obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF

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Synonym

Obscurin-myosin light chain kinase, Obscurin-MLCK, UNC89, FLJ14124, DKFZp666E245, MGC120412, MGC120410, OBSCN, KIAA1639, Obscurin, Obscurin-RhoGEF, KIAA1556, MGC120411, MGC138590, MGC120409

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:- cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
GeneChip nodata
CAGE cerebrum:0.04 cerebellum:- brain stem:0.03 corpus callosum/glia:0.13 pineal gland:0 peripheral nerve:- spine:0.13 retina:- eye:- artery/aorta:0.18 vein:1.89 lymphnode:1.07 peripheral blood:- spleen:0 thymus:0 bone marrow:- adipose:1.88 bone:- skin:-
RNA-seq cerebrum:0.23 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0.51 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.07 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip nodata
CAGE uterus:0.09 placenta:0.08 prostate:0.21 ovary:0 testis:0.40 heart:3.81 muscle:5.80 esophagus:1.73 stomach:- intestine:0.57 colon:1.07     liver/hepato:0    lung:0.71 bladder:0.18 kidney:0 pituitary:0.32 thyroid/parathyroid:1.57 adrenal gland:- pancreas:0 breast:0 salivary:1.39
RNA-seq uterus:- placenta:- prostate:0.24 ovary:0.38 testis:0.99 heart:2.99 muscle:4.63 esophagus:- stomach:- intestine:- colon:0.18     liver/hepato:0.01        lung:0.29    bladder:- kidney:0.32 pituitary:- thyroid/parathyroid:3.18 adrenal gland:0.44 pancreas:- breast:0.71 salivary:-

Gene Information

IDs

Refseq ID NM_052843
Gene ID 84033
Unigene ID Hs.650039
Probe set ID -
Ensembl ID ENSG00000154358
GTEx ID ENSG00000154358

Orthologous Gene

Mouse [0]  
Rat [0]  

Chromosomal Region

1q42.13  [228,395,831  -  228,566,575]

Gene Family (Interpro ID)

IPR003961  Fibronectin, type III
IPR008957  Fibronectin, type III-like fold
IPR013106  Immunoglobulin V-set
IPR003596  Immunoglobulin V-set, subgroup
IPR001849  Pleckstrin homology
IPR000719  Protein kinase, catalytic domain
IPR011009  Protein kinase-like domain
IPR002290  Serine/threonine-protein kinase domain
IPR017442  Serine/threonine-protein kinase-like domain
IPR001245  Tyrosine-protein kinase, catalytic domain
IPR020635  Tyrosine-protein kinase, subgroup, catalytic domain

Link to Pubmed  (Pubmed ID)

10997877
11448995
11717165
11756498
11814696
12376548
12477932
12527750
12631729
12787561
14702039
15013951
15146197
15185077
15489334
16205939
16344560
16625316
16710414
16962094
17360660
17382936
17549794
17716621
17720975
18029348
18350308
18782775
19258391
20379614
20467438
20489725
22251166
22441987
22573887
23537643

Gene Ontology  (GO ID)

Biological Process

GO:0007275  multicellular organismal development
GO:0048011  nerve growth factor receptor signaling pathway
GO:0043065  positive regulation of apoptosis
GO:0035023  regulation of Rho protein signal transduction
GO:0051056  regulation of small GTPase mediated signal transduction
GO:0045214  sarcomere organization
GO:0007264  small GTPase mediated signal transduction

Cellular Component

GO:0005829  cytosol
GO:0031430  M band
GO:0030016  myofibril
GO:0030018  Z disc

Molecular Function

GO:0030506  ankyrin binding
GO:0005524  ATP binding
GO:0005516  calmodulin binding
GO:0046872  metal ion binding
GO:0005543  phospholipid binding
GO:0005515  protein binding
GO:0004674  protein serine/threonine kinase activity
GO:0004713  protein tyrosine kinase activity
GO:0005089  Rho guanyl-nucleotide exchange factor activity
GO:0008307  structural constituent of muscle
GO:0031432  titin binding