lysine (K)-specific demethylase 2B

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Synonym

Protein JEMMA, FBL10, CXXC2, JHDM1B, F-box protein FBL10, FBXL10, PCCX2, Fbl10, Protein-containing CXXC domain 2, CXXC-type zinc finger protein 2, F-box/LRR-repeat protein 10, F-box and leucine-rich repeat protein 10

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:55.70 cerebellum:37.80 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:153.40 spine:- retina:- eye:76.40 artery/aorta:- vein:- lymphnode:121.30 peripheral blood:18.20 spleen:- thymus:25.80 bone marrow:39.40 adipose:- bone:12.80 skin:57.60
GeneChip nodata
CAGE cerebrum:2.65 cerebellum:- brain stem:2.65 corpus callosum/glia:2.89 pineal gland:2.44 peripheral nerve:- spine:2.76 retina:- eye:- artery/aorta:2.59 vein:2.99 lymphnode:3.10 peripheral blood:- spleen:2.49 thymus:3.27 bone marrow:- adipose:2.25 bone:- skin:-
RNA-seq cerebrum:0.33 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:1.25 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.43 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:72.90 placenta:25.50 prostate:45.10 ovary:- testis:38.90 heart:38.30 muscle:- esophagus:- stomach:21.20 intestine:- colon:25.40     liver/hepato:-        lung:34.20    bladder:- kidney:72.80 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:8.90 breast:18.60 salivary:-
GeneChip nodata
CAGE uterus:2.29 placenta:2.31 prostate:2.11 ovary:1.87 testis:2.63 heart:2.00 muscle:1.05 esophagus:2.23 stomach:- intestine:2.12 colon:2.50     liver/hepato:1.54    lung:2.65 bladder:2.08 kidney:1.60 pituitary:2.10 thyroid/parathyroid:1.97 adrenal gland:- pancreas:2.54 breast:2.11 salivary:2.26
RNA-seq uterus:- placenta:- prostate:0.50 ovary:0.20 testis:0.70 heart:0.15 muscle:0.15 esophagus:- stomach:- intestine:- colon:0.27     liver/hepato:0.00        lung:0.25    bladder:- kidney:0.09 pituitary:- thyroid/parathyroid:0.30 adrenal gland:0.16 pancreas:- breast:0.15 salivary:-

Gene Information

IDs

Refseq ID NM_001005366
Gene ID 84678
Unigene ID Hs.524800
Probe set ID -
Ensembl ID ENSG00000089094
GTEx ID ENSG00000089094

Orthologous Gene

Mouse[3]  NM_001003953, NM_001005866, NM_013910
Rat [0]  

Chromosomal Region

12q24.31  [121,866,902  -  122,018,920]

Gene Family (Interpro ID)

IPR003347  Transcription factor jumonji/aspartyl beta-hydroxylase
IPR019787  Zinc finger, PHD-finger
IPR001965  Zinc finger, PHD-type

Link to Pubmed  (Pubmed ID)

10799292
12477932
14702039
15302935
15489334
15520277
16362057
16943429
17463251
17672918
17704768
17994099
19202064
19471022
20211142
20379614
20682791
21139048
21252908
21693764
22086844
22325352
22581228
22825849
23321669
23395003
24457600
24623842

Gene Ontology  (GO ID)

Biological Process

GO:0048596  embryonic camera-type eye morphogenesis
GO:0030900  forebrain development
GO:0021592  fourth ventricle development
GO:0030902  hindbrain development
GO:0016577  histone demethylation
GO:0021993  initiation of neural tube closure
GO:0021670  lateral ventricle development
GO:0030901  midbrain development
GO:0021555  midbrain-hindbrain boundary morphogenesis
GO:0043524  negative regulation of neuron apoptosis
GO:0000122  negative regulation of transcription from RNA polymerase II promoter
GO:0007283  spermatogenesis
GO:0021678  third ventricle development
GO:0006351  transcription, DNA-dependent

Cellular Component

GO:0005730  nucleolus
GO:0005634  nucleus
GO:0031519  PcG protein complex

Molecular Function

GO:0003677  DNA binding
GO:0032452  histone demethylase activity
GO:0051864  histone demethylase activity (H3-K36 specific)
GO:0016702  oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
GO:0005515  protein binding
GO:0019843  rRNA binding
GO:0008270  zinc ion binding