caspase 2, apoptosis-related cysteine peptidase

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Synonym

CASP2, ICH1, CASP-2, NEDD2, ICH-1L, ICH-1 protease, Caspase-2 precursor, ICH-1L/1S

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:27.30

cerebellum:63

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:61.30

spine:-

retina:-

eye:70.50

artery/aorta:-

vein:66.60

lymphnode:171.90

peripheral blood:18.20

spleen:18.90

thymus:141.70

bone marrow:19.70

adipose:40.30

bone:12.80

skin:57.60

GeneChip

cerebrum:3.25

cerebellum:3.22

brain stem:3.24

corpus callosum/glia:3.30

pineal gland:-

peripheral nerve:3.41

spine:3.38

retina:-

eye:-

artery/aorta:3.28

vein:3.24

lymphnode:3.45

peripheral blood:-

spleen:3.46

thymus:4.18

bone marrow:3.63

adipose:3.26

bone:-

skin:3.28

CAGE

cerebrum:1.83

cerebellum:-

brain stem:1.97

corpus callosum/glia:2.19

pineal gland:1.92

peripheral nerve:-

spine:1.53

retina:-

eye:-

artery/aorta:1.85

vein:2.57

lymphnode:2.63

peripheral blood:-

spleen:2.61

thymus:3.53

bone marrow:-

adipose:2.33

bone:-

skin:-

RNA-seq

cerebrum:0.72

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:0.00

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:1.87

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:54.70

placenta:54.60

prostate:56.30

ovary:74.50

testis:43.30

heart:51.10

muscle:-

esophagus:-

stomach:21.20

intestine:32.40

colon:67.80

liver/hepato:31.70

lung:9.80

bladder:125.60

kidney:31.20

pituitary:-

thyroid/parathyroid:-

adrenal gland:-

pancreas:-

breast:46.50

salivary:-

GeneChip

uterus:3.35

placenta:3.35

prostate:3.21

ovary:3.24

testis:3.26

heart:3.22

muscle:3.26

esophagus:3.39

stomach:3.22

intestine:3.27

colon:3.45

liver/hepato:3.21

lung:3.26

bladder:-

kidney:3.19

pituitary:3.38

thyroid/parathyroid:3.32

adrenal gland:3.18

pancreas:3.36

breast:3.28

salivary:3.35

CAGE

uterus:2.31

placenta:2.27

prostate:2.08

ovary:2.07

testis:2.33

heart:1.73

muscle:1.37

esophagus:2.31

stomach:-

intestine:1.94

colon:2.21

liver/hepato:1.29

lung:1.93

bladder:1.80

kidney:1.69

pituitary:1.81

thyroid/parathyroid:2.09

adrenal gland:-

pancreas:1.87

breast:1.80

salivary:2.22

RNA-seq

uterus:-

placenta:-

prostate:2.22

ovary:2.58

testis:2.28

heart:0.42

muscle:0.09

esophagus:-

stomach:-

intestine:-

colon:0.61

liver/hepato:0.00

lung:0.00

bladder:-

kidney:1.26

pituitary:-

thyroid/parathyroid:1.61

adrenal gland:1.22

pancreas:-

breast:1.28

salivary:-

IDs

Refseq ID	NM_032982
Gene ID	835
Unigene ID	Hs.368982
Probe set ID	34449_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000106144
GTEx ID	ENSG00000106144

Orthologous Gene

Mouse[2]	NM_007610
Rat [0]

Chromosomal Region

7q34 [142,985,308 - 143,004,789]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

IPR001315	Caspase Recruitment
IPR017350	Caspase, interleukin-1 beta convertase
IPR011029	DEATH-like
IPR011600	Peptidase C14, caspase catalytic
IPR002398	Peptidase C14, caspase precursor p45
IPR015917	Peptidase C14, caspase precursor p45, core

Gene Ontology (GO ID)

Biological Process

GO:0007568	aging
GO:0006915	apoptosis
GO:0007420	brain development
GO:0071260	cellular response to mechanical stimulus
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0006917	induction of apoptosis
GO:0001554	luteolysis
GO:0048011	nerve growth factor receptor signaling pathway
GO:0003407	neural retina development
GO:0043065	positive regulation of apoptosis
GO:0043525	positive regulation of neuron apoptosis
GO:0016485	protein processing
GO:0006508	proteolysis
GO:0043281	regulation of caspase activity

Cellular Component

GO:0005829	cytosol
GO:0016020	membrane
GO:0005739	mitochondrion
GO:0005634	nucleus

Molecular Function

GO:0004197	cysteine-type endopeptidase activity
GO:0019899	enzyme binding
GO:0005515	protein binding
GO:0019904	protein domain specific binding

caspase 2, apoptosis-related cysteine peptidase

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function