myosin light chain kinase 2

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Synonym

KMLC, skMLCK, MYLK2, MLCK2, myosin light chain kinase 2, skeletal muscle

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:- cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:30.70 spine:- retina:- eye:5.90 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
GeneChip nodata
CAGE cerebrum:0.06 cerebellum:- brain stem:0 corpus callosum/glia:0.13 pineal gland:0 peripheral nerve:- spine:0 retina:- eye:- artery/aorta:0.87 vein:2.59 lymphnode:0.98 peripheral blood:- spleen:0 thymus:0.28 bone marrow:- adipose:2.01 bone:- skin:-
RNA-seq cerebrum:0.12 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0.11 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:341.50 esophagus:- stomach:- intestine:- colon:8.50     liver/hepato:-        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip nodata
CAGE uterus:0.06 placenta:0 prostate:0.08 ovary:0.07 testis:0.28 heart:0.50 muscle:6.06 esophagus:2.01 stomach:- intestine:0.14 colon:0.08     liver/hepato:0    lung:0.17 bladder:0.09 kidney:0.21 pituitary:0 thyroid/parathyroid:1.71 adrenal gland:- pancreas:2.86 breast:0 salivary:1.00
RNA-seq uterus:- placenta:- prostate:0 ovary:0.00 testis:0.26 heart:0.02 muscle:7.16 esophagus:- stomach:- intestine:- colon:0.04     liver/hepato:0        lung:0    bladder:- kidney:0.09 pituitary:- thyroid/parathyroid:2.93 adrenal gland:0.05 pancreas:- breast:3.34 salivary:-

Gene Information

IDs

Refseq ID NM_033118
Gene ID 85366
Unigene ID Hs.86092
Probe set ID -
Ensembl ID ENSG00000101306
GTEx ID ENSG00000101306

Orthologous Gene

Mouse[1]  NM_001081044
Rat[1]  NM_057209

Chromosomal Region

20q11.21  [30,407,111  -  30,422,492]

Gene Family (Interpro ID)

IPR000719  Protein kinase, catalytic domain
IPR011009  Protein kinase-like domain
IPR002290  Serine/threonine-protein kinase domain
IPR017442  Serine/threonine-protein kinase-like domain
IPR001245  Tyrosine-protein kinase, catalytic domain
IPR020635  Tyrosine-protein kinase, subgroup, catalytic domain

Link to Pubmed  (Pubmed ID)

2839493
8681137
9147985
10198165
11733062
11780052
12477932
14500714
15489334
16448786
17643375
18303054
18828194
18976975
19471022
19667195
19875381
20301559
20301725
20618440
21080425
21182203
21182205
21726808
22939624
23428871
23798571
23973329

Gene Ontology  (GO ID)

Biological Process

GO:0055007  cardiac muscle cell differentiation
GO:0060048  cardiac muscle contraction
GO:0055008  cardiac muscle tissue morphogenesis
GO:0007274  neuromuscular synaptic transmission
GO:0018107  peptidyl-threonine phosphorylation
GO:0010628  positive regulation of gene expression
GO:0046777  protein amino acid autophosphorylation
GO:0032971  regulation of muscle filament sliding
GO:0014816  satellite cell differentiation
GO:0006941  striated muscle contraction

Cellular Component

GO:0005737  cytoplasm
GO:0005634  nucleus
GO:0030017  sarcomere

Molecular Function

GO:0005524  ATP binding
GO:0005516  calmodulin binding
GO:0004683  calmodulin-dependent protein kinase activity
GO:0004687  myosin light chain kinase activity
GO:0005515  protein binding