integrin, alpha 8

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Synonym

ITGA8, integrin, alpha 8, Integrin alpha-8 precursor

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:8.30 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:30.70 spine:- retina:- eye:11.80 artery/aorta:30 vein:- lymphnode:- peripheral blood:- spleen:37.80 thymus:- bone marrow:- adipose:- bone:- skin:9.60
GeneChip cerebrum:4.76 cerebellum:4.67 brain stem:4.55 corpus callosum/glia:4.26 pineal gland:- peripheral nerve:5.31 spine:4.61 retina:- eye:- artery/aorta:9.52 vein:9.19 lymphnode:6.50 peripheral blood:- spleen:7.76 thymus:3.95 bone marrow:4.65 adipose:5.91 bone:- skin:4.93
CAGE cerebrum:1.66 cerebellum:- brain stem:1.51 corpus callosum/glia:1.67 pineal gland:3.04 peripheral nerve:- spine:1.51 retina:- eye:- artery/aorta:6.86 vein:4.10 lymphnode:2.40 peripheral blood:- spleen:3.60 thymus:0.50 bone marrow:- adipose:2.48 bone:- skin:-
RNA-seq cerebrum:1.10 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:3.65 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:1.35 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:118.50 placenta:- prostate:157.70 ovary:- testis:8.70 heart:- muscle:40.20 esophagus:- stomach:- intestine:- colon:25.40     liver/hepato:-        lung:44    bladder:- kidney:10.40 pituitary:116 thyroid/parathyroid:- adrenal gland:- pancreas:- breast:9.30 salivary:-
GeneChip uterus:6.64 placenta:3.98 prostate:6.69 ovary:5.82 testis:4.33 heart:6.19 muscle:5.14 esophagus:5.35 stomach:7.19 intestine:5.48 colon:5.98 liver/hepato:4.67 lung:7.90 bladder:- kidney:6.18 pituitary:5.14 thyroid/parathyroid:5.65 adrenal gland:7.87 pancreas:5.12 breast:6.07 salivary:4.65
CAGE uterus:4.16 placenta:0.16 prostate:3.78 ovary:3.64 testis:2.50 heart:3.29 muscle:2.01 esophagus:3.36 stomach:- intestine:2.31 colon:2.67     liver/hepato:0.78    lung:4.14 bladder:3.87 kidney:2.66 pituitary:2.01 thyroid/parathyroid:2.28 adrenal gland:- pancreas:0 breast:2.02 salivary:1.58
RNA-seq uterus:- placenta:- prostate:2.72 ovary:1.67 testis:2.96 heart:1.47 muscle:1.34 esophagus:- stomach:- intestine:- colon:1.64     liver/hepato:0.17        lung:3.83    bladder:- kidney:1.96 pituitary:- thyroid/parathyroid:1.72 adrenal gland:4.64 pancreas:- breast:0.65 salivary:-

Gene Information

IDs

Refseq ID NM_003638
Gene ID 8516
Unigene ID Hs.171311
Probe set ID 214265_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000077943
GTEx ID ENSG00000077943

Orthologous Gene

Mouse[1]  NM_001001309
Rat [0]  

Chromosomal Region

10p13  [15,555,948  -  15,762,124]

Gene Family (Interpro ID)

IPR013517  FG-GAP
IPR013519  Integrin alpha beta-propellor

Link to Pubmed  (Pubmed ID)

7541634
7559467
7768999
9614184
10504498
11470831
11668187
12060755
12415008
12787402
15164054
15579315
15592496
15721307
16385451
18277079
19197348
19342381
19527220
19915575
20678483
20942236
21906983
23142384
23153507
24024966
24439109

Gene Ontology  (GO ID)

Biological Process

GO:0030030  cell projection organization
GO:0016337  cell-cell adhesion
GO:0007160  cell-matrix adhesion
GO:0045184  establishment of protein localization
GO:0030198  extracellular matrix organization
GO:0042472  inner ear morphogenesis
GO:0007229  integrin-mediated signaling pathway
GO:0007613  memory
GO:0001656  metanephros development
GO:0007399  nervous system development
GO:0030511  positive regulation of transforming growth factor beta receptor signaling pathway
GO:0048745  smooth muscle tissue development

Cellular Component

GO:0034678  alpha8-beta1 integrin complex
GO:0045177  apical part of cell
GO:0008305  integrin complex
GO:0005886  plasma membrane

Molecular Function

GO:0046872  metal ion binding