calcium/calmodulin-dependent serine protein kinase (MAGUK family)

Synonym

LIN2, CASK, Peripheral plasma membrane protein CASK, Calcium/calmodulin-dependent serine protein kinase, Lin-2 homolog, hCASK

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:30.80

cerebellum:12.60

brain stem:-

corpus callosum/glia:29.20

pineal gland:148.30

peripheral nerve:122.70

spine:-

retina:-

eye:52.90

artery/aorta:-

vein:-

lymphnode:40.40

peripheral blood:-

spleen:37.80

thymus:64.40

bone marrow:-

adipose:-

bone:12.80

skin:57.60

GeneChip

cerebrum:7.01

cerebellum:6.52

brain stem:6.88

corpus callosum/glia:7.25

pineal gland:-

peripheral nerve:6.91

spine:7.29

retina:-

eye:-

artery/aorta:7.11

vein:6.78

lymphnode:6.74

peripheral blood:-

spleen:6.80

thymus:7.29

bone marrow:5.89

adipose:6.76

bone:-

skin:6.49

CAGE

cerebrum:2.73

cerebellum:-

brain stem:3.00

corpus callosum/glia:3.42

pineal gland:2.92

peripheral nerve:-

spine:2.80

retina:-

eye:-

artery/aorta:3.07

vein:3.26

lymphnode:3.01

peripheral blood:-

spleen:2.64

thymus:3.64

bone marrow:-

adipose:2.54

bone:-

skin:-

RNA-seq

cerebrum:2.49

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:2.23

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:2.14

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:54.70

placenta:18.20

prostate:56.30

ovary:186.30

testis:8.70

heart:89.40

muscle:20.10

esophagus:-

stomach:21.20

intestine:-

colon:67.80

liver/hepato:105.60

lung:29.30

bladder:251.20

kidney:93.60

pituitary:-

thyroid/parathyroid:163.70

adrenal gland:50.80

pancreas:26.70

breast:102.20

salivary:-

GeneChip

uterus:6.96

placenta:6.09

prostate:6.85

ovary:7.23

testis:5.48

heart:6.22

muscle:6.07

esophagus:6.58

stomach:7.12

intestine:7.27

colon:7.11

liver/hepato:6.45

lung:6.85

bladder:-

kidney:6.78

pituitary:6.90

thyroid/parathyroid:6.56

adrenal gland:6.90

pancreas:6.44

breast:7.20

salivary:7.05

CAGE

uterus:2.96

placenta:1.92

prostate:2.89

ovary:2.97

testis:1.70

heart:2.44

muscle:1.72

esophagus:2.82

stomach:-

intestine:3.84

colon:3.55

liver/hepato:2.41

lung:2.83

bladder:2.65

kidney:2.58

pituitary:2.43

thyroid/parathyroid:2.32

adrenal gland:-

pancreas:2.71

breast:3.02

salivary:2.69

RNA-seq

uterus:-

placenta:-

prostate:2.40

ovary:3.27

testis:1.48

heart:1.30

muscle:1.11

esophagus:-

stomach:-

intestine:-

colon:2.35

liver/hepato:1.49

lung:2.26

bladder:-

kidney:2.53

pituitary:-

thyroid/parathyroid:2.11

adrenal gland:2.35

pancreas:-

breast:2.40

salivary:-

IDs

Refseq ID	NM_001126055
Gene ID	8573
Unigene ID	Hs.495984
Probe set ID	211208_s_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000147044
GTEx ID	ENSG00000147044

Orthologous Gene

Mouse[6]	NM_009806
Rat [0]

Chromosomal Region

Xp11.4 [41,374,187 - 41,782,716]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

IPR008144	Guanylate kinase
IPR008145	Guanylate kinase/L-type calcium channel
IPR004172	L27
IPR000719	Protein kinase, catalytic domain
IPR011009	Protein kinase-like domain
IPR002290	Serine/threonine-protein kinase domain
IPR017442	Serine/threonine-protein kinase-like domain
IPR001245	Tyrosine-protein kinase, catalytic domain
IPR020635	Tyrosine-protein kinase, subgroup, catalytic domain

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

GO:0070509	calcium ion import
GO:0007155	cell adhesion
GO:0030198	extracellular matrix organization
GO:0001953	negative regulation of cell-matrix adhesion
GO:0010839	negative regulation of keratinocyte proliferation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter

Cellular Component

GO:0015629	actin cytoskeleton
GO:0005604	basement membrane
GO:0016323	basolateral plasma membrane
GO:0005911	cell-cell junction
GO:0060170	cilium membrane
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005652	nuclear lamina
GO:0016363	nuclear matrix
GO:0005730	nucleolus
GO:0005886	plasma membrane
GO:0042734	presynaptic membrane

Molecular Function

GO:0005524	ATP binding
GO:0005516	calmodulin binding
GO:0004385	guanylate kinase activity
GO:0042043	neurexin binding
GO:0005515	protein binding
GO:0004674	protein serine/threonine kinase activity

calcium/calmodulin-dependent serine protein kinase (MAGUK family)

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function