane
GO:0032589  neuron projection membrane

Molecular Function

GO:0004930  G-protein coupled receptor activity
GO:0030165  PDZ domain binding
GO:0005515  protein binding
GO:0005102  receptor binding
GO:0042813  Wnt receptor activity
GO:0017147  Wnt-protein binding