frizzled homolog 4 (Drosophila)

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Synonym

Frizzled-4 precursor, FZD4S, frizzled homolog 4 (Drosophila), FzE4, frizzled (Drosophila) homolog 4, exudative vitreoretinopathy 1, EVR1, MGC34390, FZD4, hFz4, FEVR, Fz-4

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:17.80 cerebellum:12.60 brain stem:- corpus callosum/glia:29.20 pineal gland:- peripheral nerve:61.30 spine:- retina:- eye:23.50 artery/aorta:179.90 vein:66.60 lymphnode:- peripheral blood:- spleen:- thymus:12.90 bone marrow:19.70 adipose:201.70 bone:25.60 skin:14.40
GeneChip cerebrum:6.09 cerebellum:5.87 brain stem:5.97 corpus callosum/glia:5.85 pineal gland:- peripheral nerve:6.64 spine:5.97 retina:- eye:- artery/aorta:7.78 vein:7.33 lymphnode:6.41 peripheral blood:- spleen:7.16 thymus:5.79 bone marrow:6.04 adipose:8.78 bone:- skin:7.23
CAGE cerebrum:3.09 cerebellum:- brain stem:2.70 corpus callosum/glia:2.54 pineal gland:2.13 peripheral nerve:- spine:2.81 retina:- eye:- artery/aorta:5.04 vein:4.89 lymphnode:3.12 peripheral blood:- spleen:3.35 thymus:1.85 bone marrow:- adipose:6.04 bone:- skin:-
RNA-seq cerebrum:1.99 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:3.85 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:5.97 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:82 placenta:14.60 prostate:56.30 ovary:- testis:- heart:76.60 muscle:- esophagus:- stomach:- intestine:32.40 colon:237.40     liver/hepato:31.70        lung:44    bladder:125.60 kidney:124.80 pituitary:- thyroid/parathyroid:- adrenal gland:50.80 pancreas:35.60 breast:18.60 salivary:-
GeneChip uterus:6.88 placenta:6.32 prostate:7.18 ovary:7.26 testis:6.34 heart:7.65 muscle:7.43 esophagus:6.66 stomach:7.21 intestine:6.80 colon:6.98 liver/hepato:7.29 lung:7.68 bladder:- kidney:7.77 pituitary:6.91 thyroid/parathyroid:7.17 adrenal gland:7.42 pancreas:6.52 breast:7.37 salivary:6.83
CAGE uterus:4.34 placenta:3.20 prostate:4.06 ovary:4.27 testis:3.61 heart:4.63 muscle:4.27 esophagus:3.63 stomach:- intestine:2.56 colon:3.90     liver/hepato:3.65    lung:4.42 bladder:3.91 kidney:4.06 pituitary:3.88 thyroid/parathyroid:3.72 adrenal gland:- pancreas:3.47 breast:5.80 salivary:3.82
RNA-seq uterus:- placenta:- prostate:3.34 ovary:3.80 testis:2.85 heart:3.72 muscle:2.44 esophagus:- stomach:- intestine:- colon:3.76     liver/hepato:2.78        lung:4.20    bladder:- kidney:3.77 pituitary:- thyroid/parathyroid:3.81 adrenal gland:3.99 pancreas:- breast:6.43 salivary:-

Gene Information

IDs

Refseq ID NM_012193
Gene ID 8322
Unigene ID Hs.591968
Probe set ID 218665_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000174804
GTEx ID ENSG00000174804

Orthologous Gene

Mouse[2]  NM_008055
Rat[1]  NM_022623

Chromosomal Region

11q14.2  [86,656,721  -  86,666,433]

Gene Family (Interpro ID)

IPR000539  Frizzled protein
IPR020067  Frizzled-like domain
IPR017981  GPCR, family 2-like

Link to Pubmed  (Pubmed ID)

1598965
9707618
10544037
11401527
12044878
12067714
12172548
12477932
12958364
14507768
14688793
14737064
15024691
15035989
15195140
15223780
15370539
15488808
15489334
15981244
17093393
17386109
17955262
18156211
18161623
18787502
18976975
19020754
19172507
19277043
19388021
19453261
19643732
20008721
20141357
20301326
20340138
20634891
20713528
20819778
20938005
21097938
21363911
21900206
22057916
22574936
22575959
23077402
23441120
24250222
24816145

Gene Ontology  (GO ID)

Biological Process

GO:0007420  brain development
GO:0071300  cellular response to retinoic acid
GO:0009790  embryonic development
GO:0031987  locomotion involved in locomotory behavior
GO:0010812  negative regulation of cell-substrate adhesion
GO:0030182  neuron differentiation
GO:0043507  positive regulation of JUN kinase activity
GO:0051091  positive regulation of transcription factor activity
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0042701  progesterone secretion
GO:0030947  regulation of vascular endothelial growth factor receptor signaling pathway
GO:0007605  sensory perception of sound
GO:0034446  substrate adhesion-dependent cell spreading
GO:0001570  vasculogenesis
GO:0016055  Wnt receptor signaling pathway
GO:0060070  Wnt receptor signaling pathway through beta-catenin
GO:0007223  Wnt receptor signaling pathway, calcium modulating pathway

Cellular Component

GO:0042995  cell projection
GO:0009986  cell surface
GO:0005911  cell-cell junction
GO:0005737  cytoplasm
GO:0005887  integral to plasma membrane
GO:0005886  plasma membrane

Molecular Function

GO:0019955  cytokine binding
GO:0004930  G-protein coupled receptor activity
GO:0030165  PDZ domain binding
GO:0005515  protein binding
GO:0046982  protein heterodimerization activity
GO:0042803  protein homodimerization activity
GO:0031625  ubiquitin protein ligase binding
GO:0042813  Wnt receptor activity
GO:0017147  Wnt-protein binding