caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)

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Synonym

IL1BCE, Interleukin-1 beta convertase, P45, beta, IL-1BC, Interleukin-1 beta-converting enzyme, Caspase-1 precursor, IL1BC, CASP1, IL-1 beta-converting enzyme, CASP-1, ICE

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:3.60 cerebellum:12.60 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:112.30 retina:- eye:- artery/aorta:30 vein:- lymphnode:70.80 peripheral blood:72.90 spleen:94.50 thymus:25.80 bone marrow:19.70 adipose:- bone:64 skin:48
GeneChip cerebrum:3.84 cerebellum:3.73 brain stem:4.07 corpus callosum/glia:4.33 pineal gland:- peripheral nerve:4.68 spine:4.46 retina:- eye:- artery/aorta:4.84 vein:4.35 lymphnode:6.34 peripheral blood:- spleen:7.29 thymus:5.81 bone marrow:5.87 adipose:5.50 bone:- skin:5.61
CAGE cerebrum:1.27 cerebellum:- brain stem:1.65 corpus callosum/glia:0.66 pineal gland:1.53 peripheral nerve:- spine:2.58 retina:- eye:- artery/aorta:1.43 vein:1.53 lymphnode:2.01 peripheral blood:- spleen:2.51 thymus:1.14 bone marrow:- adipose:1.74 bone:- skin:-
RNA-seq cerebrum:1.38 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:3.99 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:2.66 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:18.20 placenta:25.50 prostate:11.30 ovary:- testis:- heart:25.50 muscle:- esophagus:342.80 stomach:85 intestine:162 colon:33.90     liver/hepato:-        lung:29.30    bladder:125.60 kidney:20.80 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip uterus:4.78 placenta:5.49 prostate:4.99 ovary:5.01 testis:3.35 heart:4.54 muscle:3.50 esophagus:5.65 stomach:5.56 intestine:6.03 colon:6.70 liver/hepato:4.70 lung:7.15 bladder:- kidney:3.88 pituitary:3.68 thyroid/parathyroid:4.10 adrenal gland:4.29 pancreas:3.39 breast:5.35 salivary:4.56
CAGE uterus:0.84 placenta:1.80 prostate:1.36 ovary:1.00 testis:0.54 heart:1.38 muscle:0.42 esophagus:1.52 stomach:- intestine:3.11 colon:2.18     liver/hepato:0.90    lung:2.46 bladder:1.24 kidney:0.74 pituitary:1.24 thyroid/parathyroid:0.82 adrenal gland:- pancreas:0.58 breast:1.80 salivary:1.00
RNA-seq uterus:- placenta:- prostate:3.12 ovary:3.08 testis:1.88 heart:1.84 muscle:0.57 esophagus:- stomach:- intestine:- colon:3.30     liver/hepato:0.81        lung:5.02    bladder:- kidney:1.85 pituitary:- thyroid/parathyroid:1.31 adrenal gland:3.63 pancreas:- breast:3.17 salivary:-

Gene Information

IDs

Refseq ID NM_033292
Gene ID 834
Unigene ID Hs.2490
Probe set ID 211368_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000137752
GTEx ID ENSG00000137752

Orthologous Gene

Mouse[1]  NM_009807
Rat [0]  

Chromosomal Region

11q22.3  [104,896,170  -  104,972,158]

Gene Family (Interpro ID)

IPR001315  Caspase Recruitment
IPR017350  Caspase, interleukin-1 beta convertase
IPR011029  DEATH-like
IPR011600  Peptidase C14, caspase catalytic
IPR002398  Peptidase C14, caspase precursor p45
IPR015917  Peptidase C14, caspase precursor p45, core

Link to Pubmed  (Pubmed ID)

1321594
1373520
1574116
1919001
7642516
7721861
7797510
7876192
8034320
8035875
8044845
8125298
8861900
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8978814
8999548
9002959
9070648
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9250871
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9535906
9548463
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10069390
10329646
10353249
10438581
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20060974
20170165
20184726
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20402676
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23637985
23703390
23793845
23839215
23884363
24022484
24130483
24356306
24481253

Gene Ontology  (GO ID)

Biological Process

GO:0006919  activation of caspase activity
GO:0006915  apoptosis
GO:0071260  cellular response to mechanical stimulus
GO:0071310  cellular response to organic substance
GO:0006917  induction of apoptosis
GO:0045087  innate immune response
GO:0032611  interleukin-1 beta production
GO:0060081  membrane hyperpolarization
GO:0051882  mitochondrial depolarization
GO:0043123  positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0050717  positive regulation of interleukin-1 alpha secretion
GO:0050718  positive regulation of interleukin-1 beta secretion
GO:0016485  protein processing
GO:0006508  proteolysis
GO:0033198  response to ATP
GO:0001666  response to hypoxia
GO:0007165  signal transduction

Cellular Component

GO:0005829  cytosol
GO:0005576  extracellular region

Molecular Function

GO:0008656  caspase activator activity
GO:0004197  cysteine-type endopeptidase activity
GO:0005515  protein binding